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Old Dogs, New Research and the Secrets of Aging

nytimes.com

31–40 of 53 posts

Re: Old Dogs, New Research and the Secrets of Aging

#31
post #15

Earlier quoted context omitted.

I take anti-aging drugs for about 10 years. I heard about them at HN.

How has that worked out for you? What are you taking?

I survived about ten attempts to assassinate me. Still alive.

Quercetin and glycine. IMHO, they help to stay healthy and slow aging, but does not stop it. I also tried resveratrol and nicotinamide for a few months.

Re: Old Dogs, New Research and the Secrets of Aging

#32

The best thing I learned from this article: to calculate a dog's human age, you don't multiply their age times 7 (7x). You use the following formula: ln(x)*16+31 It makes sense, because a 1-year-old dog definitely seems much more grown up than a 7 year old kid.

Umm...doesn't the formula imply that the dog age starts at 31? That makes no sense either. My 1 year old dog is definitely not a 31 year old adult as far as behavior goes (incidentally, I am myself ~31,). I'd put 1 year approximately equivalent to a teenager, depending on the size of the breed (12 year old for larger breeds, late teens for small breeds)

Not quite. Ages are usually counted from 0. ln(0) is undefined, but after that from the first moment after birth until some time in its 52nd day, a dog's age is negative in dog-time (that's probably why it's considered important for the puppy to remain with its parents during this period; a negative-aged dog on its own is like a naked singularity). Then from day 52 to the end of its first year, the dog will age from 0 to 31.

The other end of the scale is surprising too: 200 human years is less than 116 dog years.

Re: Old Dogs, New Research and the Secrets of Aging

#33
post #6

aging (and anti-aging medication) has the potential to become the next big thing. My dog is part if the DogAgingProject and it’s really exciting to see some focus on something that impacts all of us.

I have such mixed feelings about this. It's not a great movie but this really does remind me of Elysium, in that we're truly heading for a world where those with means can live indefinitely. And those without means...

And those without means...

Will also be able to get antiaging treatments, if for no other reason that it would save a fortune in medical expenses.

Re: Old Dogs, New Research and the Secrets of Aging

#34
post #22

From my grandparent to me, there has always been German Shepherds in our family. Starting the 80's all of our dogs started dying much earlier, ~6-7 of cancer. In the early 2000's, we switched to raw diet from premium store bought kibble to raw. Sure enough, not only did their coat improve not a single cancer death under age of 13. I know it's anecdotal, but in my dog world circle and family, we've all observed simila…

Dogs evolved to eat human scraps. Raw diets may be better nutritionally than kibbles, but cooking the same food is more nutritious and much safer[1] than raw food.

After talking to board-certified vets who actually research this stuff, I feed my dog home-cooked human-grade food.

1. https://skeptvet.com/Blog/2018/02/yet-another-study-shows-th...

Re: Old Dogs, New Research and the Secrets of Aging

#35
Whenever travel to The Stars comes up on Hacker News, lots of people chime in with the impossibility of it all because of the hard limit of c, calling all such "Warp Speed" or "Hyperspace" notions handwaving fantasy.

But that overlooks age extension. Even if this Universe's rules make FTL impossible, 500 year lifespans changes it all. And that seems more likely with every passing decade.

Re: Old Dogs, New Research and the Secrets of Aging

#36

Whenever travel to The Stars comes up on Hacker News, lots of people chime in with the impossibility of it all because of the hard limit of c, calling all such "Warp Speed" or "Hyperspace" notions handwaving fantasy. But that overlooks age extension. Even if this Universe's rules make FTL impossible, 500 year lifespans changes it all. And that seems more likely with every passing decade.

> And that seems more likely with every passing decade.

How so?

Average/median life expectancy has gone up, sure. But we had 80+ y.o. and 90+ y.o. people in the Roman Empire, too.

Tell me where's the real science to suggest that we are really extending lifespans. I don't see much.

Re: Old Dogs, New Research and the Secrets of Aging

#37
post #31

Earlier quoted context omitted.

How has that worked out for you? What are you taking?

I survived about ten attempts to assassinate me. Still alive. Quercetin and glycine. IMHO, they help to stay healthy and slow aging, but does not stop it. I also tried resveratrol and nicotinamide for a few months.

Is there good evidence for quercetin alone? I recall reading a bit about quercetin with other things (I think it was a chemo med at lower dose) as a senolytic but not quercetin alone.

Re: Old Dogs, New Research and the Secrets of Aging

#38

Whenever travel to The Stars comes up on Hacker News, lots of people chime in with the impossibility of it all because of the hard limit of c, calling all such "Warp Speed" or "Hyperspace" notions handwaving fantasy. But that overlooks age extension. Even if this Universe's rules make FTL impossible, 500 year lifespans changes it all. And that seems more likely with every passing decade.

> And that seems more likely with every passing decade. How so? Average/median life expectancy has gone up, sure. But we had 80+ y.o. and 90+ y.o. people in the Roman Empire, too. Tell me where's the real science to suggest that we are really extending lifespans. I don't see much.

We aren't. Yet. Gerontology has nothing to do with past public health improvements. Just like horses didn't evolve over generations into the automobile, anti-aging technology breakthroughs will be new tech and irregular. Such as telomere modification. And probably kill some people at first. "You can tell the pioneers by the arrows in their backs."

Re: Old Dogs, New Research and the Secrets of Aging

#39
Semi-related: "Why old dogs are the best dogs" https://theweek.com/articles/511596/why-old-dogs-are-best-do...

> Puppies are incomparably cute and incomparably entertaining, and, best of all, they smell exactly like puppies. At middle age, a dog has settled into the knuckleheaded matrix of behavior we find so appealing — his unquestioning loyalty, his irrepressible willingness to please, his infectious happiness. But it is not until a dog gets old that his most important virtues ripen and coalesce. Old dogs can be cloudy-eyed and grouchy, gray of muzzle, graceless of gait, odd of habit, hard of hearing, pimply, wheezy, lazy, and lumpy. But to anyone who has ever known an old dog, these flaws are of little consequence. Old dogs are vulnerable. They show exorbitant gratitude and limitless trust. They are without artifice. They are funny in new and unexpected ways. But, above all, they seem at peace.

Re: Old Dogs, New Research and the Secrets of Aging

#40
post #5
post #2

I've noticed more health and aging related articles on this site. I wonder if its a sign the HN community is getting older. :)

The site is almost 15 years old so it’s possible. People become a little more self-aware as they get older. First you know someone famous that died young from a horrible disease. Next you personally know someone who died from a disease. Then you get older and wonder if the “1 in 3 people” might be you.

Outliving your parents is very perspective changing.

Knowing people younger than you who die of old man's diseases.

Your doctor is younger than you are.

The President is younger than you are.

Your longtime friends look old.

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