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Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

pubs.acs.org

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Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#31

Earlier quoted context omitted.

They didn’t research that question, and I don’t see any reason why it would be implied from their findings.

In the Abstract section it is shown that 20 micrograms does not increase BDNF levels after 2 hours, as opposed to 5 micrograms. It is shown however that it increases after 4 hours. That was a little confusing

That’s true. 20 ug is still quite a low dose though. People taking LSD for recreational purposes will generally take somewhere from 100-500 ug. A “hit” is generally 100-200 ug.

I don’t think their research allows us to infer anything about BDNF response at these levels, which is what I (possibly mistakenly) assumed you were asking about.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#32
post #2

Anyone with first hand experience of LSD ?

Please, you're on a discussion site where the main demographic is actively microdosing to improve their productivity at startups inbetween two editions of Burning Man. You'd be hardpressed to find someone without a first-hand experience of acid. But yeah, you pretty much tend to remember everything that happens to you during a trip, even years afterwards, which naively makes me believe your brain and memories become…

Utterly pretentious, dweeby reason to take acid

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#33
post #16
post #15

Earlier quoted context omitted.

Yes, I have tried it. Only micro-doses. It takes about an hour to kick in, and for me, lasts about 6-8 hours. It feels like it silences any inner critic in me, so I am a lot more free thinking. I have used it several times to overcome getting stuck on a programming problem, but I have to write the solution down because I usually get too distracted while using it to be able to focus enough to implement. The problems i…

Sounds like you had a bit more than a micro-dose, but interesting way of applying these doses!

6-8 hours is not microdose territory. that's a half dose.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#34

Earlier quoted context omitted.

They didn’t research that question, and I don’t see any reason why it would be implied from their findings.

In the Abstract section it is shown that 20 micrograms does not increase BDNF levels after 2 hours, as opposed to 5 micrograms. It is shown however that it increases after 4 hours. That was a little confusing

And 10 micrograms does not increase it. So 5 and 20 does, but 10 does not?

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#36
post #2

Anyone with first hand experience of LSD ?

I used it at a birthday party a few years ago. My main takeaways were twofold:

First, it made me understand the concept of good and bad "vibes" w.r.t. to drug use. It was clear that the experience of taking LSD recreationally in a group of people was a much a social experience as a chemical one. Keeping the "vibe" positive, by playing the right kind of music, staying chill, and saying and doing the right things, was important not to break the spell. Unfortunately, as somebody who suffers from social anxiety, this awareness made things quite stressful for me at times, as I felt I had to constantly maintain some level of self-regulation, which was not made easier by how intoxicated I was. I have the same problem when smoking weed in company.

Second, while I hoped for the kind of psychological breakthroughs and revelations that some people describe having using LSD, I didn't experience them. I never felt connected to the universe or some greater purpose. I certainly had periods of intense introspection, but they didn't reveal anything to my about my character I wasn't already aware of. I think part of that was that I was already in my mid-thirties at the time, and had done plenty of introspection over the years. I already had a good understanding of my own character — my strengths, weaknesses, hopes, fears and regrets — and I suspect anybody with a similar disposition won't have any breakthroughs using LSD.

Ultimately, I didn't regret trying LSD, but it didn't leave me with any desire to try it again. Despite its reputation, it just seemed like another drug to me. Stronger in its effect than most, but I never felt like a child of the universe, I just felt high.

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#37
post #16

Earlier quoted context omitted.

Sounds like you had a bit more than a micro-dose, but interesting way of applying these doses!

6-8 hours is not microdose territory. that's a half dose.

Ah thank you! I am very much experimenting at the moment, and don't really have anyone more experienced to talk to, so I wasn't sure what "high" / "medium " / "micro" was ....

Re: Low Doses of LSD Acutely Increase BDNF Blood Plasma Levels in Healthy Volunteers

#40

There must be some axiom here that mention of LSD in any story, however scientific in nature, turns into trip reports.

Why wouldn't it? It's the #1 thing people associate with it as a personal experience...
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