I like Serum a lot, but it has the same set of issues that make all of these digital synths limited as performance instruments compared to, say, a piano.
The issue starts with the low resolution of MIDI. Most instruments implement only velocity connected to keys, with max 128 layers of resolution.
A real piano has near infinite resolution on velocity alone.
This exacerbates the issue that digital synths are generally deterministic, meaning for the same input they produce the same output.
Because the resolution of the controller is so low, attempts to introduce variety rely on randomness. In an acoustic instrument the same sound cant ever be produced twice. But this is a result of a complex, chaotic system, not randomness.
A major factor in the inherently chaotic sound is that each note is exciting the same physical object, even a note played with the same velocity (like a disklavier piano system could) will sound different every time based on the state of the whole large object. As notes are added to a chord or arpeggio, they are not just superimposed over each other, instead they each contribute their energy to the whole object.
The use of mod wheels definitely helps with expressiveness in the hands of a good player.
But my sense is that even “players” are forgoing using these instruments as performance tools, and instead loop the sections, and piece through the whole song, listening carefully, modifying the midi data directly based on what they a hearing.
This has definitely resulted in some very imaginative and striking work, but, to my ear anyway, it has a very different feel as a mode of artistic expression. It’s more “cerebral” in some way.