I’m working in proximate space. Every research paper about nutrition in general and gut bacteria specifically should be assumed shit science.
I see what you did there.
Secret to longevity may lie in the microbiome and the gut
31–40 of 47 posts
Re: Secret to longevity may lie in the microbiome and the gut
#32Earlier quoted context omitted.
Except that they get prescribed a lot, almost as an insurance.
And in some countries, they give antibiotics for viral infections because patients just want them! Got the common cold? Here's some Amoxicillin!
Worse, in China they are sold OTC and are as popular as you suggest (aside from being the thing that is prescribed on nearly every doctors visit to a health center). Even though anti-viral medicines (for what little good those do...) are also available OTC...
Re: Secret to longevity may lie in the microbiome and the gut
#33In a few years we might look back at this period and think: oh, it was at the time when we thought gut bacteria was the solution to every health problem known to mankind. Remember when it was vitamin D?
When was vitamin D discredited?
Re: Secret to longevity may lie in the microbiome and the gut
#34I’m working in proximate space. Every research paper about nutrition in general and gut bacteria specifically should be assumed shit science.
Interested in learning more if you have time to expand. Cheers
Sure. I see 3 recurring issues with "nutritional research" I'm exposed to:
1. Wayyyyy too much industry involvement, much of it not properly disclosed (OP here is a classical and representative example).
2. Lots of research from relatively small and "less known" institutes, done by researchers with hard to verify credentials.
3. Low scientific standards. That'd include:
- Refusal to share data
- Refusal to share data analysis methods
- Not keeping the basics of a double-blinded test
- No reproduction, and not even the possibility of independent reproducibility, as the methods are described so vaguely.
Re: Secret to longevity may lie in the microbiome and the gut
#35I think there's been very little evolutionary pressure to increase lifespan in creatures like fruit flies since despite their short lifespan few of them die from age related causes. I would assume it's pretty easy to increase the lifetime of short-lived creatures in a protected environment, and pretty unlikely that the methods which accomplish this would also extend the lives of long-lived creatures.
What do fruit flies usually die from?
Looks silly at first glance, but I think it is a very interesting question. Asking Google I found a lot of "they die", but no good research about the cause (admittedly, I only spend a few minutes). Only one other - still open - question on Quora: https://www.quora.com/Has-anyone-tracked-the-cause-of-death-... -- The only answer says it has not been studied thoroughly, but it is from someone whose professional and job title ("Biomedical gerontologist, Chief Science Officer of SENS Foundation") sound like he would/should know.
I think it is implied that the cause of death is ageing? What else would it be (lab fruit flies don't have predators)?
I found a hint here: http://genomics.senescence.info/species/entry.php?species=Dr...
> Little is known about causes of death in old fruit flies but cardiac ageing has been reported [0981].
That sentence indicates that the question is not very well researched?
If that is true I find it amazing that there are ageing studies, shouldn't their own cause of death be well-known?
To @gweinberg, if you are reading this, what do you base this on? You wrote
> few of them die from age related causes
Re: Secret to longevity may lie in the microbiome and the gut
#36I'm a believer in the importance of the microbiome, but this study seems fishy: * the authors have already started a company and pursued a patent on their ayurvedic-derived formulation * the figure 1(a) in their paper ( https://www.nature.com/articles/s41598-018-25382-z#Fig1 ) doesn't show a big difference from plain probiotics to their formulation, but does show some oddities in the Y-axis where, for the control gro…
I would´t trust my nose to detect fishiness. These expermients simply need to be reproduced independently to be verified. Until then, it's anti-scientific to assume anything about fishiness. The reported facts do NOT PROVE that the results were forged.
Re: Secret to longevity may lie in the microbiome and the gut
#37Earlier quoted context omitted.
Interested in learning more if you have time to expand. Cheers
Sure. I see 3 recurring issues with "nutritional research" I'm exposed to: 1. Wayyyyy too much industry involvement, much of it not properly disclosed (OP here is a classical and representative example). 2. Lots of research from relatively small and "less known" institutes, done by researchers with hard to verify credentials. 3. Low scientific standards. That'd include: - Refusal to share data - Refusal to share data…
You identified the problem. What’s the solution?
Re: Secret to longevity may lie in the microbiome and the gut
#38Earlier quoted context omitted.
Sure. I see 3 recurring issues with "nutritional research" I'm exposed to: 1. Wayyyyy too much industry involvement, much of it not properly disclosed (OP here is a classical and representative example). 2. Lots of research from relatively small and "less known" institutes, done by researchers with hard to verify credentials. 3. Low scientific standards. That'd include: - Refusal to share data - Refusal to share data…
You identified the problem. What’s the solution?
The solution is identification of bad methods and subsequent ignorance.
If only we had a metric for credible science that takes authors, institutions, publisher and funding sources into account....
Re: Secret to longevity may lie in the microbiome and the gut
#39I'm a believer in the importance of the microbiome, but this study seems fishy: * the authors have already started a company and pursued a patent on their ayurvedic-derived formulation * the figure 1(a) in their paper ( https://www.nature.com/articles/s41598-018-25382-z#Fig1 ) doesn't show a big difference from plain probiotics to their formulation, but does show some oddities in the Y-axis where, for the control gro…
I would´t trust my nose to detect fishiness. These expermients simply need to be reproduced independently to be verified. Until then, it's anti-scientific to assume anything about fishiness. The reported facts do NOT PROVE that the results were forged.
Nobody is claiming that it does. They are indicating possible economic investment in the results and some questionable statistics. It is perfectly scientific to take these pieces of evidence and adjust the possibility of this study being fishy upwards.
Re: Secret to longevity may lie in the microbiome and the gut
#40In a few years we might look back at this period and think: oh, it was at the time when we thought gut bacteria was the solution to every health problem known to mankind. Remember when it was vitamin D?
That's also how chiropractics started.