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Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

nature.com

31–40 of 80 posts

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#31

Earlier quoted context omitted.

Where did you get it, and how did you administer it?

Ketamine is available both as a veterinary medicine and is used as an emergency anesthetic (usually for setting broken bones) because it doesn't require an anesthesiologist. Where I obtained it-- Darknet. I used veterinary needles to do an IM injection. There are also analogues that can be snorted.

[deleted]

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#32

i did some work around ketamine a few years ago and many physicians i spoke with said it was incredibly helpful for their patients. however there are many others who have said it doesnt work for many of their patients. there are many studies that suggest it works and a lot of other unpublished data suggesting maybe it isnt as great the mechanism of action is also poorly understood, and while this article may certainl…

The dirty argument is not a great one, though, because most illnesses (especially depression) cause changes to a number of networks, and not just one particular receptor subtype or subunit of that receptor subtype. I agree that more mechanistic studies (and more clinical studies) need to be done anyways, but having multiple action sites isn't necessarily a bad thing. As far as the "jolt" and continued therapy with CB…

I agree, I meant to say that the "dirty" drug is more effective. If we just isolate one mechanism of action (like NMDA receptor antagonism) and make a specific drug for that, you lose all the other off target effects that could be beneficial

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#33

I have been looking into Ketamine as there is a clinic which administers Ketamine therapy in my area. The disappointing thing is that it looks like the effects are short lived, and one may need "booster" treatments every 4 weeks, at $400 a shot, for years and possibly forever. I hope with this understanding, we come up with something more permanent.

It's not that expensive on darknet markets.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#34

Earlier quoted context omitted.

Where did you get it, and how did you administer it?

Ketamine is available both as a veterinary medicine and is used as an emergency anesthetic (usually for setting broken bones) because it doesn't require an anesthesiologist. Where I obtained it-- Darknet. I used veterinary needles to do an IM injection. There are also analogues that can be snorted.

How is the darknet these days? I used SR when it was around. Is it still that easy?

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#35

I have been looking into Ketamine as there is a clinic which administers Ketamine therapy in my area. The disappointing thing is that it looks like the effects are short lived, and one may need "booster" treatments every 4 weeks, at $400 a shot, for years and possibly forever. I hope with this understanding, we come up with something more permanent.

It's not that expensive on darknet markets.

If I was going to use ketamine, I'd prefer to get it from a reputable source.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#36

I have been looking into Ketamine as there is a clinic which administers Ketamine therapy in my area. The disappointing thing is that it looks like the effects are short lived, and one may need "booster" treatments every 4 weeks, at $400 a shot, for years and possibly forever. I hope with this understanding, we come up with something more permanent.

$400/month seems a very cheap price for getting your life back.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#37

Isn't regular Ketamine use especially bad for the bladder? I recall reading multiple anecdotes from the Erowid ketamine vaults where people lost their bladders due to recreational Ketamine use.

It's a huge problem for recreational use. Some individuals have trouble with it even with prescription ketamine, but it's not nearly as common. Last time I asked him, my doctor hasn't had any patients who were forced to discontinue treatment because of it. n=1, but I've been receiving ketamine therapy for about 6 years and have not developed ketamine cystitis.

Are recreational doses significantly higher than prescription doses? Why the difference?

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#38
post #37

Earlier quoted context omitted.

It's a huge problem for recreational use. Some individuals have trouble with it even with prescription ketamine, but it's not nearly as common. Last time I asked him, my doctor hasn't had any patients who were forced to discontinue treatment because of it. n=1, but I've been receiving ketamine therapy for about 6 years and have not developed ketamine cystitis.

Are recreational doses significantly higher than prescription doses? Why the difference?

[deleted]

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#39

Earlier quoted context omitted.

Ketamine is available both as a veterinary medicine and is used as an emergency anesthetic (usually for setting broken bones) because it doesn't require an anesthesiologist. Where I obtained it-- Darknet. I used veterinary needles to do an IM injection. There are also analogues that can be snorted.

How is the darknet these days? I used SR when it was around. Is it still that easy?

I wouldn't recommend it at this moment. The powers that be did a pretty good job of knocking a lot of vendors offline-- then the runup in bitcoin made exit scams attractive while simultaneously making it cost a fortune to tumble/transfer.

Re: Ketamine blocks bursting in the lateral habenula to rapidly relieve depression

#40

I know it's anecdotal, but I've been receiving ketamine at a local clinic for a few years for chronic depression and a spinal injury. It has proven too be the most effective treatment I've had for treating depression. As another poster said, it is short lived (around two months) But the release from depression, and back pain is life changing for me. To go with the article, it is incredibly fast acting. Like same day…

Does your insurance cover it?
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