I read the paper, I saw the plots accompanying the paper, and I tried following the rabbit hole in search of some raw data that I can get my hands on, just to see if I can. Perhaps the data is the result of the experiments that have been paid for by a third party, fine, but please mention that! People might be willing to pay for it, for example, me! What's wrong with "Here's the raw data, here's how we measured it, H…
Ibuprofen alters human testicular physiology including testosterone production
31–40 of 67 posts
Re: Ibuprofen alters human testicular physiology including testosterone production
#32I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
Are there any good numbers on the fertility among people who actually WANT to conceive, rather than the raw total population rates (which is affected by people who don't want kids - prevented through birth control and abortions)
"One 2012 report, which presented the results of the study of over 26,000 French men, showed that the sperm count had fallen by a third between 1989 and 2005. A 2007 report in the UK presented the results of a study done on one city in the country. It showed that sperm counts had declined by over 29 percent between 1989 and 2002. And more recently, in the summer of 2017, a study by scientists at the Hebrew University of Jerusalem analyzed data from over 43,000 North American, European, Australian, and New Zealand men concluded that the average sperm count had fallen by almost 60 percent in the past 40 years. "
From an article at https://www.inquisitr.com/4757173/the-human-race-could-be-in... dated just a few days ago
Re: Ibuprofen alters human testicular physiology including testosterone production
#33I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
I doubt there is one smoking gun. It's a basket of causes. Too much exposure to weird chemicals, ibuprofen, not enough zinc, obesity, lack of exercise, etc are all causes.
Re: Ibuprofen alters human testicular physiology including testosterone production
#34While the results do matter, this is probably being blown out of proportion > One group of subjects received ibuprofen, 2 × 600 mg/d, (Ibumetin; Nycomed Denmark Aps) for a period of 6 wk Yeah, that's a lot of Ibuprofen for a long time
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
And I believe the max dose is even higher - 3200mg per day (800mg 4 times per day).
Re: Ibuprofen alters human testicular physiology including testosterone production
#35Earlier quoted context omitted.
Nope, that is literally the dosage mentioned in leaflet inside my box of pills: 2x200mg, up to 3 times a day, do not exceed 6 weeks.
And I believe the max dose is even higher - 3200mg per day (800mg 4 times per day).
Yep. a good friend is a doctor who does triage in an ER (amongst other things) - he said 'We start at 1500mg doses'.
Re: Ibuprofen alters human testicular physiology including testosterone production
#36Earlier quoted context omitted.
As far as I know this is slowly changing. According to scientists I've met (life science fields) there is an ongoing trend towards demanding raw data and even the code used to analyze it. Not every journal everywhere yet of course, but the consensus seemed to be that in 5 to 10 years it would become the new norm. Which might cause quite the disruption. Having seen quite the amounts of code written by PHD students I'm…
This is exactly the motivation behind the Loom file format[0] being developed and used in the molecular neurobiology-group I work for[1]. It is an HDF5-based file format for 'omics data, to deal with the ever-growing size of the data sets. I specifically work on the Loom Viewer[1], a SPA that we're trying to design in such a way that it will be really easy and cheap for research groups to host and share these loom fi…
This is a significant amount of effort, and has some very good touches. Especially the Loom-Viewer, I really liked the ease with which one's workflow can integrate into the data analysis.
Re: Ibuprofen alters human testicular physiology including testosterone production
#37I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
My money would be on increasing levels of education and healthcare instead of fire retardant chemicals and ibuprofen.
How exactly would education affect the testicles?
Re: Ibuprofen alters human testicular physiology including testosterone production
#38I've been paying attention to the lowering fertility rate across the world. My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disruptor. It didn't totally fit though so I felt like there was something else that was a major contributor. Ibuprofen being a cause of lower sperm counts could be the missing piece of the puzzle. It's also a big deal becau…
My instinct, until now, was that it was because of fire retardant chemicals found in furniture that act as an endocrine disrupto
What are your thoughts on synthetic hormones, e.g. used in farming or in contraception? Those enter the water supply and are not broken down.
Re: Ibuprofen alters human testicular physiology including testosterone production
#39Is this a permanent effect, or does T production return to normal after stopping the drug?
> For the small group of young study participants who used ibuprofen for only a short time, “it is sure that these effects are reversible,” Jégou said. However, it’s unknown whether the health effects of long-term ibuprofen use are reversible, he said.
http://wgntv.com/2018/01/08/ibuprofen-linked-to-male-inferti...
Re: Ibuprofen alters human testicular physiology including testosterone production
#40Is this a permanent effect, or does T production return to normal after stopping the drug?
> For the small group of young study participants who used ibuprofen for only a short time, “it is sure that these effects are reversible,” Jégou said. However, it’s unknown whether the health effects of long-term ibuprofen use are reversible, he said. http://wgntv.com/2018/01/08/ibuprofen-linked-to-male-inferti...
> For the small group of young study participants who used ibuprofen for only a short time, “it is sure that these effects are reversible,” Jégou said.
That could be true, but of course, there's some self-interest in that statement. Bringing long-term harm to your study participants is not exactly a good move for a medical researcher.