Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

Post reply on HN
Print view View original

291–300 of 553 posts

Re: GLP-1 drugs: An economic disruptor? (2024)

#291

Post by Henchman21 »

no_wizard wrote: post #276
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I’m not going to lie all this sounds like heaven to me. I absolutely hate the way my appetite works. I have a genuine dysfunction with food. It goes back as far as I can remember. My cravings never stop, even after being satiated. It’s an endless cycle of weight gain then loss then gain as my willpower fluctuates for a variety of reasons. My insurance only recently started to cover these weight loss drugs, and I have…

I'm a few months into this drug as well, and I have to say, it doesn't offer control. What it offers is a lack of cravings & appetite. That is different, remarkably so.

Control would mean I might still feel hungry. Ever. Or that I could decide to eat heavily at one meal, but I don't and as long as I take the drugs, I won't. That doesn't feel like control, it feels like I've had something removed. I guess it's a matter of perspective?

I don't know if its a common sentiment but this drug treatment is the hardest thing I've ever done for my health. I'm not sure I'll be able to continue though. It's like I've robbed myself of the one joy I had left and now I have none. Tread carefully.

Re: GLP-1 drugs: An economic disruptor? (2024)

#292

Post by aussieguy1234 »

For years, I had the opposite problem most have with their weight. My main problem was gaining it. Food was not enough - I will loose weight relying on food alone.

It seems that with food, I often don't like the taste or texture, or the sensation associated with eating. I also tend to feel full relatively quickly.

My solution was to make a shake - in this shake, I put a large amount of olive oil, mixed in with other ingredients which cancelled out the taste. Easy to consume over the day.

Over several years of having the shake, I got to a weight I'm happy with. I'm now in total control and can regulate my weight simply by adding or removing the olive oil in my shake. Over the past year I've started weight training 5 days a week and adding protein to the shake with good results.

When I go on holidays and don't have access to my blender, I reliably loose a bit of weight - probably the opposite problem most have when they go on holidays.

I'm also non drinker. Never really got on board with alcohol, didn't like the sensations of the effects.

I still eat normal meals much the same as before, just a smaller serving than what most others have.

Re: GLP-1 drugs: An economic disruptor? (2024)

#293

Post by abirch »

maleldil wrote: post #289
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

gastroparesis is a real side effect two, it’s where the food in your digestive tract stops moving. As in 30% of food is present after 4 hours

The rate is over 1% which isn’t a lot nor is it nothing https://jamanetwork.com/journals/jama/fullarticle/2810542

Re: GLP-1 drugs: An economic disruptor? (2024)

#294

Post by okdood64 »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

How long before it started taking effect when you started?

Re: GLP-1 drugs: An economic disruptor? (2024)

#295

Post by hownottowrite »

When I had my first real programming gig in the early 90s, I worked 14+ hours a day and ate fast food exclusively (often in very large quantities). My weight ballooned to nearly 400 pounds.

Then I got sick…

I couldn’t eat anything with fat. Just the thought of it made me physically ill. I ended up dropping half my body weight in 18 months.

What I learned is that it is possible to break your body in many ways.

Re: GLP-1 drugs: An economic disruptor? (2024)

#296

Post by gibspaulding »

Earw0rm wrote: post #88

The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…

> if there were a GLP1 for procrastination

Adderall?

Re: GLP-1 drugs: An economic disruptor? (2024)

#297

Post by taurath »

maleldil wrote: post #289
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

I tried, I got some results but it meant that my entire body’s digestive system felt like it stopped working. Constipation, nausea at the drop of a hat, finding I’d have to take a fast acting prescription anti nausea multiple times a day. I’m not that overweight, and I felt like my body was getting far less healthy and like I was starving myself. This is on the lowest starter dose, too! It just… yeah, it works as I’d expect an extreme appetite suppressant would.

Re: GLP-1 drugs: An economic disruptor? (2024)

#298

Post by Etheryte »

crazygringo wrote: post #229
submeta wrote: post #118

Big food corporations profit from ultra-processed foods that manipulate our natural systems. They design products that override satiety signals using calculated combinations of sugar, fat and salt to activate brain dopamine pathways. Their priority is profit growth, not consumer health. The consequences are significant health issues like obesity, diabetes and cardiovascular diseases. Healthcare systems struggle with…

> Big food corporations profit from ultra-processed foods that manipulate our natural systems. I've just never bought this. Does grandma manipulate you when she adds sugar to her cherry pie? Does she manipulate you when she adds salt to her mashed potatoes? Foods -- "ultra-processed" or not -- don't "manipulate" you. They literally just either taste better or taste worse. Grandma, and her grandma before her, used sug…

Many foods and beverages include ingredients whose sole purpose is to hide how sweet it is because otherwise it would be unbearable in your mouth. Gives you a stronger high once it reaches your stomach though.

Re: GLP-1 drugs: An economic disruptor? (2024)

#299

Post by lesinski »

Much as I have read research and heard stories of the knock-on health improvement effects of GLP-1s... Expect a lot of that economic value to be captured by pharmaceutical companies charging for them. And insurance companies charging higher premiums, because they're paying for everyone to be on them.

Re: GLP-1 drugs: An economic disruptor? (2024)

#300

Post by hombre_fatal »

gibspaulding wrote: post #296
Earw0rm wrote: post #88

The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…

> if there were a GLP1 for procrastination Adderall?

Amphetamine for procrastination already has an analogy for weight loss: amphetamine.

The analogy for a GLP-1 agonist for procrastination would be something safer yet possibly more effective.

Post reply on HN