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FDA Approves First Oral Treatment for Postpartum Depression

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Re: FDA Approves First Oral Treatment for Postpartum Depression

#291

Post by pertymcpert »

agensaequivocum wrote: post #104
speff wrote: post #33

Earlier quoted context omitted.

My wife is scared shitless of postpartum depression. People don't think of it as a problem because it's a "woman issue" and not a big deal. Coupled with the medical profession being notorious for discounting black womens' issues, I don't blame her for being scared. We'll be first in line for getting the pill if she needs it.

My wife an I are currently expecting baby #5. She had a only mild amount of PPD with 2. We foresee no need of this drug with this one nor any of our future babies.

Ok?

Re: FDA Approves First Oral Treatment for Postpartum Depression

#292

Post by pertymcpert »

techie128 wrote: post #105

This is a uniquely American problem and an American solution. American healthcare and society fails new mothers. Others have done a great job of pointing out the physical and emotional distress a new mother goes through. However, I'd like to point out the social aspect. New mothers in America are not supported by paid family leave. Vast majority of women are required to go back to work in about 2 weeks after birth. F…

Uniquely American problem. Are you actually serious?

Re: FDA Approves First Oral Treatment for Postpartum Depression

#293

Post by habinero »

NoZebra120vClip wrote: post #274
habinero wrote: post #267

Earlier quoted context omitted.

The suicide warning for AD is misleading. They don't _cause_ suicidal thoughts, but they can give you energy and the ability to function before they start lifting mood. So if you're already suicidal, you can regain the ability to act on it before you get relief

That's not what the label warnings say. You're specifically contradicting the label's clear language, and you're saying that the FDA and the drug manufacturer are not telling us the truth when they put that label on a drug. QED. Furthermore, subjects with suicidal ideations or attempts are disqualified from clinical trials. In practice, this also means that any subject with depression is disqualified and shall not pa…

I'm literally telling you word for word what my doctor told me, my guy.

Also, this rant is hilariously incorrect. You...do know that manufacturers continue to collect reports on side effects outside of clinical trials, right?

Re: FDA Approves First Oral Treatment for Postpartum Depression

#294

Post by habinero »

NoZebra120vClip wrote: post #276
habinero wrote: post #265

Earlier quoted context omitted.

It says nothing. They don't "scramble" your brain, or artificially make you happy, or any of the other ignorant things people have said. You are exactly the same person on AD as you are off of them. This is like pretending that anyone who gets antibiotics is weak and if you just exercise, you can beat infected wounds. Before antibiotics, people just died from wounds. Before AD, people spent their whole lives trapped…

> You are exactly the same person on AD as you are off of them. Psychotropic pharmaceutical drugs are mind-altering substances. They place people in an "altered state of consciousness". Does this sound familiar. When my cousin was allegedly afflicted by "chronic major depression", and he was prescribed Prozac, his mother commented "it's like I have my Joey back!" because his mood had lifted and he was acting very dif…

I'm sorry, but your cousin's mom's goofy nickname for them is not a relevant anecdote.

I have been on several and I'm speaking from experience. They do not make you happy. They do not induce euphoria. What they do is relieve depression. Instead of being nonfunctional and crippled, you get some energy and mood back. Ideally, enough to let you work on other things and help you get back to stable.

Plenty of people only need them for a limited time, and that's just fine.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#295

Post by habinero »

nemo44x wrote: post #285
habinero wrote: post #265

Earlier quoted context omitted.

It says nothing. They don't "scramble" your brain, or artificially make you happy, or any of the other ignorant things people have said. You are exactly the same person on AD as you are off of them. This is like pretending that anyone who gets antibiotics is weak and if you just exercise, you can beat infected wounds. Before antibiotics, people just died from wounds. Before AD, people spent their whole lives trapped…

I don’t think it’s anything line antibiotics. I don’t judge people for taking brain scramblers but I think it’s obvious they are vastly over prescribed. 20% of women are on some form of them. There’s no way that’s natural. There must be a reason you don’t see the mass adoption of these kinds of drugs in most other countries. It’s also created a culture of using a pill to solve a problem and yes in some extreme cases…

Why would you consider that not to be normal? Humans have plenty of inherent physical flaws - we have terrible backs and knees, for example. Also, plenty of other countries have similar adoption of ADs.

There was no magic beforetime when we were all happy peasants or hunter-gatherers, singing in the countryside. Humans have always lived with pain and depression and suffering, and to pretend there's any moral good to that is ridiculous, no more than there's any moral good to dying from an infection. Dying from infected wounds is "normal". Being permanently crippled from breaking a bone is 'normal".

People are so weird about things that actually help others.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#296

Post by habinero »

pazimzadeh wrote: post #275
habinero wrote: post #201

Earlier quoted context omitted.

Because the old world had plagues (diseases that spread fast and kill) and the new world did not. Plagues and pandemics are zoonotic, and the new world just didn't have any domesticable animals except llamas.

> the new world just didn't have any domesticable animals except llamas Turkeys, llamas, ducks, mink, ostrich, etc.. https://en.wikipedia.org/wiki/List_of_domesticated_animals Anyway it sounds like you're referring to Francis Galton's old take on the topic which doesn't really hold up in many ways https://galton.org/essays/1860-1869/galton-1865-domesticatio... You haven't convinced me that there were no domesticable…

The proof that there were no domesticable animals in the new world is that...no animals besides the llama [0] were domesticated. People lived here for tens of thousands of years. If something could have been domesticated, it would have, because that's what humans do.

And yes, the black plague is zoonotic, as I said. And yes, cities do contribute, because packing a lot of people together give plagues fuel. Plagues are almost always zoonotic, because any disease that kills all its hosts also dies. Plagues usually have a reservoir in animals, mutates to jump to humans and kills them by accident, really.

[0] And guinea pigs, I guess, but you can't build an empire on overgrown squeaky toys.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#297

Post by DontchaKnowit »

flangola7 wrote: post #209
zpeti wrote: post #165

Earlier quoted context omitted.

It’s very easy to explain. By going straight to medication you are treating the symptom not the cause. And you don’t even know if it works. SSRIs don’t work for many people and we only found out 2-3 years ago. Opioids were prescribed to half of America for back pain. That gives scope for healthy scepticisms at least. Just because you might have some anecdotal evidence of some chemicals working, doesn’t mean it works…

While I agree there are often additional deeper causes, picking up a prescription will begin faster than waiting for capitalism to be done away with.

Capitalism isnt depressing anyone. Jealousy? Thatll do it

Re: FDA Approves First Oral Treatment for Postpartum Depression

#298

Post by kozzz »

Traubenfuchs wrote: post #162

Does a positive allosteric modulator of the GABAa receptor cause addiction the same way any old GABA agonist does? I love GABA agonists from benzos, benzo likes to phenibut and really wonder how it feels. If it feels the same way, then it feels like being wrapped in comfortable cotton, with all worries gone -heaven on earth. Hence the extreme addiction risk.

The addiction potential and the associated risks vary greatly from benzos to phenibut. Benzo withdrawal can kill you, pregabalin or phenibut withdrawal will cause only moderate discomfort.

Re: FDA Approves First Oral Treatment for Postpartum Depression

#299

Post by vGPU »

psychphysic wrote: post #206
xyzzy_plugh wrote: post #142

Since every top level comment here is a borderline tire fire, let me be the first to say: This is great news. We need better treatments for PPD, which is real and very serious that can cause long term lasting effects in serious cases without treatment, and can sadly even be fatal. Quality of life has risen steeply over the past several decades but mothers still walk an unpaved road. It's deeply worrying the lack of s…

> We need better treatments for PPD It was compared to placebo. People are rightly highly suspicious of Big Pharma. I like the idea of a novel class but I won't pay attention to this new, expensive drug until it proves significant efficacy over older cheaper drugs (like Alprazolam and Zolpidem/Zopiclone). Technically it's a Z-drug (like Zolpidem/Ambien) which are non-benzodiazapine positive allosteric modulators of G…

It’s supposed to be an oral version of Allopregnanolone. I’d definitely be a little bit more comfortable with it than with zolpiderm, which we tried to transition everyone off of if possible.
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