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First Human Embryos Edited in U.S

technologyreview.com

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Re: First Human Embryos Edited in U.S

#291
I'm eager to see the long-term results of the gene editing procedures.

>The earlier Chinese publications, although limited in scope, found CRISPR caused editing errors and that the desired DNA changes were taken up not by all the cells of an embryo, only some.

Instability is an inherent property of genes.

Re: First Human Embryos Edited in U.S

#292

Earlier quoted context omitted.

Our genetic homogeneity implies that anatomically modern humans arose relatively recently (perhaps 200,000 years ago) and that our population size was quite small at one time (perhaps 10,000 breeding individuals). -Another strongly supported hypothesis is that there was an near-extinction event that wiped out all but a pocket of human settlements from which we descended. - The diversity in other species that are abou…

That sounds really interesting, does this hypothesis have a name so I can read up on it a bit more?

As for what might explain the near-extinction humanity apparently once experienced, perhaps another kind of catastrophe, such as disease, hit the species. It may also be possible that such a disaster never happened in the first place — genetic research suggests modern humans descend from a single population of a few thousand survivors of a calamity, but another possible explanation is that modern humans descend from a few groups that left Africa at different times.

-It's unlikely that the Toba catastrophe was the root cause of the bottleneck as reasoned in this investigation:

https://www.livescience.com/29130-toba-supervolcano-effects....

- I wonder if the hypothesis of leaving Africa in small groups could be effectively tested.

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