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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#281

Post by creer »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Thanks for the report! Aside from the loss of interest in food, what other side effects have you noticed or not noticed? (other N=1 reports welcome!)

Re: GLP-1 drugs: An economic disruptor? (2024)

#282

Post by walleeee »

crazygringo wrote: post #229
submeta wrote: post #118

Big food corporations profit from ultra-processed foods that manipulate our natural systems. They design products that override satiety signals using calculated combinations of sugar, fat and salt to activate brain dopamine pathways. Their priority is profit growth, not consumer health. The consequences are significant health issues like obesity, diabetes and cardiovascular diseases. Healthcare systems struggle with…

> Big food corporations profit from ultra-processed foods that manipulate our natural systems. I've just never bought this. Does grandma manipulate you when she adds sugar to her cherry pie? Does she manipulate you when she adds salt to her mashed potatoes? Foods -- "ultra-processed" or not -- don't "manipulate" you. They literally just either taste better or taste worse. Grandma, and her grandma before her, used sug…

Does grandma have a profit motive? Does grandma care about your wellbeing? Is grandma a vast conglomerate of strangers who couldn't give two flying fucks about you on a good day?

Is plain old sugar, animal fat, and salt unhealthy in large quantities? Of course, but eating grandma's mashed potatoes and cherry pie once a week will not materially affect your health. Meanwhile you pass 8 taco bells on your way home from her house, not to mention the 3 fast food ads you heard on youtube or the radio. Come on.

Re: GLP-1 drugs: An economic disruptor? (2024)

#284

Post by lm28469 »

crazygringo wrote: post #278
lm28469 wrote: post #258

Earlier quoted context omitted.

No matter how I look at it 60g of sugar in small bottle of coke is criminal. My wife bakes cakes for 10 people with less added sugar. Junk food definitely is designed to abuse our natural instincts and needs, from packaging to ingredients. Go one year without processed food, you won't physically be able to drink coke or eat fastfood

> No matter how I look at it 60g of sugar in small bottle of coke is criminal. I hate to tell you how much sugar grandma put in her lemonade, and in her sweet tea... > My wife bakes cakes for 10 people with less added sugar. That's extremely unusual. Different types of cakes take different amounts of sugar, but it's generally somewhere between 150g and 300g for an average-sized cake that might give 10 slices. That's…

I guess it's a cultural thing, we always reduce American recipes sugar by 75% or so

Re: GLP-1 drugs: An economic disruptor? (2024)

#285

Post by bdzr »

otterley wrote: post #266
crazygringo wrote: post #260

Earlier quoted context omitted.

Oh, I'm familiar with it. And you know what? They mostly are doing what grandma does. Just in vastly larger ovens etc. Even if you want to talk about corn syrup, what do you think grandma made her pecan pie with? And the things that are different -- emulsifiers, stabilizers, natural/artifical flavors, etc. -- aren't actually making the product unhealthy, at least not in any way that causes weight gain. Those aren't s…

I don’t know if it’s the nature of the products themselves, or if it’s because they’re vastly cheaper and more accessible. There’s a natural limit to the number of cookies to be had from Grandma before she says “that’s enough,” vs being able to get 64 at the local market anytime you want for a pittance.

> I don’t know if it’s the nature of the products themselves

Isn't this what you were just arguing it was not 10 minutes earlier?

Re: GLP-1 drugs: An economic disruptor? (2024)

#286

Post by crazygringo »

lm28469 wrote: post #284
crazygringo wrote: post #278

Earlier quoted context omitted.

> No matter how I look at it 60g of sugar in small bottle of coke is criminal. I hate to tell you how much sugar grandma put in her lemonade, and in her sweet tea... > My wife bakes cakes for 10 people with less added sugar. That's extremely unusual. Different types of cakes take different amounts of sugar, but it's generally somewhere between 150g and 300g for an average-sized cake that might give 10 slices. That's…

I guess it's a cultural thing, we always reduce American recipes sugar by 75% or so

I'm very curious what one of your cake recipes is!

Because sugar also greatly affects the texture of cake -- it retains moisture, prevents gluten formation, incorporates air... reducing sugar by 75% is going to make for a very dry, tough, and dense cake.

I can't even imagine how you're going to make a cake recipe work with 75% less sugar. And it's not an American thing -- it's not like European cakes are any different. Also, cakes don't work with 4x sugar either. Americans aren't overloading sugar that you need to compensate for, because that doesn't work for cakes either.

Are you sure you haven't confused it with just simply less frosting or something? Because a 10-slice cake with less than 60 grams of sugar just isn't really going to work, with everything I know about baking.

Re: GLP-1 drugs: An economic disruptor? (2024)

#287

Post by dang »

Judgmentality wrote: post #224
dang wrote: post #212

Earlier quoted context omitted.

Can you please not harangue another user like this, regardless of how much you feel they should or shouldn't be spending? https://news.ycombinator.com/newsguidelines.html

I asked a question and he ignored it. I asked it again and he answered it. What you call haranguing I call a conversation.

Your comments come across as more aggressive than perhaps you intend them to. We've had to ask you similar things before.

Telling someone that their spending is "fucking egregious" and "who knows what else you didn't mention", would land with most people as quite a provocation. The fact that cj replied courteously says something good about cj, but your comment broke the site guidelines and we need you not to do that.

It's easy to underestimate the amount of provocation in one's own comments—we all do that to some extent. I don't know if it's helpful or not but here are a bunch of past attempts I've made to explain this: https://hn.algolia.com/?dateRange=all&page=0&prefix=true&que...

Re: GLP-1 drugs: An economic disruptor? (2024)

#288

Post by valunord »

no_wizard wrote: post #279
valunord wrote: post #254

Earlier quoted context omitted.

Thanks for experimenting with your body. I'll be sure to check back in about ten years to see how all this shakes out. Keto + intermittent fasting are my magic pill right now and have been for some years.

Ozempic has been in use for diabetic patients for at least a decade if you want to look at the research of its long term results in that population - which is fairly large to constitute a good sample sizing.

So that means we'll have a good twenty years of data to finally look at, which is what I was saying. I do not trust any medicine unless it has far more data than what we have in this regard at this point. I work in a related field and I can simply say most things we trust should not be trusted and should require far more testing.

Re: GLP-1 drugs: An economic disruptor? (2024)

#289

Post by maleldil »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice

Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

Re: GLP-1 drugs: An economic disruptor? (2024)

#290

Post by [deleted] »

dang wrote: post #287
Judgmentality wrote: post #224

Earlier quoted context omitted.

I asked a question and he ignored it. I asked it again and he answered it. What you call haranguing I call a conversation.

Your comments come across as more aggressive than perhaps you intend them to. We've had to ask you similar things before. Telling someone that their spending is "fucking egregious" and "who knows what else you didn't mention", would land with most people as quite a provocation. The fact that cj replied courteously says something good about cj, but your comment broke the site guidelines and we need you not to do that.…

[deleted]
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