The FDA requirements for the original clinical trial were wild: "...the FDA required them to find a cohort of 300 healthy 18-30 year olds who lived alone, not near a school zone, and had fully removable teeth." I can see why this makes sense, but no wonder they failed at enrolling the cohort.
Gene-Engineered Mouth Bacteria
281–290 of 312 posts
Re: Gene-Engineered Mouth Bacteria
#282A conversation with my friend who was a dentistry student, ~2013. > [The friend, let's call her L, trying to dissuade me from drinking some fizzy drink] > J: But I won't get a cavity if the liquid doesn't touch my teeth. > L: Cavities are caused by the ensuing low ph environment, not by contact with teeth > J: Does that mean I can drink as much of it as I want as long as I rinse my mouth with water afterwards? > L, w…
I've done everything the experts have said, we were too poor for sweets, but they have continued to prove themselves wrong. Something I find interesting is the role zinc plays in the oral cavity, a sufficiently high intake see's an increase of zinc in the saliva, which in turn reduces the oral bacteria levels, zinc will appear in the enamel of the teeth, and zinc has a similar oesteoblastic effect with bones where it…
Re: Gene-Engineered Mouth Bacteria
#283The question I always have with this type of stuff is: why is it not _already_ huge. Cavities were a big thing already in 1985. If this was a miracle cure in 1985 then I do not believe that this study would have ended in 'ok that was fun, back to normal life'. This has huge commercial potential if true, so the apparently implications is that there is something blocking that commercial application. Was it FDA? Was it…
Re: Gene-Engineered Mouth Bacteria
#284Earlier quoted context omitted.
Don't want to get too conspiratorial, but dentists make their money on cavities, not cleanings.
If you want to more or less permanently stop gum bleeding pre-brush with a dilute (50 to 200 ppm) solution of hypochlorous acid generated from vinegar acidified salt water (0.8-2%) with salt concentration (saline is 0.8-0.9%) then hit it with a $5 Aliexpress USB electrolyzer for about 30 seconds. The biofilms come right off, your toothbrush ceases to accumulate biological matter, and hypochlorous acid does not begin…
Re: Gene-Engineered Mouth Bacteria
#285So within the existing population today there exist individuals who essentially never get cavities. The hypothesis for this has been 1. they don't eat sugar, or only fibrous foods, etc. 2. They have a genetic difference that builds stronger enamel or similar. I have never heard of anyone discussing bacteria in the mouth as a possible difference. Be interested to see if there is a natural strand that some people have…
I'm 40 years old. Never had cavities. I eat plenty of sugar.
Re: Gene-Engineered Mouth Bacteria
#286Earlier quoted context omitted.
I'm 40 years old. Never had cavities. I eat plenty of sugar.
Yeah, it's always baffled me. Growing up I ate snacks and sugar fiendishly, but only ever had maybe one or two cavities in 2nd grade or so. I had another friend who got cavities on an almost yearly basis. What was really fascinating was how boring her diet was; I never saw her eat anything more complex than a peanut butter sandwich or cheese pizza. She brushed, flossed and mouthwashed every day but could never get ah…
Re: Gene-Engineered Mouth Bacteria
#287Earlier quoted context omitted.
I have very strong (and ugly) teeth. The few "cavities" that I had, were actually made by dentists (they do that, y'know), and have resulted in a couple of crowns. Otherwise, my teeth are great. I now have a dentist that doesn't make cavities, and she seems almost disappointed, when she checks me. But gum care is every bit as important as tooth care (take it from me, you don't want a gum-scraping), and that is why I…
> The few "cavities" that I had, were actually made by dentists (they do that, y'know) You are the only person I have ever heard entertain this idea, so it would be better to spell out how this happened than assume everyone knows it.
Let’s just say that there has been a fair bit of press, over the years on the matter, so it may not be as singular an event as you might think.
Re: Gene-Engineered Mouth Bacteria
#288Earlier quoted context omitted.
If you want to more or less permanently stop gum bleeding pre-brush with a dilute (50 to 200 ppm) solution of hypochlorous acid generated from vinegar acidified salt water (0.8-2%) with salt concentration (saline is 0.8-0.9%) then hit it with a $5 Aliexpress USB electrolyzer for about 30 seconds. The biofilms come right off, your toothbrush ceases to accumulate biological matter, and hypochlorous acid does not begin…
Or just rinse (water pick even better) with a dilute bleach solution (0.25%). Make the solution fresh each time or every 24 hours, since sodium hypochlorite tends to decompose easily. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9292655/
Hypochlorous acid is hundreds of times more effective than bleach as a biocide because it is uncharged and can far more readily diffuse past the lipid bilayer of microbes to wreak havoc. Somehow, humans are generally much more immune to these effects. Whereas 0.1 ppm HOCl can kill most bacteria it takes approximately 10,000 ppm to damage most human cells. It is not recommended to use much over a handful of ppm in the nose and eyes.
Re: Gene-Engineered Mouth Bacteria
#289Earlier quoted context omitted.
Not sure if you are kidding, but death is bad. I assume you don't want to die now, so why would you want to any other time? And don't say 'because I'm old', because obviously aging is part of the problem. Being 20-30 forever is the goal.
Death is not bad - without it life makes no sense. Being 30 forever and immortal would be my definition of hell. Death is doing a great job, leave it alone. Chugging 300 pills per day - you will still die. It is inevitable.
Re: Gene-Engineered Mouth Bacteria
#290A conversation with my friend who was a dentistry student, ~2013. > [The friend, let's call her L, trying to dissuade me from drinking some fizzy drink] > J: But I won't get a cavity if the liquid doesn't touch my teeth. > L: Cavities are caused by the ensuing low ph environment, not by contact with teeth > J: Does that mean I can drink as much of it as I want as long as I rinse my mouth with water afterwards? > L, w…
Yes! Rinsing your mouth REGULARLY after meals does a lot to prevent further cavities. Also a diet high in animal meat and fats (cheese, butter etc.) helps strengthen teeth https://www.healthygoods.com/blogs/news/dr-weston-prices-die... And cutting out sugars - especially fructose - avoids diabetes. Some people who are lactose intolerant cut out lactose, and some people prone to celiac disease cut out gluten. Sometime…
So basically drinking water?