Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Evaluating necessity of Covid-19 vaccination in previously infected individuals

medrxiv.org

Post reply on HN
Print view View original

281–290 of 361 posts

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#281

Post by galoisgirl »

waterside81 wrote: post #70
stavros wrote: post #28

Earlier quoted context omitted.

That's encouraging! I got COVID a few months ago and got vaccinated recently, seems like I should be unstoppable now.

Hey I'm curious, if you don't mind sharing, how do you think you got it? Throughout this whole pandemic, I'm still kind of amazed how people are getting it

Some more anecdata:

- Me: no idea, we were careful :(

- Friend 1: had son in school, son's classmate's father got it and by the time they knew, the kids had met. This was during a wave and contacts weren't tested, only symptomatic people.

- Friend 2: stupid, stupid colleague came to work to pick up laptop when she got quarantined.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#282

Post by astrange »

f6v wrote: post #250
mikedilger wrote: post #10

Earlier quoted context omitted.

Not that I have any knowledge on this subject, but why would a vaccine that stimulates the creation of a bit of spike protein create a "much broader and more durable immune response" than the actual virus which I presume creates a hell of a lot more of that exact same spike protein? Genuinely curious, because my simpleton assumption would be the opposite.

I think the key is that you get 2 shots. The second one might result in antibodies that bind the antigen better. This might happen because the immune cells undergo another round of mutation and selection after a second round of antigen exposure.

It's typically because of the adjuvants added to vaccines, and some other mutations done for stability.

The major covid vaccines have fewer adjuvants (to allow for boosters) and 2 shots because that's just how the trial was run, and it turned out to work, but later testing shows they're pretty effective just with one and some countries have been delaying the second one until everyone gets their first.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#283

Post by thaumasiotes »

nicoburns wrote: post #246
khazhoux wrote: post #215

Earlier quoted context omitted.

"It's just a cough, couldn't possibly be the respiratory disease that's defined the planet for the last year."

It boggles my mind how many people I've heard coughing followed by "don't worry, it's not covid". How on earth would they know?

Well, in my case, because I've been coughing for the last four years.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#284

Post by switch007 »

waterside81 wrote: post #70
stavros wrote: post #28

Earlier quoted context omitted.

That's encouraging! I got COVID a few months ago and got vaccinated recently, seems like I should be unstoppable now.

Hey I'm curious, if you don't mind sharing, how do you think you got it? Throughout this whole pandemic, I'm still kind of amazed how people are getting it

Why exactly are you amazed? Because of the vaccine rollout progress, or people going out and living their lives?

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#285

Post by thaumasiotes »

ping_pong wrote: post #223
jquery wrote: post #166

Earlier quoted context omitted.

As long as the initial infection didn’t kill or incapacitate you. Edit: most bubonic plague infections didn’t kill so I don’t know what the point of “most people survive” is. The problem is that some don’t.

The Black Death, if that's what you're talking about, killed about 2/3 of all Europeans.

I usually see estimates more in the 40-50% range?

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#286

Post by jokethrowaway »

handmodel wrote: post #52
OJFord wrote: post #40

Earlier quoted context omitted.

Because it's not public health policy anywhere that I'm aware of? But vaccine rollout would be way quicker, and 'positive test or vaccinated' proportion of populations would be way higher, and that would influence discussion of other aspects, like 'herd immunity' for example.

My one anti-vax friend (who I make fun of constantly for not getting it) is constantly bombarded with people telling him that his previous infection doesn't give him any immunity. I already knew that was false - and I think he knew that too. It probably fed into his (motivated) reasoning to hold out this long if people are telling him so much information they know to be untrue. Still, I don't see how public health wo…

The only reason I got the vaccine is because of the chance idiotic unscientific governments won't bother me with tests I need to pay for when travelling.

I'm not a "anti-vaxxer" "conspiracy theorist" "racist" "sexist" "nazi" but the risk is just too low for me to care. If you think covid can affect you, take the vaccine and don't bother me. I self isolated weeks before the government told me so because we didn't know what the risk involved was. By the time the government approved a 2 weeks lockdown which turned into 1 year and a half, it was already evident the risks were minimal. This is all a political play and I shudder when I think about what's coming next. Shall we do a climate change lockdown next? Or shall we try some more covid variants first?

I also don't think vaccines are likely to be dangerous (minus the platelets / blood clots issue - hopefully no long term issues pop up in 10 years).

Also, the downside is that everyone is paying for these shots, they're not free and they come out of the taxes the government steals from me every month - and they accomplish very little. Same as the flu shots.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#287

Post by jokethrowaway »

paedubucher wrote: post #226
np_tedious wrote: post #11

I did have covid (not diagnosed while active but shown in antibody test), and I got vaccinated significantly later. This was not driven by belief in medical need, but by social/rules need. You get no "points" for being recovered like you do for a proof of vaccination.

Getting a vaccination just for "the points" looks like a bad idea to me, because "the health" should be the only point to be considered.

Welcome to regulations-ville, where nothing makes sense and clueless bureaucrats decide how many times you need to jump to get your freedom

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#288

Post by timbaboon »

ping_pong wrote: post #231
Reason077 wrote: post #227

Earlier quoted context omitted.

I think if you've had Covid, you'd disagree that its symptoms are similar to other common diseases. It feels quite different from any cold/flu I've ever had - unlike most flus I've experienced, there was no bronchitis, no throat pain, no sinus congestion, only a mild intermittent cough, little snot/phlem, etc. But it has some distinct features: high fever/temperature which lasts < 24 hours, changes in taste (foods wh…

I know some people who got COVID and said they felt fine, except for a stuffy nose. Almost everyone I know that had COVID said that the flu was worse. All the symptoms that you mentioned apply to the flu as well. There might have been one day where they felt really worn out, but that was it. I felt the same way after taking the vaccine. Change in taste can be attributed to blocked nose which radiacally changes the ta…

I’m fit and 33. I run, cycle and do adventure races. I got COVID and bronchopneumonia concurrently a month ago. I was lucky enough to not have to go to hospital, but I can honestly say I have never felt so sick in my life. Never has a flu even come close to that for me. Ofc it hits everyone differently, but this wasn’t “just flu” for me.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#289

Post by jokethrowaway »

joshuahughes wrote: post #20
np_tedious wrote: post #11

I did have covid (not diagnosed while active but shown in antibody test), and I got vaccinated significantly later. This was not driven by belief in medical need, but by social/rules need. You get no "points" for being recovered like you do for a proof of vaccination.

Sounds uncomfortably like coercion...

The government specialises in coercion. Pay your taxes or you'll be fined. Pay your fines or we'll throw you in a cage.

It's time to fight guys from that country or we'll throw you in a cage. Obey our rules or we'll throw you in a cage.

I hope if something good comes up out of covid, it will be people realising that and vote for limiting government's power.

Re: Evaluating necessity of Covid-19 vaccination in previously infected individuals

#290

Post by huffmsa »

cbsmith wrote: post #200
phkahler wrote: post #101

Earlier quoted context omitted.

>> So this study doesn't have enough statistical power to say how vaccines compare to previous infection. Could be better, could be up to 3 times worse within a high confidence interval. Could be. But it would be great if they'd just say having had a confirmed case is equivalent to getting the vaccine because several studies have now shown that to be roughly the case. It's also conventional medical wisdom although it…

Unfortunately, we have reason to believe that over time, the immune defenses from COVID-19 infection seem to decline, particularly in older folks. It'd be great if we had some definitive data on secondary infection rates, but until a lot more people get infected, we just won't have it.

I keep hearing this, but have yet to see evidence that the elderly are catching second rounds at a high rate.
Post reply on HN