Moderna mRNA sequence released to GitHub [pdf]

Post by WJW » Tue, Mar 30, 2021, 8:51 AM UTC

baby wrote: post #274

csense wrote: post #263

The Human Genome Project was completed almost two decades ago, and somebody solved the protein folding problem recently. Why are we still doing genetics at the machine code level? Shouldn't we have some compilers, assemblers and linkers by now?

My thought exactly. So this thing is like a VM with a bunch of primitive opcode, why can’t someone write a higher-level language or at least some gadgets

Post by flobosg » Tue, Mar 30, 2021, 9:01 AM UTC

dooopy wrote: post #272

I compared the spike encoding regions, and it looks like they're quite different...I wonder if the codons wind up coding for different amino acids. And who got it right?

Post by amelius » Tue, Mar 30, 2021, 9:05 AM UTC

wombatpm wrote: post #218

lettergram wrote: post #45

Earlier quoted context omitted.

It really is that “simple.” Getting it designed and building it is more difficult. At its core, it’s a piece of mRNA that creates a protein. That code gets transcribed into a protein (often those are relatively short). That protein then triggers your bodies immune response, which trains it to attack covid19. Inject this mRNA into a cell and it’ll create the protein. Anything can be injected at this point once the mec…

Which makes me wonder. Could you place the entire virus genome in these liposomes and get them to hijack the machinery to make an entire virus? Like plasmid but for viral structures?

Post by aneutron » Tue, Mar 30, 2021, 9:19 AM UTC

Haemm0r wrote: post #242

snuxoll wrote: post #89

Earlier quoted context omitted.

InstallGene by Flexera

Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o

Post by Yizahi » Tue, Mar 30, 2021, 9:23 AM UTC

azernik wrote: post #70

drtz wrote: post #31

I'm sure it's more complex than I grasp as a layperson, but I'm utterly amazed at how simple this _appears_. I get the feeling that this is something I have a better chance of understanding than the average SaaS Terms and Conditions. I expected to have to scroll through pages upon pages of indecipherable text. Instead it's no bigger than a large paragraph of text, and I can easily fit it on my screen.

The protein they're trying to manufacture is indeed quite simple - AFAIU both BioNTech and Moderna put together their sequences in a weekend. (Though there was a more involved process of winnowing down the sequences for the most effective ones.) The technically challenging parts are: - delivery mechanism: you need to take a very unstable molecule, protect it from the environment - both external, and when inside the p…