Live data from Hacker News

What Ozempic does to the gut-brain axis

psychologytoday.com

271–280 of 555 posts

Re: What Ozempic does to the gut-brain axis

#271
post #262

Earlier quoted context omitted.

>But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something. Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat. Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit? Can your body really tell whether y…

> Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit? I know several people who are feeling hungry because they're not dead, regardless of how much calorie surplus or deficit they have. We can do the same activities and eat the same meals and I'll be satied and they will be hungry. Or I can confuse the hell out of them when we do some big activity and I say "i'm not hu…

>I know several people who are feeling hungry because they're not dead, regardless of how much calorie surplus or deficit they have.

Are you saying 1000kcal vs 200kcal deficit makes no difference?

>Diet research would be a lot more interesting if there were ways to classify people by their 'metabolism type' and then see what can work for which type. Maybe there would be more reproducability that way, too.

You can easily track your maintenance calories, by tracking your weight vs intake overtime.

Re: What Ozempic does to the gut-brain axis

#272

Earlier quoted context omitted.

> Diets also don’t stick when you discontinue them. Yes, obviously. Which is why sustainable weight loss takes a commitment to making a change in lifestyle. What’s more sustainable, changing your lifestyle to maintain the weight you lost, or being beholden to taking a drug to maintain that same lifestyle change for a hope at maintenance?

At a large enough scale, being beholden to a drug is far more sustainable. We’ve tried shaming people into being healthy. Amazingly enough, it doesn’t work very well.

You claim shame was tried and was unsuccessful thus we should drug people. But what about the opposite of shame? Education, encouragement, non-judgementalism, and providing all other support required.

Re: What Ozempic does to the gut-brain axis

#273
post #264

Earlier quoted context omitted.

I understand calorie balance. I've been on a diet since I was 12 years old, and am now approaching 50. I've lost and regained the same 60lbs about 4 times now. I have logged every bite that goes into my mouth, and lived with a constant hunger for as long as I could take it. Then I ate until I felt satisfied and gained it all back. I know how many calories are in anything, and I can eyeball any serving size. I've been…

That sucks. If GLP-1s work for you, more power to you. Curious: how big of a calorie deficit did you run, and what was your macro (protein/fat/carbs) balance. My personal experience is going low on carbs (especially added sugars) and high on fiber and protein made running a deficit suck much less in terms of feeling satisfied. Also, a 10% deficit was okay (I was hungry but could mostly ignore it). A 25% deficit was v…

[dead]

Re: What Ozempic does to the gut-brain axis

#275
post #265

Earlier quoted context omitted.

What if you could intentionally eat good food? I've heard it widely described as reducing mental noise around food.

People can get fat by eating too much healthy food.

true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense.

Eating healthy food alone isn't solution, you need to make your life active as well.

Re: What Ozempic does to the gut-brain axis

#276

Earlier quoted context omitted.

At a large enough scale, being beholden to a drug is far more sustainable. We’ve tried shaming people into being healthy. Amazingly enough, it doesn’t work very well.

You claim shame was tried and was unsuccessful thus we should drug people. But what about the opposite of shame? Education, encouragement, non-judgementalism, and providing all other support required.

We've been doing that for a while too - it was Michelle Obama's whole thing, for example?

It could definitely use more support, but it doesn't do a ton if the structure of people's lives is being changed by other factors. (Car based commutes, long work hours, lack of exercise at their job, the cheapness of certain kinds of foods, food advertising.)

If we had a lot more political power to work on public health programs, maybe. But obesity rates are rising throughout the developed world regardless of local culture so there is a ton of work needed there.

Re: What Ozempic does to the gut-brain axis

#278
post #231

Earlier quoted context omitted.

>If it makes someone feel better about themselves to believe in woo-woo science that violates the laws of physics and ascribe magical properties to GLPs, why do you care? Why we should not care about putting people on drug who do can benefit from making lifestyle changes, being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works? if there is no resistance, simply prescribin…

> being less sedentary and leaning about maintenance calories and how calorie surplus and deficit works? Because it's useless advice that doesn't work in practice. As witnessed by decades of failure, with the only thing turning the tide on the obesity epidemic on a population scale being GLP-1 drugs. > if there is no resistance, simply prescribing GLPs to average person may become a new normal. Probably not ideal, bu…

>Because it's useless advice that doesn't work in practice. As witnessed by decades of failure, with the only thing turning the tide on the obesity epidemic on a population scale being GLP-1 drugs.

I think you are looking at research on obese people but applying it to average people who are simply overweight.

Re: What Ozempic does to the gut-brain axis

#279
post #150

Earlier quoted context omitted.

No, the symptom is being treated, not the underlying issue. And that's ok, but treating the underlying issue, when possible, is better, as the problem ceases to exist.

But that's not what the pharma companies want. They want you on the lifetime prescriptions that don't actually address the underlying problem.

Are they hiding true solutions treating the underlying issues?

Re: What Ozempic does to the gut-brain axis

#280
post #265

Earlier quoted context omitted.

People can get fat by eating too much healthy food.

true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.

The glycemic index also comes into play. It essentially measures how much certain foods keeps you full regardless of calories. So healthy food, even if you’re consuming the same calories as junk food, is going to keep you full longer.
Post reply on HN