For me the worst part is how "let me check that email again for context" becomes a 2-minute exercise in 2FA juggling, at the end of which I've already forgotten what I opened my email for and need a coffee break just to calm my nerves.
The worst for me is how the 2FA requires me to use my personal phone. That phone is filled to the brim with notifications from apps and games that were designed to be addictive. I avoid logging into anything because I know it will ruin my day. Before the era of mandatory 2FA the first thing I did when I arrived at the office was turn off my phone and lock it away.
Use a hardware token, then. They are not particularily expensive, and should free you from needing to look at your personal phone at work...