271–280 of 400 posts
>When diazepam medication was stopped, the effects lingered for a while but were eventually reversed.
Also when making a conclusions from this mouse model to a human is how much were they actually giving the mice… a sleep inducing dose could be small or heroic.
>sleep-inducing dosage I don't know why benzos are used for sleep anymore. It's generally a higher dose than what's needed to manage anxiety, so there's increased risk of dependency and you build up tolerance quickly. In contrast, something like a low dose of Seroquel is at least as effective, has a much lower addictions & abuse profile, and tolerance doesn't build up very quickly at all. On top of which there should…
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> I have a hard time believing that while the current status quo is suboptimal, there's some little known compounds that are, as you say, revolutionary and with little side effects. Your suspicions are correct. The parent comment is an example of a trend among people who know just enough about pharmacology to be dangerous: Exaggerating the benefits of less popular medications while demonizing mainstream medications.…
You should probably read about the pharmaceutical industrial complex to balance out your wildly biased and one-sided, unbalanced perspective. Are you honestly going to claim that the many multi-billion dollar pharmaceutical industry doesn't have a financial incentive to lead people toward 1) daily use medications that gives the industry a monthly recurring revenue stream, 2) where many people on them long-term becaus…
Benzodiazepine patents expired long ago. Same with most SSRIs.
If you're suggesting that pharma execs are conspiring to get rich by selling people their $4/month generic Prozac prescriptions, then I don't know what to tell you. I suspect your thinking is motivated more by narratives and conspiracy theories than facts and figures.
> You conveniently also forgot to mention that SSRIs, for example, actually increase the rate of suicide (along with suicidal ideation) - so you're more likely to kill yourself if you take them then if you didn't take them; that is from their clinical trials.
You have NO idea what you're talking about and you're spreading harmful misinformation. The black box suicide warning is for the startup period and is a rare side effect. SSRIs have a net reduction in suicidal ideation.
The patient population who has been prescribed SSRIs is more likely to be associated with suicidal ideation than the general public because SSRIs are prescribed to depressed patients, not the general public.
> Reality is more complex than you're currently aware of.
I'm very confident in my knowledge of these subjects and it's clear from your posts that you've been consuming some alternative medicine propaganda. I hope everyone reading this can see that you're pushing alternative medicine concepts mixed with conspiracy theories, not actual research.
I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
Did you tell your doctor you were taking phenibut when they prescribed you benzos? It seems like something you definitely shouldn't mix. I completely agree that benzos are bad news unless you truly need them. In my relatively uneducated opinion, I don't think they should be a first-line treatment and it's kind of a joke that they're considered schedule 4 (at least compared to things that are schedule 2 - I don't thin…
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here's 438 studies for you https://pubmed.ncbi.nlm.nih.gov/?term=Emoxypine&sort=date the marketing name is mexidol. Emoxypine is a wonder drug for health, it is one of the most potent superoxide antioxidant and has an incredible range of body protective effetcs see e.g. https://en.wikipedia.org/wiki/Emoxypine#Mechanism_of_action look at the pictures and admire the amount of saved brain volume https://www.researchgate…
Interesting. What's the quality of Russian medical research versus western? What journals are considered prestigious? (Not trying to troll -- I honestly have no idea and can't judge it accurately).
Generally speaking - not great. There are some interesting Russian compounds out there that seem to do something, but they always fall way short of the miraculous effects shown in old Russian studies.
Old Russian pharmaceuticals have actually been a gold mine for supplement sellers in the past two decades because they're basically unregulated pharmaceuticals that can be marketed in the United States and other countries while pointing customers to questionable Russian studies to promote them.
If you browse Nootropics forums, you can find scores of people who tried the various compounds. Few people seem to continue any of them for very long either due to lack of primary effects or growing side effects. As I said, the Russian studies paint a very optimistic picture of the drugs.
Look at it this way: If any of these old compounds were really miracle drugs, the big pharmaceutical companies would be rushing to get them to market in the United States with some creative patented exclusivity. But none of them have taken any of these compounds past the early research phases. Similar story in other countries.
Some potentially interesting compounds, but you have to take the studies with a huge grain of salt.
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Peterson is a verified idiot with nonexistent self-control. Not the slightest modicum of it. Basing anything off of his antics is asinine. So weird to see people who put him on a pedestal on HN. & benzos aren’t “horrible drugs” People who don’t know how to manage themselves and their usage of them are horrible people though, especially when they try to cut down others who have no issues using them responsibly, which…
> which sometimes literally saves their entire lives. considering how benzos came into existence barely half a century ago, i highly doubt not having benzos as part of one's pharmaceutical cocktail is the fundamental difference maker to one's life or death. so even to those who are now dependent on them, their long-term health will almost certainly be better served by getting to the root cause of their health issues.…
Dude, I've spent my entire 20s in therapy while trying various "safe" drugs to get ahold of my anxiety issues. Nothing worked. I was offered electroconvulsive therapy or daily benzos. I went with benzos. I've been taking them for years now and my life is infinitely better as a result. I've changed careers, gotten married, and traveled the world. Before benzos I was living with parents, too anxious to go across the street to get the mail.
I really don't think it's right to dismiss a whole class of highly effective and generally safe medication that can have life-altering benefits for some people. I'm okay with being slightly more retarded in my later years if it means I actually get to live a life outside my parents' basement.
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It's sort of a sad indictment of our system, but odds are the pharmacist sees the patient far more than the psychiatrist does.
Comments like these are baffling. Where are people finding these psychiatrists who are blindly writing prescriptions and sending people out the door? Around here (US location) my medical professional friends are all hesitant to prescribe any controlled substances to more than a certain number of their patients for fear of getting flagged. Whenever I read these stories of people receiving benzos and other scheduled su…
I saw multiple doctors for years about anxiety issues and the most I got prescribed was an antihistamine. I also suffer from chronic back pain due to a genetic issue and it's been pretty much impossible for me to get a prescription that does anything for it.
I don't think people are lying about their experiences, I'm just baffled as to where this is going on because it's been totally opposite to my experiences.
As a PSA, something to be aware of is the stimulant paradox for anxiety due to ADHD. Typically anxiety & stimulants would be a no-go combination, but for folks with ADHD-induced anxiety stimulants can actually help. I know someone whose child was (finally) properly diagnosed with ADHD only after they let their child try a tiny bit of their coffee and there was a significant change. It was the revelation needed to get…
FYI - The idea that stimulant response can be used as a diagnostic tool for ADHD is a myth. No researcher or professional who studies the subject actually takes that seriously. Nobody should be interpreting their response (or a child’s response) to stimulants as a diagnostic indicator for ADHD. It’s also worth noting they caffeine isn’t an effective ADHD treatment (it had been studied) and caffeine and Adderall don’t…
Also, yes-- caffeine isn't a great treatment here either. With respect to ADHD there are more effective methods.
Related research:
https://pubmed.ncbi.nlm.nih.gov/6110701/#:~:text=The%20admin....
https://psychcentral.com/blog/adhd-millennial/2018/06/when-s...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617411/
https://www.psychiatryadvisor.com/home/topics/child-adolesce...