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Japanese scientists develop vaccine to eliminate cells behind aging

japantimes.co.jp

271–280 of 382 posts

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#271

Earlier quoted context omitted.

In an ideal world. Even if we achieve longevity with this approach, we can't use it for everyone. People need to die now more so than ever, where would we put them otherwise? The whole idea behind the current pandemic is that people need to die, via vaccines, or the virus, or the media.

Why do people need to die now more than ever ?

There's queues everywhere

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#272
post #268

Earlier quoted context omitted.

It’s an interesting idea, but how would you measure happiness? For example coal pollutes, so at first glance maybe coal plants should get a negative happiness index. Then some plants close, and heating costs go up and people get cold because they can’t afford the electric heat in their homes. Are they happier without the coal? Would they be happier with the coal and the pollution? Does this solve the problem in a way…

If people can look and feel young for a very long time they will be very happy…

I don’t disagree, but I’m not sure how this relates to measuring GDP vs measuring happiness.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#273
post #153
post #42

Here's the paper: https://www.nature.com/articles/s43587-021-00151-2

It's an odd protein they're hitting - GPMNB is expressed pretty widely, so I wonder what the proteoform is that they're targeting/recognising here. Can't get to the paper using all the usual tricks, so it's hard to say what exactly they're immunising with, which could answer a lot of my questions.

GPMNB seems to be expressed in cancer cells. Cancer cells are usually kind of screwed up and senescent. Maybe it's one of those little anti-cancer Rube Goldberg machines like p53 that starts popping off triggering apoptosis when things get weird in the cell.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#274

Earlier quoted context omitted.

Barely have any acute risk. Its almost impossible to find out what happens after long time, say a decade, with the current approach. > The biggest harm done by taking vaccines you don't really need is probably that the money could have been used for something more useful. What kind of nonsense is that? Its the same as saying "there is no problem in taking any drug, the worst it can get is lose some money". You can't…

> say a decade, with the current approach. what could happen a decade after taking a vaccine?

Shingles happens decades after getting chickenpox. Conceivably an atennuated (or live) virus immunization could have a similar future issue.

Lots of other possibilities of immunization causes a small but unnoticed inury that later on proves to be fatal, but because of the gap between injury and fatality is very hard to track down.

My son participated in a 'long term' vaccine trial of a slightly different combination of childhood vaccines (if it had been successful in the US, it would have reduced the number of needles by one, but I don't recall the specifics). But long term means they followed up for one year.

It's just not really possible to keep track of participants for very long outside of very small studies. Maybe if one day we have decent medical records, it will be easy to run epidemiological studies and find small effects. But you would need to make the decision on the immunization with the known information; maybe 20-40 years later you might find out that it increased or decreased the likelyhood of some disease in old age.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#275

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

> Even if it's only 10 more years of quality life, this is the greatest good that could be done for humanity

Why would that be your conclusion? It's 10 more years of life. It's not 10 more years of better life. It's a little more of the same.

That 10 years is "experienced" as only a short increase in local time. Whereas before 33% of your life would have been 28 years old, afterwards 33% of your life would be at 31 years old. So life events would happen a couple years sooner or later but you wouldn't feel the difference.

It's not like world hunger would end. In fact we would need more food, because more humans would be alive at any point, because people are dying later. The senior citizen voting block would increase, expanding the lobbying power of senior citizens, which has a disproportionate unfair effect on the young. Which will get interesting as time goes on seeing as the birth rate has been declining steadily.

It also means your retirement would not last long enough anymore, meaning you would either have to work longer or harder or save more in order to retire. Social security dates would also have to change, and paycheck contributions may even have to increase. But corporations won't want to increase wages (as they never want to) so your money won't go as far in retirement, and inflation would act on it over a longer time, reducing it further than before. And since it would be a voluntary vaccine, as we have seen from the COVID-19 insanity, just having a life-saving vaccine available is no guarantee people will take it. So there would be controversy over whether to extend social security, and some significant amount of the population is going to get screwed over.

Finally, as the wealthy will live even longer, more wealth will get tied up in private ownership for longer, extending the wealth gap. Copyright would also take even longer to expire as it's based on how long since the creator died. There's tons of other random ways that arbitrarily extending the life of a portion of the population will not immediately lead to the greatest good that could be done for humanity.

Call me crazy, but I think we could do much more good for humanity today than just making it take longer for them to die.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#276

Earlier quoted context omitted.

In an ideal world. Even if we achieve longevity with this approach, we can't use it for everyone. People need to die now more so than ever, where would we put them otherwise? The whole idea behind the current pandemic is that people need to die, via vaccines, or the virus, or the media.

Why do people need to die now more than ever ?

We are currently at the brink of extinction, ironically by overpopulation. Everyone knew rapid growth is unsustainable, with 7.9 billion people on earth right now, we are causing more: Carbon emissions, global warming, pollution, environmental damage, ozone depletion etc.

Soon we won't have a planet to live in. I am sure mother nature will find more subtle but beautiful way to eradicate us.

But, hopefully we leave this small planet and explore other planets in near future.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#277
post #268

Earlier quoted context omitted.

It’s an interesting idea, but how would you measure happiness? For example coal pollutes, so at first glance maybe coal plants should get a negative happiness index. Then some plants close, and heating costs go up and people get cold because they can’t afford the electric heat in their homes. Are they happier without the coal? Would they be happier with the coal and the pollution? Does this solve the problem in a way…

If people can look and feel young for a very long time they will be very happy…

Older people are happier than younger people, pretty much every such survey confirms it. Young people don't appreciate their looks and health when they have it.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#278
post #70
post #4

Earlier quoted context omitted.

It's probably not a good idea to get every single vaccines that's not recommended to you by the CDC/your doctor. Vaccines could potentially trigger some dangerous side effects, however rare it is.

Definitely. We have a tremendous amount of risk aversion these days and a culture that has disdain for risk, even calculated abstract risks. What many don't realize is being too risk averse comes with its own risks, it also requires accurate risk assessment so you can make the correct decisions on when to take a risk and not. You could lockup in complete fear akin to analysis paralysis where non-zero risk keeps you f…

> TB, tetanus, and rabies may be useful vaccines for some professions or life exposures in high risk cases,

Not taking away from your main point, but Tetanus is generally recommended once every ten years (or on potential exposure five years from last vaccination). I wouldn't put it in the same category as those other diseases.

https://www.cdc.gov/vaccines/hcp/vis/vis-statements/td.html

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#279

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

> Even if it's only 10 more years of quality life, this is the greatest good that could be done for humanity Why would that be your conclusion? It's 10 more years of life. It's not 10 more years of better life. It's a little more of the same. That 10 years is "experienced" as only a short increase in local time. Whereas before 33% of your life would have been 28 years old, afterwards 33% of your life would be at 31 y…

Also, stagnation as the ruling class, politicians, CxOs, artists, singers, authors, researchers and professors have longer to propagate their outdated mindsets. Paraphrasing Planck, "Science progresses one funeral at a time". Death makes room for the new.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#280

I just turned 19, and I hope. To God that I'm young enough that when this stuff comes to market I won't be so old I can't use it

When I was your age I too wished that such medical breakthroughs would help me live a little longer. As I got to my mid 30s I started wishing that it'll hopefully help my parents live a little longer and enjoy their time with grandkids.
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