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Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

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271–280 of 318 posts

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#271
post #110

Earlier quoted context omitted.

>WE DO NOT NEED PILLS! >Yes, I am yelling. If pills work then what's the problem? It seems to me that you're making an appeal to nature ( https://yourlogicalfallacyis.com/appeal-to-nature ). Given all the health problems associated with obesity from cancer to cardiovascular problems then whatever side effects the pills have are probably negligible in comparison. > Weight management isn't at all about eating less. It'…

Assuming obesity is largely due to mental issues like stress eating, the solution should also be a mental one. It's basically an addition. Most people are perfectly capable of quitting but don't because it's easier not to. This includes myself. I recently put on a bit of weight and I know exactly why: second servings, having a few beers, difficulties sticking to a diet with kids and dietary allergies in the house, no…

> for people who don't have the willpower pills is probably the best solution.

Even for those, should'nt the solution be a stronger detox, intervention, stricter regimen to have external help in supplementing their willpower, etc?

Should'nt this be preferred over pills?

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#273

Earlier quoted context omitted.

I said that you may be an extreme outlier. You're also larger than every NFL player in history, everyone in World's Strongest Man, etc. A 10 mile jog (let's say 80-100 minutes of uninterrupted running) is the sort of "I could eat 50 eggs" number people pull out. At 6'5", you are an outlier. 2kcal is too low, much as it's too high for the average woman. This doesn't mean that metabolism is a "colloquial" term. It mean…

> It's that "I cut calories and I lost weight" is not anecdotal. It's factual. It simplifies the problem though, because for many, that approach has side-effects that seriously affect quality of life, like sleep, concentration, mood swings, depression etc. Speaking of depression, I often get a similar vibe in those threads, where undoubtedly someone will jump in and say "all you have to do is lift heavy weights and c…

If calorie restriction is causing those side effects, it is an indicator that the person is "doing it wrong" by either restricting their intake far more than is healthy or more likely their diet is very sub optimal (eg, 100% carbs causing blood sugar to spike and then crash when they "run out" of calories).

These are problems of application which are easy to fix with a food journal and perhaps a bit of research, not really a great argument against calorie restrictions effectiveness.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#274
post #109

Earlier quoted context omitted.

i’m in a similar spot as the OP. lifting helps, but i’m still pretty fat. 5’11” 250lbs. worksets are 355lb squat, 225lb bench, 425lb deadlift, 175lb overhead press. it’s hard to tell i’m strong, but i’m slightly more slender at this weight than i was before lifting. it definitely helps with aches and pains i used to have, primarily back pain.

Those are some tasty numbers.

haha, thanks. happy with the strength, not happy being 250lbs.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#275
post #272

Im genuinely curious: how much different is obesity in women?

Biologically: mostly similar, although some important hormonal differences. More research coming on this.

Psychologically & socially: very different.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#276

Earlier quoted context omitted.

GPs approach will work for almost all people, if they actually do it.

[citation needed]

How about this for citation:

https://en.wikipedia.org/wiki/First_law_of_thermodynamics

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#277
post #77

Earlier quoted context omitted.

I tried fasting and a pure keto diet. While they do work, I felt miserable. This is not sustainable for people like me who has to lose more than 100 pounds. Now I started losing weight by just balancing macro-nutrients; more protein, more vegetables, less carbs as opposed to absolutes "no" and "only" except for no sugary drinks and beer and deserts except in social occasions. Also big emphasis on weight lifting as op…

I felt miserable on Keto the first two times I tried it. I’ve found doing fasting in the month prior helped with the adaptation and a large part of the misery was loss of electrolytes. By using electrolyte powder I only really had one or two really miserable days this time round.

Very interesting. I'll try it out with electrolytes. What did you take as electrolytes supplement?

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#278

Earlier quoted context omitted.

> Assuming obesity is largely due to mental issues Obesity increased with the increase of meal size, average caloric intake and urbanization based around cars.

Correct that there are a host of causes, certainly not simple.

It is simple. Calorie intake increased while calories spent decreased; creating energy surplus which is then stored in fat. The causal relationship between obesity and mental health is also not clear.

Re: Launch HN: Fella (YC W20) – Tackling men's obesity using medication and coaching

#279
post #166

I am curious if this question has come up in company marketing discussions. One of the most common and off-putting things about the weight-loss industry is the vague medicine promise. Have you considered just saying "semaglutide" instead of "a breakthrough medication"? I honestly almost stopped reading because it comes off as so huckster-ish to me.

I think a lot about our framing and I know for sure we haven't nailed it yet. It's fair to say your avg HN reader is very different to your avg American. For example, you seem already somewhat clued up about Semaglutide. You're likely interested in the biology behind it, and probably aren't afraid to parse the journal article about it. I really wanna emphasize how different this is to your avg American. So it's more…

I've never heard the word "Semaglutide" before this moment in my life. However, to me naming the thing sounds like "people that did at least some of the homework, and I could probably look it up and see if it's interesting to me", and calling it anonymous "breakthrough medication" sounds like yet another scam that tries to suppress my rational brain and get money out of me before I had time to think if it's worth it. It literally does nothing to inform me or to make me think I may be interested - everybody who can hire a copywriter has "breakthrough something", and I certainly don't have time to pay attention to dig up real information on all of them.

I understand that the hustle is a part of the marketing. But medicine is not the area where you should lean on it. At least not on it alone. If you don't give me full and verifiable information about what you have, I won't be interested. Too many scams around and too high risk, especially with the new and yet unproven stuff.

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