Earlier quoted context omitted.
Civ 6 has a native port to Linux. Why do you need Windows?
I was unaware, I just assumed that it was running on proton since I was having issues with it. But the culprit to it not working was having some mods enabled that disabled the menu when running on Linux. Thanks for getting me to take another crack at getting it running!
Civ 4 runs on wine, but the Beyond the Sword expo needs workarounds to work (some few winetricks commands). Does not run out of the box.
Civ 4 Colonization works out of the box but occassionally it will hang.
I have not tried Civ 3 or previous civs.
FreeCiv/FreeCol can be fun too if you don't mind the graphics. Especially the online play. The diplomacy is different.