Live data from Hacker News

Ozempic shows anti-aging effects in trial

trial.medpath.com

261–270 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#261

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly. There's also something to be said for gaining the discipline to do it yourself along the way, which may lead to keeping more of the weight off in the long run. We also don't know what the long term side effects of it will be, if any. I don't find…

> We also don't know what the long term side effects of it will be, if any.

What are the long term side effects of NOT taking it? The article implies it could be early death.

Re: Ozempic shows anti-aging effects in trial

#262

Earlier quoted context omitted.

[flagged]

The zeitgeist has pushed the idea carbs/grains and sugar are terrible over the last 40 years on and off, so that seems to say more about the medical industrial complex, than anything. That's fair, but if that message has been pushed so consistently, why didn't we see a real decrease in the consumption of those things and the associated weight loss?

[deleted]

Re: Ozempic shows anti-aging effects in trial

#263
post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

You don't think her being 87 might have something to do with her complications?

Well also short term complications don't imply long term complications.

If you're allergic to peanuts it doesn't mean everyone is going to suffer some huge medical crisis from peanuts in 20 years.

Re: Ozempic shows anti-aging effects in trial

#264
post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

You don't think her being 87 might have something to do with her complications?

It is a well Mongolian effect of Ozempic.

She stopped using the drug and the problems disappeared.

Re: Ozempic shows anti-aging effects in trial

#265

Earlier quoted context omitted.

> Haven’t these types of drugs been in use for ~15 years? The predecessor of semaglutide, liraglutide has been sold since 1998. GLP-1 has been studied since the 70s. The first human was injected with GLP-1 agonists in 1993 IIRC.

Further, Ozempic itself is nearly 10 now and some people have been on Exenatide for 20+ years continuously now. These drugs are not novel, or new and we absolutely know the long term health impact.

20 years isn't a lot of time

Re: Ozempic shows anti-aging effects in trial

#266

Earlier quoted context omitted.

[flagged]

[flagged]

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything.

At most a drug rep comes by and brings donuts or something to talk about their new drugs.

Source wife is a doctor.

Re: Ozempic shows anti-aging effects in trial

#267

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of Ozempic. Once he saw what stopping the cravings for certain foods can do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird bionic arm implant.

Lol, a glucose monitor is a bionic arm implant (for $200 total), and an injection disrupting your entire hormone system is what then?

[deleted]

Re: Ozempic shows anti-aging effects in trial

#268
Note that these results probably apply to Mounjaro/Zepbound as well, because they are the most effective GLP1s on the market right now:

https://glp1.guide/content/semaglutide-vs-tirzepatide-clinic...

My bet is on the reduction in inflammation -- it's a notoriously beneficial positive side effect of GLP1 Receptor Agonists, along with the obvious reduction in weight or HbA1c.

Re: Ozempic shows anti-aging effects in trial

#269
post #54

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

We think obesity is basically going to be gone in This is going to accelerate when every one and their mother (with industrial capacity) starts making generic Ozempic/Wegovy (Semaglutide) next year due to Canada's patent protection lapse[0].

https://glp1.guide/content/novo-nordisk-patent-protections-l...

Re: Ozempic shows anti-aging effects in trial

#270

Earlier quoted context omitted.

If I told you billions of people eat bread, sugar and pasta and it wasn't "basically killing them" (whatever that means)... It's strange to make the culprit of a modern epidemic foods that have been with us for millenia.

Billions of people were not overweight when they ate those things. They did not eat them 3+ times a day. I said in my other posts.. if someone needs help maintaining or gaining weight, eat those things. If you are overweight, you should be eating ZERO of them. "Basically killing them" means whatever the current obesity and type 2 diabetes epidemic means.

You don’t think people ate carbs 3 times a day in the past? The majority of humans for the majority of recorded history have eaten some kind of bread, rice, potatoes, porridge, or corn with the majority of their meals.
Post reply on HN