261–270 of 553 posts
GLP-1 Agonists, Senolytics, NMDA Modulators, Hormones and Peptides, NAD+ and mTOR Modulation, Nootropics and Adaptogens…
Forget weight loss. These people are going for immortality.
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No brain fog. I walk at a very brisk pace ~6 miles a day. My calories are far less than before I started. I have to be very careful to have enough protein. When I exert myself, the recovery period is the same time as before.
Do you have any idea of how many calories you eat per day? I get so confused because the small amounts of food that people talk about eating on GLP, don't seem like enough to sustain themselves long-term. Are they exaggerating? Or do they talk about not eating dinner, but that's because they had 1,700 calorie lunch at the burger place? Or is that just during weight loss, and then once a target weight is hit, they're…
They are probably losing muscle mass!
I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…
I am 8 months in, you do develop a tolerance over time to the drug (and why you need to increase the dosage progressively). I have gone up slower than the prescibed steps but still, this drug is to help doing diets, I don't think it would work as a long term medication. And as far as I can tell, when you get off the drug or have become tolerant to the current dosage, it is easy to gain back some weight if you are not…
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What does this even mean? The results of GLP-1 meds are well studied and widely understood to be game changing and likely revolutionary. The other claims might be hyperbolic but results of the medication on individuals is not really a question at this point.
I think some skepticism is warranted. If this is a medication that most of us can be on and it comes with positive health benefits, that would mean that humans as a species have lower than optimal GLP-1 levels. I guess it’s possible that our bodies are wired for a world that is unlike today’s and that these drugs correct for that. But drugs that doesn’t come with side effects. It also wouldn’t be the first time that…
The constant access to unlimited tasty food we have now is completely unprecedented in human history.
Other animals will also overeat if you give them unlimited access to tasty high calorie food.
This is absolutely a situation we did not evolve to be able to handle unfortunately. Lack of sufficient food was the norm for most of our history, so it's not surprising that we evolved to want to eat a calorie surplus if possible.
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> Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month... So they are going to force you onto a higher dose?!
Yes, up to 15 mg. Maintenance levels at 5, 10, and 15. If you cannot tolerate a maintenance level you can still get it, but insurance will not cover it ($1000/mo rather than $15/mo.) This is not an unreasonable situation. https://www.goodrx.com/zepbound/dosage
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You should visit a food processing plant sometime. What they are doing with food is not what your grandma does when she cooks it from ingredients you can buy at the grocery store. And I bet your grandma doesn’t have a food chemistry lab to fine tune her recipes. Similarly, fig trees don’t make Fig Newtons. They make figs.
Oh, I'm familiar with it. And you know what? They mostly are doing what grandma does. Just in vastly larger ovens etc. Even if you want to talk about corn syrup, what do you think grandma made her pecan pie with? And the things that are different -- emulsifiers, stabilizers, natural/artifical flavors, etc. -- aren't actually making the product unhealthy, at least not in any way that causes weight gain. Those aren't s…
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Oh, I'm familiar with it. And you know what? They mostly are doing what grandma does. Just in vastly larger ovens etc. Even if you want to talk about corn syrup, what do you think grandma made her pecan pie with? And the things that are different -- emulsifiers, stabilizers, natural/artifical flavors, etc. -- aren't actually making the product unhealthy, at least not in any way that causes weight gain. Those aren't s…
I don’t know if it’s the nature of the products themselves, or if it’s because they’re vastly cheaper and more accessible. There’s a natural limit to the number of cookies to be had from Grandma before she says “that’s enough,” vs being able to get 64 at the local market anytime you want for a pittance.
That's my point. It's got nothing to with supposed "manipulation" of ingredients.
It's about other stuff -- whether it's price or accessibility or someone telling you "that's enough".
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People who don't need to be chronically medicated should not be. There are always side effects, and we don't even know for sure what the long term risks of these medications are yet. And crowing about saving $200/mo not buying food at Starbucks, well now Novo Nordisk is getting that. Toast a bagel at home for $0.50/day instead.
> People who don't need to be chronically medicated should not be. If they're like typical westerners, they already self-medicate with coffee every day, with alcohol occasionally, and a big fraction of them (though much less than couple decades ago) also treat themselves with tobacco smoke - and ironically, weight loss is one of the few benefits some people actually use to defend their smoking. Do they need all that…
The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…
There are some signs that these drugs have effects beyond just apetite supression leading to weight loss. I recall reading something about them having a direct slowing effect on the metabolism, which increases longevity, among other benefits. I can foresee it being used like a supplement among those who can afford it.