261–270 of 318 posts
I am curious if this question has come up in company marketing discussions. One of the most common and off-putting things about the weight-loss industry is the vague medicine promise. Have you considered just saying "semaglutide" instead of "a breakthrough medication"? I honestly almost stopped reading because it comes off as so huckster-ish to me.
Interesting offering, definitely an important market. > So we started researching effective, evidence-based treatments for obesity Fasting has a tremendous amount science supporting it [1], can you articulate why you're pursuing the prescribed semaglutide approach instead? [1] Fasting: Molecular Mechanisms and Clinical Applications https://www.sciencedirect.com/science/article/pii/S155041311...
Spot on about fasting, and keto has solid evidence as well - https://www.virtahealth.com/ are a great company focused on this. The issue is we're starting to have a more nuanced understanding of the metabolic resistance people face when they undergo dietary changes - basically the body fights hard against you as you try to lose weight by dieting. So it's now industry-standard among obesity specialist doctors to see o…
Earlier quoted context omitted.
It's more that the muscles (assuming same muscle mass) have to do comparatively more work if they are carrying around more weight.
That is true but I don't think that accounts for all the metabolism. There's probably something to say about having to maintain your temperature, but I don't know if it consumes more or less energy in general as fat isolates. Wikipedia ( https://en.wikipedia.org/wiki/Basal_metabolic_rate ) says that 70% of the metabolism comes from the organs, 20% the muscles and 10% thermogenesis. All probably grow as you gain weigh…
Yep we're British founders so would love to expand to Europe in the future. Sadly won't be for a couple of years though - lots of work to be done first in the US!
Earlier quoted context omitted.
Spot on about fasting, and keto has solid evidence as well - https://www.virtahealth.com/ are a great company focused on this. The issue is we're starting to have a more nuanced understanding of the metabolic resistance people face when they undergo dietary changes - basically the body fights hard against you as you try to lose weight by dieting. So it's now industry-standard among obesity specialist doctors to see o…
This has been so true to me. At the beginning of the pandemic I started keto. The first six months the weight fell off then I just hit a wall right around the time I began exercising (a full season of skiing) and weight lifting. For the last month I've been combining keto with IF and I'm getting a tiny bit of headway. My body just seems to be fighting VERY hard to resist my best efforts. And while I'm not checking to…
If you're interested in some research behind this:
"Long-term persistence of hormonal adaptations to weight loss" - [1] and [2] are both interesting papers on this. With the summary being that weight loss results in prolonged changes in your hormones associated with increased appetite and thus weight regain. This results in a strong negative feedback cycle.
[1] https://pubmed.ncbi.nlm.nih.gov/22029981/ [2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5764193/
tldr: our bodies make it v difficult for folks!
I am curious if this question has come up in company marketing discussions. One of the most common and off-putting things about the weight-loss industry is the vague medicine promise. Have you considered just saying "semaglutide" instead of "a breakthrough medication"? I honestly almost stopped reading because it comes off as so huckster-ish to me.
Or medicines which have really long and strong evidence for weight loss effects like amphetamines?
TRT clinics are grossly overpriced, charging $300+ A month for $5 drugs, so there is almost certainly room to disrupt that market. I’d be willing to wager many obese men display hypogonadism too.
Would have loved to know you're only live in Texas before I went through the ~10 page survey about all my personal information.
Really sorry about this. We tried to make this clear in the post, but you're right we can definitely make this clearer on our website. Before launching on HN we haven't had an non-Texas traffic so there are some bits we need to change to our infra!
Earlier quoted context omitted.
That is true but I don't think that accounts for all the metabolism. There's probably something to say about having to maintain your temperature, but I don't know if it consumes more or less energy in general as fat isolates. Wikipedia ( https://en.wikipedia.org/wiki/Basal_metabolic_rate ) says that 70% of the metabolism comes from the organs, 20% the muscles and 10% thermogenesis. All probably grow as you gain weigh…
Really nicely put. Yep we're British founders so would love to expand to Europe in the future. Sadly won't be for a couple of years though - lots of work to be done first in the US!
Earlier quoted context omitted.
Really sorry about this. We tried to make this clear in the post, but you're right we can definitely make this clearer on our website. Before launching on HN we haven't had an non-Texas traffic so there are some bits we need to change to our infra!
What are your plans for the information that got filled out on the form, though?
I am curious if this question has come up in company marketing discussions. One of the most common and off-putting things about the weight-loss industry is the vague medicine promise. Have you considered just saying "semaglutide" instead of "a breakthrough medication"? I honestly almost stopped reading because it comes off as so huckster-ish to me.
Or medicines which have really long and strong evidence for weight loss effects like amphetamines?
Earlier quoted context omitted.
Or medicines which have really long and strong evidence for weight loss effects like amphetamines?
Or testosterone, which isn’t necessarily great for weight loss, but is fabulous for body composition, which I’m sure many men would be satisfied with. Weighing 200 with 18% body fat is probably more attractive to many tall men than weighing 160 with the same body fat. Muscle also raises basal metabolic rate which is nice for fat loss. TRT clinics are grossly overpriced, charging $300+ A month for $5 drugs, so there i…