Why not in fasta format?
Moderna mRNA sequence released to GitHub [pdf]
261–270 of 389 posts
Re: Moderna mRNA sequence released to GitHub [pdf]
#262If my little knowledge from biology class serves me correct, RNA uses Udenine instead of Thymine. But in this document it uses T. Can somebody explain to me why?
You probably mean uracil, not udenine (which doesn't exist AFAIK).
Yeah, English is my second language. I just thought of a Translation that sounded reasonable rather than looking it up.
Re: Moderna mRNA sequence released to GitHub [pdf]
#263The Human Genome Project was completed almost two decades ago, and somebody solved the protein folding problem recently.
Why are we still doing genetics at the machine code level? Shouldn't we have some compilers, assemblers and linkers by now?
Re: Moderna mRNA sequence released to GitHub [pdf]
#264The Human Genome Project was completed almost two decades ago, and somebody solved the protein folding problem recently. Why are we still doing genetics at the machine code level? Shouldn't we have some compilers, assemblers and linkers by now?
I feel this XKCD describes the situation particularly well: https://xkcd.com/1831/
Re: Moderna mRNA sequence released to GitHub [pdf]
#265Where is the 5G stack?
Re: Moderna mRNA sequence released to GitHub [pdf]
#266Where is the code about 5G modem?
Re: Moderna mRNA sequence released to GitHub [pdf]
#267ELI5, Why are the sequences different if they result in the same spike protein?
Maybe one could compare it to having different recipes for the same cake. Or different source code to solve the same problem.
Re: Moderna mRNA sequence released to GitHub [pdf]
#268Earlier quoted context omitted.
Why haven’t viruses or bacteria evolved to use a lipid nano particle to evade the immune system? Seems like a big security flaw in our cells?
I remember someone coming up with a song to encourage people to wash their hands more thoroughly much earlier in this pandemic. https://twitter.com/vesselofspirit/status/123748864242514739... According to the song lyric, "novel coronavirus / has a lipid outer shell". So it seems like some viruses have taken advantage of this.
Yeah I think that's the reason for the 20-30 second wash since it takes time for the soap to break down the fatty layer.
Re: Moderna mRNA sequence released to GitHub [pdf]
#269Earlier quoted context omitted.
> I have a "I'm sure that means something to somebody" feeling. Break it down! It's not so bad: > A composition A bunch of stuff > a messenger ribonucleic acid (mRNA) mRNA are cellular instructions on how to make proteins that are read by ribosomes that make those proteins as they read along. > an open reading frame This is something that starts with a "start codon" and ends with an "ending codon" and encodes valid i…
Why haven’t viruses or bacteria evolved to use a lipid nano particle to evade the immune system? Seems like a big security flaw in our cells?
They have. That spike protein is part of their envelope ("nanoparticle").
The envelopes used in an RNA vaccine are generally simpler, because they're working under different constraints than viruses. For example, their envelopes don't need to be easily manufactured in a cell.
But some RNA and DNA vaccines do use viruses as their delivery mechanisms, eg the J&J COVID vaccine.
Re: Moderna mRNA sequence released to GitHub [pdf]
#270ELI5, Why are the sequences different if they result in the same spike protein?
Different codons can encode the same amino acids, so different sequences can encode the same protein.