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Vitamin D deficiency and Covid-19 mortality [pdf]

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Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#261

Post by lhl »

devaboone wrote: post #191
cactus2093 wrote: post #175

Earlier quoted context omitted.

Would you still consider 5,000 IU of Vitamin D per day safe as far as these calcium issues go? I had a doctor tell me to take that dose for at least a few months a few years ago after low levels in my bloodwork during the winter. But I've never known if I should lower the dose to take on a continuing basis or adjust during the summer when I get a little more sun (but I still work in an office/at home so spend a lot o…

I do see people get high calcium levels after being on this dose for years. But not always. You may be able to handle that dose. If you are getting "routine" labs done, then there is likely a calcium level in there. If your calcium is normal (under 10.0 mg/dl for adults over 40, younger adults can be a little higher), then your Vitamin D dose is ok... but I would still recommend coming down a bit on that dose. It is…

Curious on your thoughts/experience with dosing w/ co-factors wrt to calcium levels (for patients, have you been tracking these?)

Specifically, Vitamin K:

Ballegooijen, Adriana J. van, Stefan Pilz, Andreas Tomaschitz, Martin R. Grübler, and Nicolas Verheyen. “The Synergistic Interplay between Vitamins D and K for Bone and Cardiovascular Health: A Narrative Review.” International Journal of Endocrinology 2017 (2017). https://doi.org/10.1155/2017/7454376.

And Magnesium:

Uwitonze, Anne Marie, and Mohammed S. Razzaque. “Role of Magnesium in Vitamin D Activation and Function.” The Journal of the American Osteopathic Association 118, no. 3 (March 1, 2018): 181–89. https://doi.org/10.7556/jaoa.2018.037.

I'm also curious on your thoughts on what you consider high for supplementation, vs say sunlight exposure, as a single MED of sunlight exposure is equivalent to about 10-25K IU of oral supplementation.

Engelsen, Ola. “The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status.” Nutrients 2, no. 5 (May 4, 2010): 482–95. https://doi.org/10.3390/nu2050482.

On the flip side, I've seen that in a recent RCT, that recommended sun exposure guidelines were not sufficient in reversing deficiency:

Lee, Yu-Mi, Se-A Kim, and Duk-Hee Lee. “Can Current Recommendations on Sun Exposure Sufficiently Increase Serum Vitamin D Level?: One-Month Randomized Clinical Trial.” Journal of Korean Medical Science 35, no. 8 (January 22, 2020). https://doi.org/10.3346/jkms.2020.35.e50.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#262

Post by pure_simplicity »

DoreenMichele wrote: post #249
pure_simplicity wrote: post #247

Earlier quoted context omitted.

Thanks for the response. I'm surprised you can even get too much D with sun exposure. The thing is: I used to take vitamin D supplements fairly regularly, but now I barely take any. I will go weeks without supplementing, but when I do, I get headaches. No increased urination though, which would happen if i had excess calcium, and no nausea/vomiting. Last time, i tried 5000IU, but this came after weeks of not taking a…

I'm surprised you can even get too much D with sun exposure. I'm a special case. Trying to explain that is probably a can of worms. shouldn't give me any problems, yet it does There may be other factors there, which I could potentially speculate on. But A. It tends to be a can of worms when I start speculating like that and B. You didn't initially give enough info to really warrant such speculation. You only gave eno…

I understand. Thank you :)

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#263

Post by valarauko »

ausjke wrote: post #250
devaboone wrote: post #191

Earlier quoted context omitted.

I do see people get high calcium levels after being on this dose for years. But not always. You may be able to handle that dose. If you are getting "routine" labs done, then there is likely a calcium level in there. If your calcium is normal (under 10.0 mg/dl for adults over 40, younger adults can be a little higher), then your Vitamin D dose is ok... but I would still recommend coming down a bit on that dose. It is…

just checked my "Vitamin D, 25 OH" test: result: 13.3 ng/ml, normal range: 25.0 - 80.0 ng/ml I'm taking Vitamin D3 Max 125MCG per day, is this "overdose"? Thanks,

Since the doc hasn't replied to this question (yet), your Vit D levels are low enough to warrant supplementation. In my country it is common to supplement with 60K IU once a week, for 8 weeks, before moving to a maintenance dosage of 60k once a month. That's almost 10k IU/day during the loading phase. You're at 5k IU/ day, so should be fine. In comparison, a fair skinned person at the beach on a sunny day will make over 10k IU of D3.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#264

Post by ausjke »

valarauko wrote: post #263
ausjke wrote: post #250

Earlier quoted context omitted.

just checked my "Vitamin D, 25 OH" test: result: 13.3 ng/ml, normal range: 25.0 - 80.0 ng/ml I'm taking Vitamin D3 Max 125MCG per day, is this "overdose"? Thanks,

Since the doc hasn't replied to this question (yet), your Vit D levels are low enough to warrant supplementation. In my country it is common to supplement with 60K IU once a week, for 8 weeks, before moving to a maintenance dosage of 60k once a month. That's almost 10k IU/day during the loading phase. You're at 5k IU/ day, so should be fine. In comparison, a fair skinned person at the beach on a sunny day will make o…

Thank you!!!

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#265

Post by WhompingWindows »

neilwilson wrote: post #251
WhompingWindows wrote: post #220

If this work truly is very important, you will read about it from a reputable journal which properly vets this information. This isn't peer reviewed, it's just a website's PDF, there is no way to verify anything put onto this PDF.

This reputable enough for you? https://www.thelancet.com/journals/landia/article/PIIS2213-8...

I don't understand. The authors for your link are "Adrian R Martineau, Nita G Forouhi". The authors for the PDF of this thread are "Lorenz Borsche / Dr. Bernd Glauner".Were you trying to say others in the field are doing similar work?

My point above was that posting a PDF online is not good enough in scientific circles. The charts themselves have a number of issues which I'd ask the authors, I don't know if they've properly adjusted for the risk factors and I'm not sure I agree with their choice of denominators.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#266

Post by unstrafed »

pldr1234 wrote: post #230
unstrafed wrote: post #112

Earlier quoted context omitted.

But vitamin D almost certainly does help with certain conditions. For example, I have psoriasis and can develop awful (painful, itchy, ugly) plaques on my knees and elbows, as well as painful skin nodules on the palmar surfaces of my hands and feet and dandruff. I had seen a dermatologist who prescribed some cream that sort of worked, and she recommended I expose the surfaces to 15 mins of sunlight a day. Those kind…

As a psoriasis sufferer, I really appreciate your personal observation on this, even if it's n=1. Also curious, is it possible that the 15 mins of sunlight per day was the actual cure, rather than the supplements?

No, because I never got into a consistent habit of it and just stopped trying. Either the weather wasn't suitable or the sun was in the wrong position when I had a few minutes to do it or I'd forget. The dermatologist also wanted me to face those surfaces with the plaques/nodules toward the sun, and that was never terribly convenient when I had nodules or plaques on the bottom of my feet or my knees.

There are days where I bask in sunlight and others where I'm mostly in my hidey hole (esp. with the pandemic), so nothing too consistent. My post wasn't too clear about that, but yeah, I had stopped the dermatologist treatments (other than T-Gel shampoo) prior to the Vitamin D thing.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#267

Post by goldforever »

davidwitt415 wrote: post #153
blurbleblurble wrote: post #78

I've been very frustrated in my attempts to raise this issue with the local health department where I live. I was brushed aside, and was told "correlation does not imply causation". I doubt that the person on the phone wanted to get into a conversation about dynamical systems or nonlinear data analysis, so I didn't even go there. Instead I sent a letter full of references to published research, and citing other lette…

A simpler explanation is profit motive; it doesn't 'pay' to promote free/low cost alternatives. Most of western medicine is geared this way, imo.

EXACTLY!

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#268

Post by andy_ppp »

plus wrote: post #255
ZIMD wrote: post #232

Earlier quoted context omitted.

Fairly likely you are magnesium deficient...magnesium is a critical cofactors to vitamin D and even moderate D3 intake can trigger symptoms such as muscle cramps and heart rhythm changes. Unfortunately no easy way to accurately test a magnesium level, as it’s mostly intracellular and blood tests are pretty much useless

Possible, but I think unlikely. These days, my diet mainly consists of Soylent and Vite Ramen, which together provide me with 105% of my DRV of Magnesium in the form of Magnesium Phosphate and Magnesium Gluconate, respectively.

Not a single person knows what optimal Vitamin D or Magnesium means for the population or for you individually. So it’s very difficult assumptions here, even with testing genetics plays a huge factor.

Re: Vitamin D deficiency and Covid-19 mortality [pdf]

#269

Post by shankarganesh »

devaboone wrote: post #164
dropin685 wrote: post #144

Earlier quoted context omitted.

Here (below) is a quote from the article, on the subject of calcium. (I suppose some of us may be reluctant or unable to have calcium levels monitored. But it seems all of us should be taking vitamin K2 along with our vitamin D.) >The authors explicitly point out that each vitamin D supplementation must be accompanied by sufficient vitamin K2. This certainly prevents the rise of the calcium level in the blood, which…

Vitamin K2 does help bones absorb calcium, but it will not prevent the blood calcium level from rising if you are really taking more Vitamin D than you need. This is simply wishful thinking.

Is there a way to determine if I'm deficient in Vitamin K2. If yes, is there a way to get supplements for it?
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