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OxyContin's 12-hour problem

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Re: OxyContin's 12-hour problem

#261

Post by g00gler »

malux85 wrote: post #17
g00gler wrote: post #15

Earlier quoted context omitted.

How was going to work on the oxy? I had surgery a few months ago and stopped taking them after 2 days because I couldn't focus (or really think clearly) after taking a dose.

I was doing web development at the time, and I too found it hard to focus, especially on deeper problems - e.g. visualising deep stack traces or class hierarchies. I was able function, but it definitely required more conscious effort

Funnily enough I was trying to pick up React with my time off but I just couldn't make it do the thing. Next day, off narcotics, it was a breeze lol.

Re: OxyContin's 12-hour problem

#262

Post by Cakez0r »

siliconc0w wrote: post #163

Armchair Policy Wonk: * Make FDA approval double blind. Can't bribe who you can't see. * Before starting a study, if you want to include it with a future application you need to register it. All registered studies need to be included with an application. Can't cherry pick studies. * You may only use approved claims stated in the application in marketing or product descriptions. (which I thought was already the case)

* Make it illegal to advertise or market any drug that requires a prescription.

Re: OxyContin's 12-hour problem

#263

Post by intrasight »

55555 wrote: post #215
intrasight wrote: post #85

I had three orthopedic surgeries in 2014. Each time I got a vial of OxyContin. Figured I'd use 'em since I'm not much into pain. But the pain was not so bad. Once I tried an OxyContin to see if I could tell the difference. I could not. A colleague tells me that they have a street price of like $40/pill. So then I'm wondering how many people know that I have a thousand dollars worth of street drugs in my house. I drop…

If you are prescribed 60x80mg monthly, you could sell them for $2,400 per month quite easily. Not a bad ROI on a $20 co-pay.

Won't do that. But I would like to be able to donate them to someone for whom that copay would be burdensome. My point is that these things are VALUABLE and that violent people may want to steal them. It is another way that over-prescription can do harm.

Re: OxyContin's 12-hour problem

#264

Post by koolba »

Cakez0r wrote: post #262
siliconc0w wrote: post #163

Armchair Policy Wonk: * Make FDA approval double blind. Can't bribe who you can't see. * Before starting a study, if you want to include it with a future application you need to register it. All registered studies need to be included with an application. Can't cherry pick studies. * You may only use approved claims stated in the application in marketing or product descriptions. (which I thought was already the case)

* Make it illegal to advertise or market any drug that requires a prescription.

Hell yah. It's not a coincidence that America is the only country that allows direct to consumer advertising of medication.

Here's another one: ban all forms of compensation from drug companies to doctors. No more bribes^Wconference trips.

Re: OxyContin's 12-hour problem

#265

Post by mookerific »

koolba wrote: post #264
Cakez0r wrote: post #262

Earlier quoted context omitted.

* Make it illegal to advertise or market any drug that requires a prescription.

Hell yah. It's not a coincidence that America is the only country that allows direct to consumer advertising of medication. Here's another one: ban all forms of compensation from drug companies to doctors. No more bribes^Wconference trips.

The hilarious thing is that the US has the Foreign Corrupt Practices Act through which we can punish multinationals - usually BigPharma - for bribing doctors in other countries, where direct-to-customer advertising is prohibited.

Re: OxyContin's 12-hour problem

#266

Post by MichaelGG »

DanBC wrote: post #255
MichaelGG wrote: post #252

Earlier quoted context omitted.

Don't understate the "do not do crime". I've known addicts and the biggest damage they cause (apart from dying when they OD on unknown-quality junk) is that they become thieves and liars. No one trusts them and it tears relationships apart. Both are fixed by having more legal availability. If they were simply able to get opiate as easily as pot, then addicts for the most part would be just like potheads. Perhaps bein…

> With proper availability, opiates are very well tolerated. This just is not true. With proper availability people develop tolerance, and require higher doses. That does becomes high enough to become dangerous, and so they need to change to a different, stronger opiate. They develop a tolerance to that too. Eventually they're cycling through 2 or three different opiates (sometimes at the same time) at very high dose…

What you keep saying in these threads is that opiates aren't effective. Why then do people continue to use them? Certainly if you're in pain, you're not taking a gram of morphine-equivalent per day just because. If there are effective alternatives, why are they not used? Then with pain under control, you can slowly (over a year, say) taper down.

Re: OxyContin's 12-hour problem

#267

Post by ctingom »

Cakez0r wrote: post #262
siliconc0w wrote: post #163

Armchair Policy Wonk: * Make FDA approval double blind. Can't bribe who you can't see. * Before starting a study, if you want to include it with a future application you need to register it. All registered studies need to be included with an application. Can't cherry pick studies. * You may only use approved claims stated in the application in marketing or product descriptions. (which I thought was already the case)

* Make it illegal to advertise or market any drug that requires a prescription.

What about the first amendment?

Re: OxyContin's 12-hour problem

#268

Post by marincounty »

I can guarantee one thing. In a few months, American will be in intence pain. Good luck finding any doctor who will prescribe anything other than Ibuprofen.

I'm not going to argue. I'm not going to talk about addiction. American addiction has many heads. Yes--we can vilify a company. Yes--we can vilify painkillers.

The end result will be a nation of pain. I read the FDA prescribing recommendations. It looks like they decided protocol over a dinner meeting? The AMA followed the FDA prescribing protocol.

All I know is get ready for some misery.

Re: OxyContin's 12-hour problem

#269

Post by stryk »

cant_kant wrote: post #260

Sensible doctors do not believe drug company marketing. I get large amounts of ad-junk from drug companies that ends up unread in the bin. I refuse to meet with drug company representatives. I smile politely at them if I bump into them in the corridor and suggest that they leave their ad-junk with my secretary. My staff then file their ad-junk in the trash bin. On Friday, I had a drug company representative attempt t…

"a fixed-dose combination of oxycodone and naloxone"

That sounds similar to Suboxone, just with OxyCodone instead of Buprenorphine (i think they also make bup. minus the naloxone under the brand name Subutex). The naloxone mixture never quite made sense to me. Isn't that counter-productive? Is naloxone (aka "Narcan") not an opioid-antagonist at low doses or something?

Re: OxyContin's 12-hour problem

#270

Post by maxerickson »

stryk wrote: post #269
cant_kant wrote: post #260

Sensible doctors do not believe drug company marketing. I get large amounts of ad-junk from drug companies that ends up unread in the bin. I refuse to meet with drug company representatives. I smile politely at them if I bump into them in the corridor and suggest that they leave their ad-junk with my secretary. My staff then file their ad-junk in the trash bin. On Friday, I had a drug company representative attempt t…

"a fixed-dose combination of oxycodone and naloxone" That sounds similar to Suboxone, just with OxyCodone instead of Buprenorphine (i think they also make bup. minus the naloxone under the brand name Subutex). The naloxone mixture never quite made sense to me. Isn't that counter-productive? Is naloxone (aka "Narcan") not an opioid-antagonist at low doses or something?

The naloxone is not well absorbed when taken orally. It's in the Suboxone to deter injection.

This marketing says it's in the Targin to reduce constipation:

http://multivu.prnewswire.com/mnr/targin/36704/

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