Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

Post reply on HN
Print view View original

251–260 of 430 posts

Re: Semaglutide linked to lower predicted dementia risk

#251

Post by RajuChacha108 »

bariswheel wrote: post #48

tdlr: This is a Novo Nordisk-funded study focusing on predictive biomarkers rather than real-world dementia cases. Novo Nordisk's actual dedicated clinical trials for Alzheimer's completely failed to show that semaglutide stops cognitive decline. "A predictive biomarker is like a "check engine" light on your dashboard. It warns you that there is a risk of a future problem. In this study, the researchers only checked…

The fact that NN funded this study is very relevant but is not necessarily a negative as you make it out it to be. Perhaps that is not your intention but reading the comment made it look like that way.

1. It makes sense for companies that profit from their drugs to use their profits to also commission such studies.

2. Faking data or causing harm exposes these companies to total black swan events for which they will pay dearly so they often have incentives to release anything that might harm their patients.

Re: Semaglutide linked to lower predicted dementia risk

#252

Post by calvinmorrison »

brazukadev wrote: post #162
eastbound wrote: post #134

Earlier quoted context omitted.

You say force a diet change on a patient. OP certainly meant forcing a diet change in the input of American factories. Sugar can be found in fruits. That's the right place. If you need some, use fruits, maybe alcohol. Everything else can be slashed. No sugar in prepared meals anymore. No sugar in pasta anymore. And most of all, no sugar in water. Sugar input makes more damage than cocaine today. We can call it the Pr…

people are so addicted to sugar that you are getting downvoted and maybe even flagged. I like "The War on Sugar" idea (even tho I went out 1 hour ago to buy lots of chocolates and candies, as I'm an addict).

Closed the gyms during COVID not the McDonald's

Re: Semaglutide linked to lower predicted dementia risk

#253

Post by Suppafly »

jaggederest wrote: post #64
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

I have some individual anecdotal evidence. I spent a long time, basically a year, relatively heavy but on a very small dose of GLP drugs due to tolerability issues, and my labs improved dramatically , to a degree we redid them out of disbelief, even without weight loss. I believe one of the suspected underlying causes is reduction in fatty liver despite constant body weight and composition, and also inflammation redu…

I really wish my insurance would cover GLP-1s, because I think reduction in fatty liver and other ancillary benefits, along with the weight loss, would be medically helpful for me.

Re: Semaglutide linked to lower predicted dementia risk

#254

Post by honkycat »

SubmarineClub wrote: post #167
OptionOfT wrote: post #158

Earlier quoted context omitted.

We're too soft on companies, but equally too hard on people who have a food addiction.

[flagged]

i feel like close to half the adult population having an eating disorder has to be chocked up to a bug in the human brain at some point.

we evolved to eat caloric foods, in case of a famine that will never happen in the modern world.

I think we are too soft on people and we let dirtbags get away with way too much in the US but saying "its not that hard" is a cop out.

we get it you're a macho conservative. nobody cares.

Re: Semaglutide linked to lower predicted dementia risk

#255

Post by skirmish »

01100011 wrote: post #205
loeg wrote: post #133

Earlier quoted context omitted.

Maybe start lifting weights again? 50 isn't a death sentence; I know a lot of competitive 50s-year-olds.

I'm trying but I've got a toddler and now it seems like every joint hurts. No time to get to a gym and no room for a decent home gym. I did start to do back day again at the Y when we go on the weekend for the pool. We'll see...

A pair of adjustable dumbbells in the corner of the living room is still very doable. Lots of bodyweight exercises too you could look into.

Re: Semaglutide linked to lower predicted dementia risk

#256

Post by criddell »

RhodesianHunter wrote: post #175
dev_l1x_be wrote: post #83

Earlier quoted context omitted.

Not only that but high intakes of added sugars and fast-acting, high-glycemic carbohydrates are linked to an increased risk of cognitive decline and dementia. Excess simple sugars, particularly fructose and sucrose, promote insulin resistance, chronic inflammation, and vascular damage that impair brain function and accelerate neurodegeneration. So with other words, you diet is a major contributing factor here. The me…

Guess what category of drug reduces the intake of large amounts of sugar?

Is it the one that also reduces the intake of large amounts of protein?

Re: Semaglutide linked to lower predicted dementia risk

#257

Post by criddell »

wincy wrote: post #99
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

My wife has hardly lost any weight from Zepbound but she went from having such intense back spasms she could maybe walk a few hundred feet at a time to being able to easily handle a week at the Disney World parks on foot. Before she had to rent a motorized scooter. Absolutely life changing for her.

That's awesome!

Re: Semaglutide linked to lower predicted dementia risk

#258

Post by criddell »

emmabruns wrote: post #37
londons_explore wrote: post #23

So has anyone managed to separate the effects of semaglutide from the effects of weight loss? If this is caused by the weight loss, it is a little disappointing that public health didn't act quicker - lots of people have been overweight for a century now, so literally 10's of millions of people could have been saved from dementia had action been taken 100 years ago.

Even more so. Not absolute weight loss but the effect of loss of the systemic inflammation due to a surplus of visceral fat which has significantly more systemic effect than subcutaneous fat or other types of loss of mass.

I'm not overweight but I've been thinking about getting a low does glp-1 for the supposed inflammation improvements which could be neuroprotective. The side-effects seem minor and if it doesn't agree with me, I can just stop since I'm not using it for weight control.

I've never really read much about people using it in this way though and I'm somewhat risk averse, so it's easy for me to keep procrastinating on getting the prescription.

Re: Semaglutide linked to lower predicted dementia risk

#259

Post by swolios »

Suppafly wrote: post #253
jaggederest wrote: post #64

Earlier quoted context omitted.

I have some individual anecdotal evidence. I spent a long time, basically a year, relatively heavy but on a very small dose of GLP drugs due to tolerability issues, and my labs improved dramatically , to a degree we redid them out of disbelief, even without weight loss. I believe one of the suspected underlying causes is reduction in fatty liver despite constant body weight and composition, and also inflammation redu…

I really wish my insurance would cover GLP-1s, because I think reduction in fatty liver and other ancillary benefits, along with the weight loss, would be medically helpful for me.

[flagged]

Re: Semaglutide linked to lower predicted dementia risk

#260

Post by brians »

fcarraldo wrote: post #237
SoftTalker wrote: post #44

Earlier quoted context omitted.

With all the research into dementia and its causes, if there was a simple strong link to overweight I can't imagine that would not stand out in the data and be well known by now. Edit: although, there are well-known links between overweight and a lot of negative outcomes, and yet people are still too fat.

Nearly 75% of Americans are overweight. (over 30% 'overweight', over 40% 'obese'). Obviously, 75% of Americans do not develop dementia. Do more who are overweight develop dementia than those who are not? Well...it's hard to say when 3/4ths of the population is overweight.

Actually that makes it really easy to tell. If one side were very rare maybe we’d miss a subtle effect. But at 3:1 we should see plenty!
Post reply on HN