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Habitual coffee intake shapes the microbiome, modifies physiology and cognition

nature.com

251–260 of 281 posts

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#251
I stopped drinking coffee for four or five years. I drank a lot before. You do realise that it has a strong psychoactive effect, at least it did for me.

I still don't drink coffee, but I started experimenting with paraxanthine and I absolutely love it (paraxanthine is the primary metabolite of caffeine and is also a stimulant). I feel like it gives me most of the benefit of caffeine with very few downsides (no jitters, no crash, exits your system faster).

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#252

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Quitting caffeine after decades of use was a bit of a mixed bag for me in the short term, but positive in the long term. Going caffeine-free made it much easier to lose weight as I have far less cravings for high carbs and sugar now, presumably this is related to the impulsivity impact talked about in the paper. Going caffeine-free also made me very depressed for a while with severe anhedonia, this lasted way longer…

> Going caffeine-free made it much easier to lose weight as I have far less cravings That's surprising to me. In my case one of the reasons I discontinued it (emotional effects aside) was mild but consistent weight loss. The stimulant part of the effect seems to suppress my appetite quite effectively although at least part of that is likely indirect due to sustained task focus leading me to skip meals.

A lot of people and research focus on coffee suppressing appetite, which is downstream to the cortisol-raising effects of fight-and-flight response which raise blood sugar among a myriad other things. What they forget is that elevated blood sugar and cortisol eventually results in lower blood sugar than baseline — which is when the hunger strikes.

So yes, coffee is an appetite suppressant, but 6-8 hours later your appetite rebounds. Many people don't feel this effect simply because they have frequent-enough meals and/or coffees to stay ahead of the blood sugar crash. If you get into intermittent fasting, it's pretty easy to notice. In my quest to fix my metabolism, I am constantly aware that my morning cup of coffee is the biggest reasons why I get ravenous around 5pm.

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#253

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Working with a psychiatrist, I take half the minimum therapeutic dose of generic Adderall as-needed. Caffeine makes me feel like I'm overclocked, but Adderall lets me run tasks async. The latter is so much more preferable for dealing with the demands of life. Medicate at 4pm, then I know I can effortlessly interleave chores, family time, social obligations, and my own creative pursuits. Otherwise I'd spend my evening…

That's pretty interesting, thank you. To me Adderall is a bridge too far though. I don't want to truly medicate (though I guess we can always argue semantics i.e. is getting coffee everyday not like medication?). I just need something like the Americano every now and then really. I agree on vigorous exercise completely. My last two jobs have been (well, the current one still is) hugely demanding and that led to me dr…

I used to be prescribed lisdexamfetamine for ADHD and after 3 years it did feel "a bridge too far for me" as well.

My stimulant of choice now is low-dose nicotine patches which I feel is extremely underrated, and demonised because of the effects of smoking and vaping. Mind you: I am an ex-smoker and I am quite aware of how strong the addiction can be, yet pure nicotine is the most mellow stimulant there is.

It's been 2 years now since I replaced my ADHD medication with nicotine and I haven't felt the need to increase the dosage. It's cheaper, lasts MUCH longer, doesn't cause anxiety and it doesn't push you around like amphetamine.

YMMV.

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#254
post #85

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I don't have the same experience, and I drink one cup of coffee (270 ml) almost every day. No agitation, no impulsiveness. I can drink coffee in late evening (let's say 8 pm) and sleep well. I guess I'm trying to say that we should not project our own experience on others, everyone is different.

In my experience, this is common among people with ADHD (myself, friends with ADHD, family with ADHD, psychologist’s patients anecdotal evidence). YMMV

It's not, really. Coffee is an anxiety and insomnia machine for me, while nothing made me as calm as amphetamine (even my heart rate was lower).

I do have a professional diagnosis for ADHD.

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#255

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I like this worldview. Prior to coffee, Europe was in the grip of the beer dwarves. Coffee demons took over and invented nationalism, capitalism and Keynesian economics.

Putting Keynesian economics next to nationalism on the evil list was so funny, I almost spit out my coffee.

Is it? Keynesian economics created the economic framework to finance World Wars.

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#256

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> a normal mug of ~500ml woa where is half a liter of coffee a "normal" portion?

500mL is a pretty typical size for a travel mug/tumblr. I'd consider that two or three servings though.

500mL of Americano (diluted coffee) is not 500mL of espresso. I challenge you to drink half a litre of espresso in one sitting.

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#257
post #141

It's always amusing to read the self-narratives of a bunch of unacknowledged drug addicts when links like this get posted.

"To prove I wasn't addicted I stopped for a week. I felt depressed and tired. I'm back to my 3 cups of coffee a day as it cures my depression."

— every HN thread about coffee

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#258
post #238

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That doesn't make sense, as my 1 cup takes 10g and 3 cup takes 30g.

Is yours a Bialetti? Mine's the "4 cup" stainless steel Venus, so I think it's probably like a "3 cup" Moka Express: https://www.reddit.com/r/mokapot/comments/1p61tgb/how_much_c...

Yes bialetti original. Sounds like the venus is the difference.

Ps Check out moka pot voodoo on YouTube, if you haven't already. I almost never make a bad brew now (except for literally just now, but was with a new bean, roasted darker than usual. Will grind finer next time).

Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#259
post #148

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Possibly AI, possibly younger folks (18-24). “Mental health incident” is only one step removed from algospeak like “unalived”, “seggs”, and “neurospicy”. A detached, memetic phrase that has been implanted into the lexicon by a toxic brew of algorithmic social media moderation and heavy exposure to LLM conversational patterns.

Or maybe just because language patterns change over time. You need to be hep to the new jive, daddy-o.

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Re: Habitual coffee intake shapes the microbiome, modifies physiology and cognition

#260

Earlier quoted context omitted.

Especially if you like Americanos, chances are you'll be happier with filter coffee from good beans, rather than spending it in an espresso machine. Get an Aeropress, or Hario Switch, or Clever dripper. A kettle and some filters. For beans buy from roasters that do light/meduim roasts, and print a recent roasting date on the package/website. The only expensive item should be a grinder, look at 1zpresso Q/Air/X or Kin…

Not gonna lie, this sounds like way too much work. What I am mostly looking for is some sort of an easy access to a diluted coffee like the Americano, really. I am OK with buying 1-2kg of beans because I am fairly sure that's going to last me 3-6 months. Cleaning the machine I've done in offices -- 3 minute job. But any more commitment just sounds tiring. I am not a coffee connoisseur by any stretch of the imaginatio…

I finally gave in and got a breville bambino plus and I have no regrets. It was $400 on sale, produces quite decent espresso, foams milk well, has been very reliable, and doesn't heat up the kitchen - I held off getting an espresso machine for years because the instant heat ones always seemed to suck. This one doesn't. I mostly drink Americanos and straight espressos, my wife drinks lattes, everybody is happy.

But I have to agree with others: for my diluted espresso desires, I used (and still have) an Aeropress for years and it's simply fantastic. Low cost, almost zero maintenance, good results. Very similar output to an americano though lower on crema.

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