Ozempic shows anti-aging effects in trial • Hacker News Board

Re: Ozempic shows anti-aging effects in trial

#251

Post by Der_Einzige » Wed, Aug 06, 2025, 3:47 AM UTC

jbentley1 wrote: post #16

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Naturally skinny people hate Ozempic for the same reason I know many talented engineers who hate AI coding.

Was waiting to see this comparison. Glad to see that meritocracy is becoming the pejorative it was always meant to be. Meritocrats are unironically bigots.

Re: Ozempic shows anti-aging effects in trial

#252

Post by Der_Einzige » Wed, Aug 06, 2025, 3:49 AM UTC

neves wrote: post #43

Be very cautious with these miracle drug headlines. There's a strong financial incentive to highlight only the good news. My mother, a healthy and active 87-year-old, started taking Ozempic because she was overweight and her doctor was impressed by the drug’s supposed miracles. She ended up suffering from severe intestinal motility issues, went through a lot of pain, and had to be admitted to the ICU. The long-term s…

Maybe don’t give them to grandma? Idk man but at 87 anything that happens might as well have been the grim reaper deciding it was their time.

Re: Ozempic shows anti-aging effects in trial

#253

Post by nradov » Wed, Aug 06, 2025, 3:50 AM UTC

42772827 wrote: post #235

throwawaylaptop wrote: post #142

Earlier quoted context omitted.

I helped my dad lose 50 lbs by finally, after 10 years, getting him to give up bread, sugar, potatoes. It took buying him 2 months of a bluetooth glucose monitor. Once he saw what certain foods do, he believed me finally. At 65 years old, healthier than I remember since he was 40 and I was a teen. It doesn't require some weird injection.

He could have lost all that weight and still had bread, sugar, and potatoes but instead he gave up what he clearly enjoyed. Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad.

I don't understand. What's sad about giving up junk carbs?

Re: Ozempic shows anti-aging effects in trial

#254

Post by meroes » Wed, Aug 06, 2025, 3:50 AM UTC

throwawaylaptop wrote: post #194

leidenfrost wrote: post #182

Earlier quoted context omitted.

Insulin control is about managing hunger more than a direct cause for weight. You don't even need to do keto or wacky "just meat" diets to handle insulin. Protein consumption prevents insulin spikes for around 1-2 hours after eating. Also, proteins and fats slow down digestion. Turns out, the good old Mediterranean diet is spot-on for a healthy lifestyle.

? Insulin is not about management of hunger. I think you got your hormones mixed up. But yes, meat and vegetables is basically what I'd recommend. Never pasta or bread or sugar unless you need help gaining weight.

Meat and vegetables would make me sedentary from having inadequate glycogen for physical work and exercise.

How about: some pasta and bread to enable physical exertion.

Re: Ozempic shows anti-aging effects in trial

#255

Post by nradov » Wed, Aug 06, 2025, 3:50 AM UTC

42772827 wrote: post #241

throwawaylaptop wrote: post #238

Earlier quoted context omitted.

Believe me, cutting out bread and sugar completely is 10x easier than some kind of lifelong moderation for a person that has struggled for it already for most of his life. And he is extremely happy with his new sugar and bread free life of increased mobility, less pain, and much lower blood pressure. At 64, he's learning how to ride a dirtbike and doing pretty well at it.

The choice is no longer between "cutting out bread and sugar completely" and "some kind of lifelong moderation for a person that has struggled." The choice is now between "cutting out bread and sugar completely" and "removing the struggle to moderate bread and sugar." You're clearly an advocate for your father making healthy choices. So why would you advocate against the use of a drug that makes that easier?

Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.

Re: Ozempic shows anti-aging effects in trial

#256

Post by 42772827 » Wed, Aug 06, 2025, 3:55 AM UTC

nradov wrote: post #253

42772827 wrote: post #235

Earlier quoted context omitted.

He could have lost all that weight and still had bread, sugar, and potatoes but instead he gave up what he clearly enjoyed. Now he gets to live out the rest of his life fighting cravings, telling himself he's not allowed to enjoy food. How utterly sad.

I don't understand. What's sad about giving up junk carbs?

Bread, sugar and potatoes exist on a spectrum from highly processed/refined (truly problematic) to minimally processed whole food versions (nutritionally valuable). There's no reason to give up minimally processed whole food versions of these.

Re: Ozempic shows anti-aging effects in trial

#257

Post by nwienert » Wed, Aug 06, 2025, 3:55 AM UTC

genewitch wrote: post #245

smt88 wrote: post #152

Earlier quoted context omitted.

"GLP-1s are beneficial for many conditions downstream of liver dysfunction and metabolic disease" is a much milder claim than "cure-all".

also in the news in the last couple months was "promising for breast cancer" and another cancer (can't remember, don't care), and depression as well as some other mental health disorder. If you would like to give me money i would be happy to do the research on what claims have been published about GLP-1 inhibitors since they became prescribed off-label. I assure you it's more than "many conditions downstream of [...]…

As someone who saw miraculous cessation of lifelong immune issues on it, saw another friends dramatically improved allergy symptoms, another lifelong smoker finally quit, and other friends generally get in great shape, I actually do believe it’s uniquely good. If even half of the seeming benefits it seems to be showing in early stages right now turn out to be true, it is.

Re: Ozempic shows anti-aging effects in trial

#258

Post by 42772827 » Wed, Aug 06, 2025, 3:55 AM UTC

nradov wrote: post #255

42772827 wrote: post #241

Earlier quoted context omitted.

The choice is no longer between "cutting out bread and sugar completely" and "some kind of lifelong moderation for a person that has struggled." The choice is now between "cutting out bread and sugar completely" and "removing the struggle to moderate bread and sugar." You're clearly an advocate for your father making healthy choices. So why would you advocate against the use of a drug that makes that easier?

Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.

If changing habits were much easier, then people wouldn't be using the drug to make it easier change their habits. They would just do it.

Re: Ozempic shows anti-aging effects in trial

#259

Post by koolba » Wed, Aug 06, 2025, 4:01 AM UTC

XorNot wrote: post #197

const_cast wrote: post #103

Earlier quoted context omitted.

At a low level, yes, corn, but at a high level: more consumption = more money. Everyone benefits from you being fat. Your doctors, your car manufacturer, food manufacturers, everyone. Except maybe health insurance. But they're not hurt too too much.

There is no doctor on Earth who goes to work and thinks "thank god for fat people or I wouldn't have a business". There's plenty of doctors and surgeons who wish there were less fat people, because they enormously complicate doing surgery on and managing in hospitals.

> There is no doctor on Earth who goes to work and thinks "thank god for fat people or I wouldn't have a business".

What about everybody that works in liposuction?

Re: Ozempic shows anti-aging effects in trial

#260

Post by jonny_eh » Wed, Aug 06, 2025, 4:05 AM UTC

some_random wrote: post #15

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

It’s the same people that hate vaccines, fluoride, and sugar substitutes. They feel like those interventions are too good to be true.