So if you send a picture to a Signal user, it's retrieved via cloudflare, and cached in a data center near that user; now you can look up the cache status and find the data center used. I'd say "deanonymization" is stretching it, unless the user is in the middle of nowhere (no other users near the data center). But interesting writeup anyway.
For example, imagine someone suspected of sharing sensitive information with a journalist. They might have a short list of suspects, and use this technique to confirm which one it is. They might identify which journalist it is - maybe only a limited number cover this beat.