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Psilocybin desynchronizes the human brain

nature.com

251–260 of 276 posts

Re: Psilocybin desynchronizes the human brain

#251

I can't think of anything in the world I would enjoy doing less than completing "a simple auditory–visual matching task" while in an MRI scanner on shrooms.

The set and settings researchers typically use for usual psych studies are going to bias psychedelic results so much. Think that building you hated in undergrad's crusty unlit cinderblock basement with no windows but coated in cameras and microphones. Its so dystopian, you are literally a caged rat. I don't think you can perform this research in good faith without having experienced a proper trip yourself. It's just…

Very good points. My understanding from talking to a research assistant, the research groups doing lsd/mdma/psilocybin studies based in Basel and Zürich are led by drug experienced researchers.

Re: Psilocybin desynchronizes the human brain

#252
post #180

Earlier quoted context omitted.

Science is all about removing feelings, accepting that it isn’t possible to not feel and channel that into constantly doubting. Feeling doubtful is fundamentally different than feeling enlightened.

Are scientists a part of science?

Not a philosopher, but IMHO yes. But so is the scientific method.

Re: Psilocybin desynchronizes the human brain

#253

Earlier quoted context omitted.

> Before using psychedelics, it's important to anchor ourselves by questioning the difference between knowing something and feeling like we know something. The inverse seems more prudent to me, since mostly all global decisions get made when not on psychedelics, and we arguably have a severe lack of truly novel, out of the box ideas...who knows, maybe something useful for addressing climate change, polarization, etc…

Idea generation from psychedelics is okay, but we should avoid thinking we've received a divine revelation of unquestionable truth because it felt true.

This should also apply to the same during normal consciousness, but for some reason that state is privileged, beyond absolute questioning or suspicion. It's quite a neat trick.

Re: Psilocybin desynchronizes the human brain

#254
post #252

Earlier quoted context omitted.

Are scientists a part of science?

Not a philosopher, but IMHO yes. But so is the scientific method.

Do you believe it is possible to know what all scientists are up to, or how "good" science is on an absolute scale?

Re: Psilocybin desynchronizes the human brain

#255
post #126

Earlier quoted context omitted.

Similar thing. My good friend and early college roommate took his own life with a gun after having a bad trip. I wasn’t there for it, but the way he described it he felt ridiculed and deserted by his old high school friends during the trip. He was left alone to deal with these feelings. His mood post trip became increasingly abysmal. He became highly paranoid, and started questioning the loyalty of the people close t…

Access to weapons is also a problem. That could have been a transient event he would have recovered from.

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Re: Psilocybin desynchronizes the human brain

#257

Earlier quoted context omitted.

I’ll back you up but having done shrooms about a dozen times decades ago, you’re really missing out on a truly out of this world experience.

Betting your life to get a hallucination is not worth it even at 1:10000 odds. Guess what - you're missing out on a fentanyl high, so awesome that people sell all they have to get more!

Mushrooms have saved more people than they have harmed, I guarantee you. I believe you have a very warped or misguided understanding of what exactly psilocybin is and I'd encourage you to learn.

Re: Psilocybin desynchronizes the human brain

#258
post #204

Earlier quoted context omitted.

That sounds like a relatively common Covid side effect.

[flagged]

It's not a common side effect of the vaccine though. It definitely is a relatively common side effect of actually catching the disease itself though.

Re: Psilocybin desynchronizes the human brain

#259
post #204

Earlier quoted context omitted.

[flagged]

The amount of antivax shit that floats around in a supposedly well informed community such as this is nauseating. Makes me lose my faith in humanity a bit every time I read it.

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Re: Psilocybin desynchronizes the human brain

#260

Earlier quoted context omitted.

The set and settings researchers typically use for usual psych studies are going to bias psychedelic results so much. Think that building you hated in undergrad's crusty unlit cinderblock basement with no windows but coated in cameras and microphones. Its so dystopian, you are literally a caged rat. I don't think you can perform this research in good faith without having experienced a proper trip yourself. It's just…

I've never had a good trip indoors. My brain has a knack for staying grounded by familiar settings, so I hardly even experience the trip. Put me outdoors in the dark and my brain can be stimulated by natural sounds which are not nearly as predictable as those I find indoors. I think it has to do with processing stimuli that I can't instantly attribute to something I know very well. I am also normally hypervigilant, w…

SAME!

I'm often just bored. and on shrooms. Which is fine, just a bit unpleasant.

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