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Brain waves appear to wash out waste during sleep in mice

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Re: Brain waves appear to wash out waste during sleep in mice

#251

Post by robg »

moffkalast wrote: post #124
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

I wonder if eventually once this is more thoroughly researched there could be a way to induce constant cleaning instead of having to do it while unconscious at night? Or at least reduce the hours required. If we could solve this we could just stay awake perpetually and instantly gain a 30% longer lifespan as it were.

There already is constant cleaning, the brain just can’t seem to keep up. Sleep is more efficient at clearance. People are working on making sleep more efficient. As you can imagine, military leading here.

Re: Brain waves appear to wash out waste during sleep in mice

#252

Post by alfor »

magicalhippo wrote: post #155
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

My suggestion is to try a religious conversion to christianity. I know it sound weird, but we all live in a story and she relive the same story over and over in her dreams and in real life.

Christianity will help her make sense of what happenend and will help her get over it. She will have a place to put evil and a place to put good and she will be slowly be able to fix the direction of her mind.

She can search for scripture that speak around what happened to her and see what she can do about it. She will ask for help to go past her trauma.

I tought all my life that it was supersitious nonsense (scientific atheist) but I found out that I was wrong. We have no choice, we are religious by nature. Without a solid faith we are free floating, anxious, depressed, confused and stuck in loops.

Re: Brain waves appear to wash out waste during sleep in mice

#253

Post by thejazzman »

magicalhippo wrote: post #176
canadiantim wrote: post #170

Earlier quoted context omitted.

She should try ketamine. Sounds like it’s exactly what you say, past trauma, that’s holding her back from a good nights sleep. Ketamine has done wonders for someone I love and I would wholeheartedly recommend it. The person in my life who benefited greatly from it only needed one weekend (2 relatively low to medium dose sessions of ketamine) and she was cured of her ptsd. Also strongly recommend weighted blankets, es…

We've investigated ketamine treatment, which does indeed sound very interesting. However very few clinics here that offer it, though it seems to have improved recently. Definitely will follow up on this.

Look up Spravato. They are also online doctors. And there are similar DIY methods you can grow at home if you're ambitious.

No promises it'll help, though. But hope feels good by itself sometimes.

Re: Brain waves appear to wash out waste during sleep in mice

#254

Post by _y5hn »

hombre_fatal wrote: post #160
ArthurAardvark wrote: post #55

Earlier quoted context omitted.

It's hilarious to me that these practices are laughed off, trivialized through memes and hyper-objectivity (science can't evaluate their value in a practical manner -> "Lulz hippie-dippie nonsense for ditzy/ungrounded women!!!!" -- Western dolt). Its insane considering their benefits...that are of course tragically perfect for those who would never participate Of course that's a huge generality, I'd say it may be 1 o…

It's dismissed like any other woo woo bullshit: strong claims, no evidence. Where's the evidence that yoga and meditation accomplish the effects of sleep and how strong is it?

There are studies on this, and I see they've been updated a bit. It doesn't seem to replace sleep due to Delta-waves during deep sleep, but can be used over time to maybe reduce the need for sleep. Enough sleep is of course important for clarity of mind and for releasing toxins and stress. In the West we often suffer from chronic sleep-deprivation, so meditation may help in that as well as ensuring enough rest in order to recuperate.

https://www.artofliving.org/us-en/meditation/sleep/meditatio...

You don't really need studies for this when you can have experiential evidence through own practices, which is much more important for an individual than external studies.

Re: Brain waves appear to wash out waste during sleep in mice

#255

Post by _yb2s »

Aeolun wrote: post #138
_yb2s wrote: post #106

Earlier quoted context omitted.

All NIH funded research is freely open access by law. In this case it seems the authors didn’t pay the (crazy expensive) Nature open access fee. They will have to upload a free PDF to PubMed manually, but have up to a year to do so, and don’t seem to have done it yet.

Is Nature’s open access fee really that crazy? Last time I checked it was a few thousand dollars. And it’s paid once, to make the whole thing open perpetually. It certainly seems better than having the people interested in reading it pay $30-40 each. Of course, this is also based on the few times I’ve heard researchers talk about the ways they could spend their grant money. $2k to Nature sounds like a great deal by c…

It’s over $12k, which seems insane, and is 5-10x what other journals charge.

These journals are a racket… volunteer editors, volunteer reviewers, and thousands for what amounts to PDF hosting… which they also charge every school and library in the world on the other end.

Re: Brain waves appear to wash out waste during sleep in mice

#256

Post by danielscrubs »

magicalhippo wrote: post #155
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

Sounds too simple but high doses of vitamin C before sleep removed all of my stress induced nightmares.

Re: Brain waves appear to wash out waste during sleep in mice

#258

Post by smolder »

ineedaj0b wrote: post #72
smolder wrote: post #69

Earlier quoted context omitted.

Huh? It cleans the brain? Care to elaborate or provide a source?

It certainly keeps you alert. Removes the ‘sleepy/tired’ feeling. But it might not clean the brain. It might change the comfort level of ‘clean’ you brain finds acceptable before commanding the janitor out of his closet.

I suspect quite the opposite: modafanil is going to interrupt your sleep such that your body doesn't dispose of waste from the brain as well.

Re: Brain waves appear to wash out waste during sleep in mice

#259

Post by michaelkeenan »

magicalhippo wrote: post #155
robg wrote: post #87

If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

I know you've probably already tried lots of things, and you're also inundated with ideas from others, but:

Here's a psychiatrist's guide to solving insomnia: https://lorienpsych.com/2021/01/02/insomnia/

And here's a psychiatrist's guide to solving nightmares: https://www.astralcodexten.com/p/peer-review-nightmares

Prazosin is the standard drug for PTSD-related nightmares: https://en.wikipedia.org/wiki/Prazosin

Re: Brain waves appear to wash out waste during sleep in mice

#260

Post by infradig »

michaelkeenan wrote: post #259
magicalhippo wrote: post #155

Earlier quoted context omitted.

It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…

I know you've probably already tried lots of things, and you're also inundated with ideas from others, but: Here's a psychiatrist's guide to solving insomnia: https://lorienpsych.com/2021/01/02/insomnia/ And here's a psychiatrist's guide to solving nightmares: https://www.astralcodexten.com/p/peer-review-nightmares Prazosin is the standard drug for PTSD-related nightmares: https://en.wikipedia.org/wiki/Prazosin

I'd be careful with Prazosin. Awful few weeks of violent and suicidal thoughts before it mellowed out into an emotionally zombified plateau, then I quit it. Cured my PTSD though.
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