Earlier quoted context omitted.
The middle 2 links are by solo developers - I wouldn't call those significant production systems. Generally tools like React are helpful for managing complexity across large systems where nobody understands the whole app and layers of of features, bug fixes and optimizations have been baked in over the years and nobody understands the whole app anymore
The reason "nobody understands the app anymore" is due to the complexity of React and not the application. HTMX tries to reduce the complexity.
By the time you create the correct abstractions, customer needs and the market will have changed and thus your abstractions are now incorrect