My mind is blown that Excel's usability is so bad that the representation of the human genome itself has to adapt around it's undesired behaviour. As in, the history of genetics research is now irreversibly linked with the shortcomings of this one software product, which just happens to be incapable of describing the genetics of the organisms that created it.
Excels usability isn't bad though. Which is why everyone uses it. It falls down in this (and lots of other cases) but if you want to see what good usability looks like, look at what people use.
It's a terrible app but Microsoft managed to shove it everywhere in education. Same for Words.
Unfortunately Libre Office and co tried to reproduce the terrible UX of both software, while coming up with inferior functionalities because they had to try to maximise compatibility with these MS tools, time not spent on providing actual useful stuff.
Access is a bit better and I wish more non programmers learned basic SQL instead of Excel.