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Peptides: where to begin?

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Re: Peptides: where to begin?

#241

Post by throwaway2037 »

steveBK123 wrote: post #238

I think we are sort of in the worst of both worlds right now re: medicines/supplements/gray market. FDA approval is expensive slow process. Doctors train for a long time and then work 40+ years entire careers, some without a ton of continuing education. But then we have an entire gray market because enough legal and practical loopholes to drive a freight train through, such that people are self medicating with dubiou…

    > some without a ton of continuing education.
Where did you get this idea? I did a simple, five second Google search and learned that on average, US doctors are required to complete about 50 hours of continuing education for each one- to two-year recert cycle. (On HN, I also hear similar complaints about public school teachers. It isn't true. Public school teachers are required to do similar continuing education.)

Re: Peptides: where to begin?

#242

Post by throwaway2037 »

staticassertion wrote: post #223
flexagoon wrote: post #219

Earlier quoted context omitted.

For the first one, I assume you mean a systematic review, not a peer review? I guess you're talking about this one: https://pmc.ncbi.nlm.nih.gov/articles/PMC10180699/ It has a Mechanism section which explains that when collagen is digested, one of the products of that is Gly-Pro-Hyp, which is what has the effects. I don't think that conflicts anything in this post?

I assume they're referring to the brief bit in the post that indicates that oral ingestion leads to a breakdown that makes oral supplements of amino acids pointless. They say it very briefly and they don't really outright assert it, it's just a sort of implied aside.

Here is the exact quote:

    > You’re not going to be taking these things orally... These mail-order peptides are injectable items.
Every single YouTube video and blog post I have read about peptites is exclusively about injectable supplements.

Re: Peptides: where to begin?

#243

Post by dotancohen »

Zetaphor wrote: post #127
GenerWork wrote: post #10

Earlier quoted context omitted.

To your first point, if you know where to look, you can get tens of vials of GLP-1s that have much higher dosing per vial for cheaper than you can get a third of the amount on the grey market. A lot of these sites even have purity testing to soothe consumers worries that they're getting garbage. For your third point, you have the FDA limiting HGH, yet you can buy the growth horomone releasing factor peptides (tesamor…

Many of us would appreciate if you could share one of those reputable vendors with such cheap prices

My Gmail username is the same as my HN username, for anybody who needs a reliable source with lab test results.

Re: Peptides: where to begin?

#245

Post by ifyoubuildit »

picafrost wrote: post #187

[flagged]

"Antivaxxer*" here. I'm not injecting peptides for a similar reason - I'm not convinced the cost/benefit works out. That said, the issue for many is autonomy - if you want to put novel stuff in your body, go ahead. As long as you don't try to compel me to do it.

* Not if we're actually in literate company, but that seemed to be the common consensus after I skipped the jab, having recovered from covid right before the shots became available. Nevermind that my doctor was on board and I've had all the other ones (minus the flu shot). I was still a selfish grandma killing Republican who probably voted for trump to the commentariat.

Re: Peptides: where to begin?

#246

Post by throwaway27448 »

steveBK123 wrote: post #233
throwaway27448 wrote: post #210

Earlier quoted context omitted.

In my experience, everyone who defends tipping culture is defending not paying the tip. I don't buy this idea that someone likes tipping culture and still pays it. After all, you're free to tip anyone you want regardless of culture.

The problem is it is so ingrained in US culture that switching to tip-free has generally failed where tried, even in pro-labor lefty hoods in blue cities. Numerous restaurants in NYC tried and flipped back over the last 10 years. Restauranteurs reported illogical / innumerate behavior where sales went down when they switched to untipped higher prices. https://www.eater.com/21398973/restaurant-no-tipping-movemen... Th…

Well sure, it has to be mandated through law or underpaying workers will inevitably outcompete those that pay workers. I don't think that's an argument that anyone likes tipping culture (except wait staff in bougie cities).

Re: Peptides: where to begin?

#247

Post by throwaway2037 »

tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

This is crazy. You lost 28 lbs (15% of your body weight) in 10 weeks. Why did your doctor to allow you to continue? By any common sense, that is an unhealthy pace to lose body weight.

Re: Peptides: where to begin?

#248

Post by throwaway2037 »

staticassertion wrote: post #207
tbojanin wrote: post #21

I tried retatrutide for 10 weeks, here are my results: Before: 5'7, ~182lb Bench 1rm: 315 Squat: 5x10 225 Deadlift: 5x5 315 After: same height lol, 154lb Bench 1rm: 285 Squat: 5x10 205 Deadlift: 5x5 275 Suffered some anhedonia towards the end but that went away ~1wk after stopping. Overall pretty good, not any side effects. Definitely fixed my food craving problem. I didn't have a high intake of protein during the 10…

Even if you hadn't lost any muscle mass, zero chance you're going to see the same exercise performance on a calorie deficit.

This is untrue. There are 100s of YouTube videos of amateur body builders preparing for a show. They are able to maintain their muscle mass while in a calorie deficit. Yes, it is insanely hard, but it can be done.

Re: Peptides: where to begin?

#249

Post by H8crilA »

picafrost wrote: post #187

[flagged]

A lot of these peptides are designed to optimize bodies. And a lot of these people suffer from OCD - often a similar type to anorexia. No, it is not normal to intrusively think about your body every few minutes, most people that you see around you do not think about their bodies more than maybe once a day, when they look in the mirror after a shower. And maybe not even that.
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