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Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
241–250 of 393 posts
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#242Earlier quoted context omitted.
The evolution of who gets HPV vaccines is really interesting. At first it was young women, as vaccinating young men had a very marginal decrease in cervical cancer rates via indirect protection (which itself is a function of how many young women are vaccinated). Then as HPV infection was linked to more cancers, vaccinating young men crossed the cost-effectiveness thresholds many governments use. Vaccinating older pop…
it's not just the cost of the vaccine roll-out though, you need test on your target demo and since these are healthy people the bar is very high. If the demographic (like males over 45) shows very little involvement in the infection vectors then testing might fail the cost-effectiveness, not the delivery of the vaccine.
Indeed. Generally for HPV, there were modeling studies showing this was probably a good idea before trials started.
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#243Wasn’t this also the same conclusion for Australia? Cervical cancer plummeted to record rates. Men should still get it so they don’t effect their partners and HPV causes all sort of cancer too.
Yes, Michael Douglas had a throat cancer he said was from "oral sex" meaning HPV infection, and I remember social media berating him for saying that as if it were impossible, but it really is.
Random anecdote: with whole genome sequencing, which is fairly common among the rich with cancer, you can sometimes find the exact cancer driving genes that the HPV has amplified. I remember looking at one case where the HER2 gene was amplified with many copies, and you could see it attached to chunks of HPV genome. Fortunately there's now many drugs that specifically target amplified HER2, originally developed only for breast cancer, where there are diagnostic test to find the subset of breast cancers with the amplification.
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#244the
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#245Earlier quoted context omitted.
There are multiple strains of HPV and most people haven't been infected with all of the strains. from https://www.health.harvard.edu/diseases-and-conditions/by_th...
Does the vaccine work against all strains ?
It has only been targeted against the strains known to cause cancer. I haven't looked but I would guess getting all strains would have been a greater challenge, and would not have greatly increased uptake of the vaccine. The false perception that it's a vaccine that will encourages unprotected sex has already greatly hindered adoption in the US.
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#246If you're living in the US: please consider getting the vaccine, ragardless of your age. It was covered by my (rather shitty) health insurance. It consists of just 2 (EDIT: 3 for adults!) doses. It is recommended for both Males and Females.
I'm male and read about this exposure vector back in 2012 when it was only rolled out to 12 year old girls, with a further guideline that nobody over 26 should take it. this was pre- antivaxxer anxiety, and just run of the mill 'is the government condoning sex' anxiety, and it was controversial for that reason alone the issue was that if you've been exposed already then the vaccine doesn't work. they had a test for w…
"this was pre- antivaxxer anxiety" - It was really, really not.
Another thing to keep in mind was that the initial trials were only using cervical cancer endpoints - the association between HOV infection and cervical cancer is really strong. At that time, vaccinating boys provided only indirect protection (you couldn't infect a female partner), rather than direct protection (you won't be infected) in the context of cervical cancer.
Women prior to sexual debut were the biggest "bang for the buck" and the obvious first recommendation target.
Researchers both at universities and in private industry then started working on other populations based on alternative endpoints.
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#247Earlier quoted context omitted.
There are multiple strains of HPV and most people haven't been infected with all of the strains. from https://www.health.harvard.edu/diseases-and-conditions/by_th...
Does the vaccine work against all strains ?
No, it's targeted against those most associated with cancer.
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#248Denmark is in a chronic baby shortage [1] and people in Western democracies are having less sex generally [2]. So, yay, less HPV. Go get vaccinated [3]. Unfortunately, there are some pretty significant (and sad, yes, sad) confounders.
[1] https://www.sdu.dk/en/nyheder/faldende-fertilitet
[2] https://www.google.com/search?q=western+democracies+decreasi...
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#249Earlier quoted context omitted.
I'm sorry, but you sound like the people who try to get me take ivermectine for Covid. "just get it off label" or "tell the doctor you just got back from pauea new guinea and saw worms in your stool." I know you are very well intentioned, but American's actually have very good doctors.
This is very different from recommending horse dewormer; if you can't tell the difference, I'm sorry.
Ivermectin is also used by dermatologists to fight face parasites that cause bad acne.
Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out
#250Earlier quoted context omitted.
Oh wow how the conspiracy theories change. There used to be fears of "death panels" controlling access to medical care when Clinton tried to propose universal health care. The CDC and FDA are about safety, not cost management. And they get significant complaints about how much they regulate pharma and are impediments to pharma for that! Now the conspiracy theorists of the other side seem to be having their day in the…
This isn't a conspiracy theory - I worked on projects around that during graduate school, and talked to my colleagues who worked on them. Cost-effectiveness thresholds are a consideration that goes into how widely a vaccine will be rolled out, etc. That was, for example, why boys were originally not part of the recommendation for the HPV vaccine. It would double to cost, while doing very little to prevent cervical ca…
Cost considerations would be more from the CDC's Advisory Committee on Immunization Practices, not the mentioned above United States Preventive Services Task Force. (Oh, and I see that another comment parallel to mine up there now mentions ACIP too...)
In any case, somebody thinking that evaluating safety and efficacy aside from cost considerations means that there's collusion with pharmaceutical companies would be a conspiracy theory.