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Weight-loss drug found to shrink muscle in mice, human cells

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Re: Weight-loss drug found to shrink muscle in mice, human cells

#241

Post by adgjlsfhk1 »

cyberax wrote: post #232
bluSCALE4 wrote: post #222

Earlier quoted context omitted.

Most kill you. If I didn't misread articles on ozempic, they can cause digestive problems where food rots in your stomach. Bad depression was another side effect which blows my mind since you'd think looking better would make you feel great. And these were the minor things.

> Bad depression was another side effect What? Ozempic has been noted for its mild _anti_ depression activity.

both can be true. it can reduce depression in 60% of people and increase it in 10%

Re: Weight-loss drug found to shrink muscle in mice, human cells

#242

Post by inamberclad »

kbos87 wrote: post #137

There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss. For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

Anecdotes don't equal data. "Always" and "never" don't exist in medicine. I'm sure that your experience is accurate to yourself, but these studies have to cast a wider net since there is always variability in results.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#243

Post by tokioyoyo »

echoangle wrote: post #234
tokioyoyo wrote: post #227

Earlier quoted context omitted.

I don't think you realize the amount of people have taken Ozempic or similar drug. I'm lucky enough that I haven't had issues with body weight, but if I believe the stats (and my observations in real world confirm it), about 15% of adults are on it. If it was "killing people", we would be seeing it literally everywhere. We're not talking about a small scale 50K+ observation... we're talking about literal millions.

This says 6% are currently on a GLP-1 drug and 15% have ever taken one in their life: https://amp.cnn.com/cnn/2024/05/10/health/ozempic-glp-1-surv...

Fair, I remembered my stats wrong. But it's still 15M people in US that are actively on it. That's a lot of people.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#244

Post by globular-toast »

diath wrote: post #207

The problem with appetite suppression drugs is that they simply make you not feel hungry, but do nothing to fix your lack of discipline and self-control, I'm sure most people who lose weight on these drugs, and then come off, will just go back to their bad habits.

Yeah, I am sceptical, but we'll have to see how it pans out.

Vanishingly few people succeed in exercising discipline and self-control long term. But obesity is caused by food addiction and the idea is once you've kicked the addiction and got over the withdrawal etc then it's gone and you no longer have to fight it. I don't "exercise discipline" to stay thin. I just don't eat copious amounts of junk food because I'm not addicted to it.

So if the drugs are used to soften the withdrawal symptoms such that people can learn to like real food and kick the addictive crap then that's good. But if they're used as a magic pill with no other lifestyle changes then I'm sure people will just go back to what they were doing before once those pangs come back.

I'd still rather we went after the industry peddling the addictive shit. We went after the cigarette companies. But food companies seem untouchable.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#246

Post by Agingcoder »

phil21 wrote: post #217
jjallen wrote: post #203

Earlier quoted context omitted.

For the people who lift weights while on this/these drugs, how much lean muscle do they lose? The point is is that most people lose muscle because they’re not lifting. You will lose muscle if you lose weight no matter the cause, if you are not lifting weights.

Not sure how much I lost during, but a substantial amount. I have been working out since about 20lbs from my goal weight and now roughly a year later - and have gained strength (based on the numbers I can lift) from before I lost 100lbs. I don’t think it would have been possible to not lose substantial muscle mass while rapidly losing 100lbs over 9mo, even with extreme resistance training added to the mix. While DEXA…

100 lbs that’s significant. What are the implications of rapidly losing weight ? ( I’d expect even your body image changing to not be very easy )

Re: Weight-loss drug found to shrink muscle in mice, human cells

#247

Post by hackernewds »

httpz wrote: post #21

Some of the side effects of semaglutide are just a result of eating less calories. Without a control group who also ate the same amount of calories but without the drug, it's hard to know if the side effect were directly caused by semaglutide or just a result of being in a calorie deficit.

well it does lead to less eating so it indeed a side effect. if control group ate the same amount there would be no weight loss to begin with.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#248

Post by apwell23 »

kbos87 wrote: post #137

There are a lot of people here citing loss of muscle mass as a side effect of GLP-1s, when the reality is that weight loss almost always comes with muscle loss. For me, that hasn't even been the case. I'm down 40lbs on a relatively low dose of Semaglutide and my muscle mass has moderately increased over the last 6 months. The hysteria over this is totally unfounded.

> low dose of Semaglutide

I thought its only approved at standard dose.

Re: Weight-loss drug found to shrink muscle in mice, human cells

#249

Post by andbberger »

echoangle wrote: post #212
diath wrote: post #207

The problem with appetite suppression drugs is that they simply make you not feel hungry, but do nothing to fix your lack of discipline and self-control, I'm sure most people who lose weight on these drugs, and then come off, will just go back to their bad habits.

So why not just stay on the drugs?

$$$
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