In case you didn't know, sleeping on your right side maximizes the clearance effect, while sleeping on your stomach minimizes it.
[in mice]
I'm imagining a row of little mice sleeping on their right side in a lab experiment
Brain waves appear to wash out waste during sleep in mice
241–250 of 270 posts
Re: Brain waves appear to wash out waste during sleep in mice
#242Earlier quoted context omitted.
Promethazine the Proud! Flamer of Flames! Gayest of Gallopers!!! Sounds like the name of a Centaur Character in any D&D style game.
You had "Phenibut" right there and you went with Promethazine?
(sorry - but I am not sure if you are making a ref I dont get but "Promethezine" is the actual name of the pharma-thingy...
If you made a popculture ref, I miss...
:-) aleays participate though
Re: Brain waves appear to wash out waste during sleep in mice
#243that explains why my brain is full of trash and I love sleep but rarely get it
Re: Brain waves appear to wash out waste during sleep in mice
#244Earlier quoted context omitted.
I must be spending too much time on HN. I recognize this exact comment from a month ago.
I was thinking the same thing, but I wasn't sure how long ago it was.
Re: Brain waves appear to wash out waste during sleep in mice
#245Earlier quoted context omitted.
It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…
Promethazine (1) helps some people, myself included (UK Sominex). And occasionally, phenibut. (1) https://www.inhousepharmacy.vu/p-1189-phenergan-tablets-25mg...
1st gen antihistamines = dementia, phenibut = the worst withdrawal mankind has to offer
Re: Brain waves appear to wash out waste during sleep in mice
#246Earlier quoted context omitted.
It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…
If the problem is psychological trauma, wouldn’t therapy be the obvious solution?
you say that so flippantly
Re: Brain waves appear to wash out waste during sleep in mice
#247Earlier quoted context omitted.
It makes me sad as my SO struggles a lot with sleep. It's been years since she's had a good nights sleep. Sadly her issues are mostly psychologically rooted due to past trauma, while all the treatments seem to be geared towards "simple" physical issues. She's tried contacting various sleep clinics here and they've all said they can't help. She struggles a lot with falling asleep, she's exceptionally sensitive to soun…
How healthy is she in general? Does she eat well? Exercise? Have a consistent night routing? Has she tried melatonin? What about sleep apnea? If she's sensitive to sound and light, what has she tried to address that? Like blackout curtains? I find it a bit odd that sleep clinics would turn her away so readily. I understand the struggle though which is why I asked so many questions, because all of these things have fa…
Yes, healthy, eats well and exercises daily, has blackout curtains and sleeps with plugs. No apnea.
As sibling reply says, clinics seem to treat sleep apnea and similar direct physical causes, as well as provide very basic information.
She got a referral from her doctor but all the ones she contacted were very clear they couldn't do anything for her so wouldn't even take her in for observation.
Re: Brain waves appear to wash out waste during sleep in mice
#248Earlier quoted context omitted.
The root cause is psychological, but it's manifested itself in physical changes. She's hyper-sensitive to certain sounds for example, which causes her to not be able to fall asleep, or to abruptly wake up. Mostly low frequency sounds, so hard to block. But yeah, as I mention in a reply to a sibling comment, she's tried therapy for years without much progress, though recently making some progress on that front.
I know it really sucks and have struggled with it myself for a long time. Two things really worked for me. Try these: https://www.loopearplugs.com/products/quiet And at the same time have some calming barely perceptible background noise from a speaker somewhere in the room. White noise, brown noise, lofi, whatever works. Make sure the bedroom has blackout curtains and soft light. As for cannabis, she doesn't have to…
As someone who was diagnosed with severe ADHD 20 years ago, marijuana makes my brain far more active. If if I have an edible around 5pm, I won’t sleep until 1am (I normally go to sleep by 9/9:30). I constantly want to do things. For me, weed is an upper.
My wife and my girlfriend are both jealous of the effect it has on me. But I’m jealous on the sleep-inducing or calming effect it has on them.
Please don’t assume marijuana affects everyone equally. It may work, but if it doesn’t, your girlfriend will know immediately so you can stop trying it. Ask her how marijuana normally affects her before trying that.
Re: Brain waves appear to wash out waste during sleep in mice
#249Earlier quoted context omitted.
I know it really sucks and have struggled with it myself for a long time. Two things really worked for me. Try these: https://www.loopearplugs.com/products/quiet And at the same time have some calming barely perceptible background noise from a speaker somewhere in the room. White noise, brown noise, lofi, whatever works. Make sure the bedroom has blackout curtains and soft light. As for cannabis, she doesn't have to…
As someone who was diagnosed with severe ADHD 20 years ago, marijuana makes my brain far more active. If if I have an edible around 5pm, I won’t sleep until 1am (I normally go to sleep by 9/9:30). I constantly want to do things. For me, weed is an upper. My wife and my girlfriend are both jealous of the effect it has on me. But I’m jealous on the sleep-inducing or calming effect it has on them. Please don’t assume ma…
Note I wrote appropriate edibles. There is a variety.
I leave it to you to research a bit further and perhaps try different kinds, with some trial and error you may get lucky yet.
Re: Brain waves appear to wash out waste during sleep in mice
#250If you have any doubts about sleep quantity and quality, worth reading about the glymphatic nervous system, which is so newly discovered likely you didn’t learn about it in school. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636982/ In short it explains, mechanistically, why poor sleep affects daily cognition, mental health, and age-related declines. Robust scientific theories explain more of the evidence. The glym…
I must be spending too much time on HN. I recognize this exact comment from a month ago.
I’m thinking it should be pinned to the top of any sleep post!