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Medications that change who we are

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241–250 of 289 posts

Re: Medications that change who we are

#241

Earlier quoted context omitted.

Also, personalities tend to change if the testes are removed.

There's a huge family of "Neurosteroids"[1], which impact various receptors in the brain in lots of super complicated ways that aren't entirely understood. They are synthesized in all kinds of ways naturally, and when it comes to "what they do" in terms of personality... "probably something" is the best we can do. There is massive complexity in all these things, all kinds of feedback mechanisms, genes and enzymes inv…

Sure, but also if you neuter a cat, it'll be less prone to fight with other cats or to mark its "territory" with urine.

Re: Medications that change who we are

#242

I take gabapentin for a spinal issue (nerve damage in my spine) and it has a drastic and noticeable effect, I'm naturally quiet and introverted but when I take the higher prescribed dose that changes radically, I become outgoing and talkative, I have more confidence and I seem to be more creative (though that could just be the reduction in pain). It definitely alters my mood and I can feel it happen.

which is interesting, because the dosage range for gabapentin is, to put it mildly, all over the place: 100-3,600 mg/day

https://slatestarcodex.com/2019/07/18/know-your-gabapentinoi...

Re: Medications that change who we are

#243
post #115

Wow, turns out there's a lot of studies into e.g. paracetamol out there too. e.g. https://www.ncbi.nlm.nih.gov/pubmed/31523834 More here: https://twitter.com/autismepi/status/1214388671752916992/pho...

There were few associations with behavioural or neurocognitive outcomes after age 7-8 years, whether reported by the mother or the teacher.

If paracetamol use in mid-to-late pregnancy has an adverse effect on child neurocognitive outcome, it appears to mainly relate to the pre-school period. It is important that these results be tested using other datasets or methodologies before assuming that they are causal.

translation: "we studied it and no, tylenol doesn't cause autism; calm your pants."

Re: Medications that change who we are

#244

Earlier quoted context omitted.

And where are the studies regarding post transition surgery regret? I would caution you to be very careful in forming your opinion from modern research in the field. The institution has undeniably accumulated a very strong bias with the emergent result that published results (and research direction) tends to be very one sided. But looking in from the outside, I absolutely cannot take seriously an establishment which…

I don't have statistics on-hand, but as I understand it, bottom surgery (SRS, GRS, whatever you want to call it) has one of the absolute highest patient satisfaction rates of any major surgery (including lifesaving surgeries). > permanent genital mutilation which results in a potential lifetime of pain from daily dilation of an artificial orifice which is little more than a glorified wound Pretty much every single wo…

> I don't have statistics on-hand, but as I understand it, bottom surgery (SRS, GRS, whatever you want to call it) has one of the absolute highest patient satisfaction rates of any major surgery (including lifesaving surgeries

I think you really do need to cite these statistics given the controversial nature of the subject matter in hand.

Re: Medications that change who we are

#245

Earlier quoted context omitted.

Is it not abundantly clear that a photon is just a photon? What else could it be? > the perception of red is the chemical cascade starting with the stimulation of L-cones and ending with the firing of neurons in the visual cortex. So this quote illustrates the gist of your thinking, but I think you've got some muddled terms. For you there is "red light" and "the perception of red". So for you: "red light" is the phot…

> Is it not abundantly clear that a photon is just a photon? What else could it be? Well, light can be modeled as either a wave or a particle[1]. When talking about colors, it makes more sense to talk about light using the wave model of light than the particle model of light--not that either way of talking about it is wrong, it's just that the particle model is way more complicated for modeling this particular phenom…

A lot of what you say is irrelevant. I get the feeling you aren't aware of the hard problem of consciousness, so I'll leave this here for you to read up on: https://en.wikipedia.org/wiki/Hard_problem_of_consciousness. Are you familiar with concepts like qualia? I recommend reading that wiki too.

The problem for you is that you still fail to draw a distinction between 2 highly correlated phenomena: the chemical cascade & the perception of red. You even get close to admitting the distinction yourself. E.g.:

> People who have the chemical cascade experience red. People who don't, don't--even if red light is there (i.e. if they are colorblind). Do you have any reason for believing these are different phenomena?

So yes, many reasons - some of which have already been explained and inadequately responded to, but here's another example that should prove it to you: We can put someone under anesthesia, shine red light into their eyes & they will still have the chemical cascade, but will not experience or perceive red. How do you square this circle? I suspect you'll insist they must also experience it and simply not know, but I'll be interested in hearing your mental gymnastics.

> It's also in the brain, because the mind is just the brain.

> This isn't hypothetical. We can read (very) fuzzy images from people's brains using neural-imaging[2]. I'm not aware of any experiments that specifically has read a red triangle, but I don't see any reason to believe that this image is uniquely in the mind and not the brain.

I've looked at brains under the microscope... never once have I seen a red triangle, or green square, or blue circle, yet here they are in my mind. Again your confusing correlation for the thing itself.

Yes I'm sure we'll get to the point where if I imagine a red triangle, then we'll be able to "read" it from my brain, but this doesn't mean that the red triangle is in my brain, just that a certain activity of neurons in the brain is correlated with a red triangle... those neural imaging techniques are all largely about correlation, which is my point exactly.

> If it's qualitatively different, what are the qualitative differences?

The brain is made of traditional matter we're familiar with (e.g. atoms and their constituent parts, amongst others), but the mind is made up of things like sense-perceptions (e.g. the colour red or the smell of lemons, which are fundamentally irreducible - by which I mean you cannot say the perception of a red triangle is made up of traditional matter. Instead a red triangle is simply made up of red; in essence, if a red triangle is made up of atoms, those atoms would have the quality red, which is a property traditional matter does not possess, hence the mind being made up of qualitatively different matter than the brain.

I know it's probably hard for someone who refuses to believe consciousness exists to admit that consciousness does in fact exist as a separate distinct phenomenon, so I won't try too hard to convince you. I'm sure with time you'll make that distinction too.

Re: Medications that change who we are

#246

Earlier quoted context omitted.

I didn't mean to make this about transgender medicine. The evidence is pretty strong that hormone treatment improves wellbeing for transgender patients[1], and of course, they can always stop it if it doesn't. The fact that very few do is a good indicator of satisfaction overall. There is a very strong bias towards safety in the practice of transgender medicine. I can also personally attest that transgender medicine…

And where are the studies regarding post transition surgery regret? I would caution you to be very careful in forming your opinion from modern research in the field. The institution has undeniably accumulated a very strong bias with the emergent result that published results (and research direction) tends to be very one sided. But looking in from the outside, I absolutely cannot take seriously an establishment which…

I've vouched for your comment which was flagged, I think you make some reasonable points, if somewhat clumsy, but are valid for discussion, especially in regards to children. If the parent poster is an adult then I'm fine with what they wish to do to their body.

I don't have an axe to grind regarding top or bottom surgery in adults. But given the current troubling reports about the activities of the Tavistock clinic, especially with regards to children being supplied puberty blockers etc and perhaps regrettable surgeries (offshore by ill informed parents), this warrants more rigorous study by the health profession.

Re: Medications that change who we are

#247
There's a wee bit of me feels I need to ask the question, is this years later, the Andrew Wakefield effect rearing its head again[0]?

Very small samples of and affected medicated population being used to push an agenda? Sure I realise the brain and body are deeply interconnected, but until we invest time and money in valid studies, how can we possibly know the outcomes of prescribing statins, paracetamol etc in terms of human behaviour.

For the vast majority of the population taking these drugs are generally safe (yes I know about drug allergies, which is a different thing), but I imagine there will be in a minuscule percentage of a population, long term, there may be side effects. I think this should be researched, but this sounds like a scare story.

[0]: https://en.wikipedia.org/wiki/Andrew_Wakefield

Re: Medications that change who we are

#248

Earlier quoted context omitted.

I don't have statistics on-hand, but as I understand it, bottom surgery (SRS, GRS, whatever you want to call it) has one of the absolute highest patient satisfaction rates of any major surgery (including lifesaving surgeries). > permanent genital mutilation which results in a potential lifetime of pain from daily dilation of an artificial orifice which is little more than a glorified wound Pretty much every single wo…

> I don't have statistics on-hand, but as I understand it, bottom surgery (SRS, GRS, whatever you want to call it) has one of the absolute highest patient satisfaction rates of any major surgery (including lifesaving surgeries I think you really do need to cite these statistics given the controversial nature of the subject matter in hand.

It's actually not controversial at all among the people actually impacted by it. It's only "controversial" in that a lot of people are transphobic and are offended that trans people are allowed access to gender-affirming medical care.

Besides, nobody's asking for statistics on how many people are satisfied with surgery to remove cancer, or other "obviously" good surgeries. Why are we expected to justify the existence of gender-affirming surgeries?

Re: Medications that change who we are

#249

Earlier quoted context omitted.

> I don't have statistics on-hand, but as I understand it, bottom surgery (SRS, GRS, whatever you want to call it) has one of the absolute highest patient satisfaction rates of any major surgery (including lifesaving surgeries I think you really do need to cite these statistics given the controversial nature of the subject matter in hand.

It's actually not controversial at all among the people actually impacted by it. It's only "controversial" in that a lot of people are transphobic and are offended that trans people are allowed access to gender-affirming medical care. Besides, nobody's asking for statistics on how many people are satisfied with surgery to remove cancer, or other "obviously" good surgeries. Why are we expected to justify the existence…

> It's actually not controversial at all among the people actually impacted by it.

Confirmation bias much?

> a lot of people are transphobic and are offended that trans people are allowed access to gender-affirming medical care.

Again, stats please, ideally by country so we might have a proper discussion.

> Besides, nobody's asking for statistics on how many people are satisfied with surgery to remove cancer, or other "obviously" good surgeries.

Sorry, but that does actually happen, they're called survival statistic, most, if not all health care systems record them. People who survive cancer are generally happy they're alive.

> gender-affirming surgeries

There's no such thing as "gender-affirming surgeries", they're called sex changes. Gender is a role unlike biological sex.

Re: Medications that change who we are

#250
post #225
post #211

Earlier quoted context omitted.

Are you blaming Trump on the trans? That's a funny new perspective! But joke aside, why would hormones only work in one way? And why couldn't you say the same about, say acetaminophen? Without a RCT your guess is as good as mine!

Sorry, not following. I don't have any deep knowledge about the subject more than I historically been interested in fitness and bodybuilding and with that comes some knowledge about hormones. Not saying "roid rage" is not impossible but the studies I saw was that the idea mainly came from people in criminal circles who often used a multitude of drugs who wanted to be bigger and more intimidating and then drank some a…

Fair enough!
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