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The shingles vaccine may reduce the risk of dementia

economist.com

231–234 of 234 posts

Re: The shingles vaccine may reduce the risk of dementia

#231

I know quite a few people who got shingles in their early 20s. One of their doctors didn’t believe she had shingles until the blisters formed. The vaccine can definitely help those younger than 50, dementia benefits or not. Some of them have permanent nerve damage after getting shingles.

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Re: The shingles vaccine may reduce the risk of dementia

#232
post #46

So if you had shingles in your youth then you are better protected against dementia?

The article says that one possible reason the vaccine protects against dementia is incidental protection from other diseases. Getting chickenpox as a kid might protect you against shingles, but maybe not against those other diseases.

Chickenpox vaccination does increase shingles cases, but mainly in young adults https://www.sciencedaily.com/releases/2015/08/150811103555.h...

Re: The shingles vaccine may reduce the risk of dementia

#233

Earlier quoted context omitted.

That’s possible (although the plaque hypothesis as the sole cause is looking less plausible). But that’s not what the study is saying. It’s literally just saying that older doctors are more likely than younger doctors to have dementia. Also that study only looks at dementia and Alzheimer’s only accounts for ~2/3 of cases.

Plaque is the end-cause. What's debatable is why it accumulates and what pharmaceuticals and interventions we doctors should prescribe for our patients, not whether it's present or not.

Isn't cholesterol released into the bloodstream to protect arteries when it gets acidic, and over time turning into plaque buildup? Also, going the other way doesn't help either because if you got a spike in acid your arteries wouldn't cope with the overload

Re: The shingles vaccine may reduce the risk of dementia

#234

Earlier quoted context omitted.

Plaque is the end-cause. What's debatable is why it accumulates and what pharmaceuticals and interventions we doctors should prescribe for our patients, not whether it's present or not.

Isn't cholesterol released into the bloodstream to protect arteries when it gets acidic, and over time turning into plaque buildup? Also, going the other way doesn't help either because if you got a spike in acid your arteries wouldn't cope with the overload

I'm not sure what you're referring to re: Alzheimer's plaque. They're not the same type of "plaque". Alzheimer's is basically little pieces of protein that clumped together and the body couldn't get rid of it. Generally, pH changes can affect proteins and lead to their clumping, but that's not the mechanism here. It's when there's too much of these abnormal proteins that normally get filtered away. It's generally called "amyloidosis". There's many theories for why: some think it's linked to bacteria from our mouths getting into the brain, some think it's because the glymphatic system got clogged (healthy flow of CSF fluid, like clogging of certain holes where it's supposed to flow more freely, etc, etc). Not the same substance as arterial plaque.
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