Covid-19 mRNA Vaccination and 4-Year All-Cause Mortality

mRNA is just a molecule that breaks down, and the mRNA in these vaccines is extremely fragile and temporary. Once injected it enters whatever cells are nearby (muscle cells)and ribosomes read it to produce the inert spike protein. The mRNA itself is gone within hours. Your cells have enzymes specifically designed to break down RNA because cells naturally produce and dispose of mRNA constantly as part of normal function.

The mRNA in vaccines never enters the cell nucleus where DNA is stored, so it can't integrate into your genome or affect reproductive cells in that way. And it doesn't replicate itself either.

And millions of babies have been born to vaccinated parents by now. If the effects you are talking about were even possible they would definitely have shown up by now.

Blame them for what, exactly?

We have no information about how highly motivated anti-vaxxers in positions of power over the FDA arrived at this conclusion except "the team has performed an initial analysis"[1]. That's literally it. Your claim that "FDA career scientists" conducted the follow-up can't even be based on this flimsy a statement. Moreover, these deaths have already been investigated by FDA career scientists and found these conclusions unwarranted.

Prasad spends the rest of the memo politically grandstanding (including claiming it was the FDA commissioner that was the hero here, forcing this issue, not FDA career scientists) and dismissing any objections to very obvious arguments against his claim (that have been made and published multiple times over the past five years) without any evidence, while providing no evidence of his own, in a memo addressing FDA career scientists.

Seriously, everyone should go read his memo. It's basically just a shitty antivax substack post, yet will apparently be FDA policy going forward. Another win for meritocracy.

> The detailed FDA analysis still isn't public. That's exactly why we should demand it instead of dismissing the claim.

The only "claim" here just sounds more official because RFKjr got a bunch of his best antivax buddies to be in charge of the FDA (same with the ACIP). There's no way to even consider it without evidence, so there's nothing to dismiss. Come back when you have something real.

[1] https://www.biocentury.com/article/657740

We don't actually know who at the OBPV did the review (Prasad only referred to the results coming from "the team") and the causal ranking they used included any case where causality was subjectively rated between "certain" and "possible/likely".

We also know that two orders of magnitude more children died from covid than that, and we have strong studies suggesting that myocarditis from covid is both more common and more severe than the observed cases tied to the covid vaccines, two inconvenient stances that Prasad waves away as insufficiently studied, even as he bases his entire position on a subjective review of something by someone, and doesn't bother filling in those blanks.

> If the conclusion was fake or flimsy, this blows up in their face and RFK looks like a clown

He beclowns himself all the time. He himself walked back the Tylenol claim after convincing Trump to talk about it so publicly and standing by him while he did it. Clearly he's not bothered by it.

I'm not sure why. The top causes for that age group are usually non-medical, accident, suicide, or homicide. We might speculate those would anticorrelate more strongly with the prudence that leads people to get the vaccine than unavoidable medical causes, but looking at the V, W, X, and Y causes from Table 2 that doesn't seem to be true. I guess it could be true but only for the 18-29 group (and if it's not then what causes are responsible?), since they don't break that down by age.

The "problem" is that vaccine recipients are so much healthier overall than non-recipients that the vaccine would have to be spectacularly unsafe to offset that. So this analysis doesn't actually tell us much, but it's consistent with all other evidence that the vaccine is safe.