Looking into this So I built out CyberKnife building at ECH in 2009...
and was just thinking about the vid you had, and how they are using the ultrasound intersections "at the blood brain barrier
Where exactly is this intersection occurring?
Is it poking a hole in something for the plaque to 'flow through' via the cereberal flush?
--
Ah I have my answer::
The transiant gap created by FUS will last a few hours...
So - here is where a few LLM ideas come to mind - as the gap allows for the flow of the enzymes through for a bit before they heal - what is the optimal location for placing the FUS pulses?
How many FUS pulses required to create the gap is unclear, as is exactly how long it takes for the enzyme flush - however, there is currently (mostly?) single point systems, but multi-point systems are being tested. What would be interesting to determine is if there could be a spatial pattern for placing the gaps, assuming you have a multi-point FUS system, imagine creating (N) FUS gaps simultaniously in a pattern which followed the natural flow of the enzyme flush - such that if the cereberal flush is flowing in a clockwise fashion - openening FUS gaps in accordance with the direction and timing of the enzyme flush's frequency. directed flow FUS animation.
It seems you dont have to explicitly open a gap with a FUS pulse - so can "massage" behavior such that you can direct flow? I guess only depending on the frequency with which you can aim and fire FUS pulses - but if you have multiple FUS sources? you can 'kite' the flow in...
which reinforces this: "In the context of Alzheimer’s disease, post-FUS tracer enhancement phenomena suggest the existence of a brain-wide perivenous fluid efflux pathway in humans4. This could potentially facilitate the drainage of harmful substances
I wonder what the energy consumption per pulse, how many pulses per gap, how many gaps per hour.
https://www.elcaminohealth.org/news/el-camino-hospital-purch...
---
But what would be really interesting is the marriage of a multi point FUS system layered on top of a cyberknife where as the cyberknife uses xrays to track the position of the prostate in order to determing the location of the point its 'knifing' - if you can massage points into position using FUS - maybe a multi-point FUS can hold a prostates target in position in sync with the cyberknifes 'knifing' and validation via xrays?
-- ala:
Focused Ultrasound (FUS) and the Blood-Brain Barrier (BBB): FUS has been shown to disrupt the BBB in a noninvasive, safe, and targeted manner1. The mechanical effects of FUS, namely cavitation, are thought to be the principle cause behind this BBB disruption1. This method of BBB disruption – FUS with microbubbles – has had very promising results1.
CyberKnife and Prostate Treatment: The CyberKnife System uses advanced technologies to track tumors anywhere in the body, while its unique robotic design keeps the radiation on target even while the tumor moves2. Before delivering the radiation beam, the CyberKnife System verifies the exact tumor position then adjusts the robot to precisely target the tumor2. This system is particularly effective for treating prostate cancer345.
Potential Combination of FUS and CyberKnife: In theory, a multi-point FUS system could potentially be used to “hold” a prostate target in position, working in sync with the CyberKnife’s tracking and ‘knifing’. This could potentially enhance the precision of the treatment, as the FUS system could help ensure the prostate remains in the optimal position for the CyberKnife treatment.