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We could have universal Covid vaccines soon

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Re: We could have universal Covid vaccines soon

#231

Post by Vecr »

jameshart wrote: post #130
peyton wrote: post #44

Earlier quoted context omitted.

Lots of people I know parrot “safe and effective” whenever testing positive. Turning an FDA-regulated phrase into a joke doesn’t bode well for future trust in government scientists.

Lots of living, nonhospitalized people, who are catching a preventable disease because community vaccine uptake wasn't as high as it needed to be to really stamp out the disease... ... have somehow reached the conclusion that the vaccine which did them no harm whatsoever, and is responsible for their being likely to have a very mild case of the disease, was not safe or effective? Why on earth have they reached that c…

> because community vaccine uptake wasn't as high as it needed to be to really stamp out the disease...

No, that's never going to happen, and never was going to happen. Even the FDA presenters to VRBPAC (Peter Marks? Can't remember exactly) admit it. That's even without spillover and spillback between humans, deer, cats, etc. This type of virus is absolutely not a candidate for eradication, even the most optimistic predictions from before the pandemic would have required the periodic stamping out of spillover related outbreaks across the world for the foreseeable future.

Re: We could have universal Covid vaccines soon

#232

Post by Vecr »

divbzero wrote: post #222
ars wrote: post #192

Earlier quoted context omitted.

The loss of immunity is not due to variants. The immune system itself simply starts forgetting.

What part of the immune system are you referring to? My understanding is that the initial set of antibodies wane over time but will be produced again if memory B cells encounter the same antigen. Similarly, T cells specific for an antigen will amplify in number if re-exposed to that antigen.

The serial interval of the virus is so fast that there's no way the T-cells and B-cells can keep up. Some sort of nasal vaccine could reduce infection for a few months but as far as I can tell it's impossible to make a long lasting (years) coronavirus vaccine that can prevent infection. Serial interval is too fast, antibodies wane too fast, your immune system is too slow. I could see a gene therapy/retrovirus thing that hijacks some cells permanently to produce antigens (or make it smarter and somewhat regulating like an HIV infection, if HIV is forever this could be too) so it's like getting vaccinated every minute of every hour of every day, forever. Alternatively, you could produce genetically engineered B-cells in the lab and inject them into people ('s bone marrow?) to constantly produce a very high dose cocktail of broadly neutralizing antibodies. Completely infeasible, too expensive, won't scale. Might work. None of these ideas would be approved for the general public in at least 25 years.

Re: We could have universal Covid vaccines soon

#234

Post by [deleted] »

Ekaros wrote: post #227
joeman1000 wrote: post #73

Earlier quoted context omitted.

We are forced to in Australia. I was barred from taking exams this semester since I didn’t have the vaccine. Others lose their jobs. There is no freedom of choice there. It’s a gun wrapped in a blanket.

This is what fascism looks like. The totalitarians are winning. It is sad that freedom means nothing anymore to these people...

[deleted]

Re: We could have universal Covid vaccines soon

#235

Post by bawolff »

Ekaros wrote: post #230
bawolff wrote: post #229

Earlier quoted context omitted.

Really, because: Let me do the math... $0+$0 = $0 Seems pretty cheap to me. Maybe if you mean for gov who pays, but even then, in terms of health care budget, its still quite cheap, to the point that optimizing on price seems like the wrong thing to do right now.

Did that include increased taxation? Including bribes, inefficient bureaucracy and manufactures, their sales organizations and the point-of-care healthcare increasing their profits?

I mean,im in canada, and the non vaccinated take a lot of tax dollars when they end up in hospitals, so in terms of interventions it definitely makes sense from an ecconomic perspective.

Re: We could have universal Covid vaccines soon

#236

Post by ephimetheus »

to1y wrote: post #93
jmyeet wrote: post #66

Earlier quoted context omitted.

> So much damage has been done to public trust Anti-vaxxers aren't new. What we have here is an unhealthy mix of exceptionalism, anti-intellectualism and contrarianism. There is a psychological comfort in believing you' can see through the [Big Lie/Conspiracy]. Prior to Covid it was autism and vaccine. When was the last time you heard about that? Before Covid. Why? Because we've moved on to another vaccine to be skep…

Well the polio vaccine left people blind iirc. Unfortunately the anti-vax group isnt completely crazy this time. If you haven't seen or heard of adverse reactions click your heels and go kiss your mother: you're one of the lucky ones. I had to get the vac for int travel and to this day, 6 months later, I still have not recovered my strength. I had covid before that and since then, the first time I barely noticed it,…

I know literally not a single person who has had a severe reaction to any of the vaccines.

I find it fascinating that on HN anecdata that conforms with the vaccine being dangerous is totally accepted, but anecdata about people getting very sick from COVID are either considered lies or statistical outliers.

Re: We could have universal Covid vaccines soon

#238

Post by edmcnulty101 »

Doyce wrote: post #191
edmcnulty101 wrote: post #178

Earlier quoted context omitted.

This is all false information and needs to be flagged. Just one study from Hopkins addressing your first point. https://www.hopkinsmedicine.org/health/conditions-and-diseas... .

Quoted post unavailable.

Your comment is dead. And this comment needs to be dead as well.

No scientist would agree with you that Natural immunity only last a few months. It goes against very basic science.

You created these posts from an account with 3 karma and used echo360.com as your source....you're promulgating false information from a fake account.

Re: We could have universal Covid vaccines soon

#239

Post by edmcnulty101 »

mattnewton wrote: post #39
SoftTalker wrote: post #14

Earlier quoted context omitted.

People's immune systems are not all the same. Some people hardly ever get sick. Some people seem to hardly ever be well. And everything in between.

Right, of course. I guess I mean for a given individual (who can’t change their immune system), the poster seemed to imply that the choice to be vaccinated was neutral or negative.

For a person with a healthy immune system the choice to be vaccinated is neutral or negative. This includes non-immunocompromised people under the age of 65.

Re: We could have universal Covid vaccines soon

#240

Post by edmcnulty101 »

Doyce wrote: post #158
ekianjo wrote: post #65

Earlier quoted context omitted.

> , so there's no need to draw conclusions from a single anecdote In the meantime we are still waiting for the raw data to be made public about Pfizer's vaccine trials. Strange that we can inject billions on people on Earth yet nobody apart from a selected few were allowed to see that.

Didn't the FDA release like 60k pages of those documents a couple months ago? I know Pfizer didn't want that, but people are forgetting before COVID mRNA medicine was a holy grail. So much so a lot of groups didn't pursue it since they saw it as a pipe dream. COVID's greatest gift was causing massive influxes of research dollars into them and most likely fast tracking these new drugs 15 years. mRna will literally be…

> We've had roughly (last time I checked several months ago) a couple of dozen verified deaths relating to the vaccine

"Verified"

> That's not really reported because anyone who expects every single human on the planet to have zero negative reaction to a drug

Exactly, so why take the risk if you're not in a vulnerable group to Covid.

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