Antiplatelet and anticoagulant therapy resolves long covid in 24 patients • Hacker News Board

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#231

Post by yosame » Fri, Jan 07, 2022, 5:31 AM UTC

dolni wrote: post #225

yosame wrote: post #219

Earlier quoted context omitted.

If ivermectin actually worked, pharma companies would just make a new version with a slightly different structure and patent/sell that formula instead.

No they wouldn't, because it would be trivially outcompeted by current ivermectin which can be had for very, very cheaply.

Then why hasn't the same thing happened to ketamine for the treatment of depression?

Ketamine is widely available and cheap, but the FDA approved esketamine (the S enantiomer of ketamine) and gave the pharma companies a patent for the formulation so they would fund the clinical trials that are needed for it to be used as a treatment of depression.

Esketamine is much, much more expensive than ketamine, and essentially the same molecule, yet it hasn't been 'outcompeted' by ketamine (in the context of treating depression).

Because the new ivermectin (newermectin) would be specifically authorised and used to treat covid, it would have a niche advantage over ivermectin. Ivermectin would still dominate treating parasites, but there would still be good money in developing newermectin.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#232

Post by TechBro8615 » Fri, Jan 07, 2022, 6:09 AM UTC

mikeyouse wrote: post #158

TechBro8615 wrote: post #142

Earlier quoted context omitted.

Do you have any substantive critique to offer of the various lemmas established throughout the piece, which refers to itself as “an argument and petition for plurality under Ockham’s Razor?” Or do you rely solely on appeals to authority when filtering signal from noise? I’ve noticed throughout this pandemic that many arguments supported on such a weak basis have later been disproven or severely undercut by further ev…

Are there any conspiracy theories you don't believe or do you just assume they're all equally plausible? It's a workday and I'm busy but I'll grant you one substantive critique; the OP heavily relies on "mutations per year" as a metric to derive how plausible it is that something like Omicron could have mutated in the timeframe necessary. Does it strike you as a bit suspect to rely on a mutations/time period, and com…

> Are there any conspiracy theories you don't believe

I don’t like words like “believe” that imply a reliance on faith. I seek truth through evidence and my goal is to filter signal from noise.

> Does it strike you as a bit suspect to rely on a mutations/time period, and completely ignore the number of infections?

I’m far from a virologist, but I think OP’s postulation around mutation frequency is a bit more subtle than simply N / time.

See Exhibit [7.7] for example, which makes it visually clear just how distinct omicron is from any other variant. I’m not qualified to speculate beyond this, but it seems OP is saying a bit more than “there are a lot of mutations” – indeed, he spends multiple sections disambiguating the evidence of pure volume of mutations from that of phylogenetic distance. Still, you may have a point — maybe it only takes one mutation into a new dominant “clade” to produce such distinction, with any subsequent mutation being of little surprise given the prevalence established by the first one.

> It's a workday and I'm busy

On this we can agree.

[7.7] https://i0.wp.com/theethicalskeptic.com/wp-content/uploads/2...

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#233

Post by kahrl » Fri, Jan 07, 2022, 3:32 PM UTC

QuercusMax wrote: post #146

kahrl wrote: post #130

Earlier quoted context omitted.

Yes. Absolutely. GI issues are some of the most common medical problems. Ucers, polyps, sores, diverticula...

My dad got a hole in his stomach from taking too much Advil (ibuprofen) for pain related to a broken vertebra.

jeez. NSAIDs can do some nasty stuff when taken regularly. Most people just pop 'em like candy.

Re: Antiplatelet and anticoagulant therapy resolves long covid in 24 patients

#234

Post by ouid » Sat, Jan 15, 2022, 8:44 AM UTC

sheinsheish wrote: post #77

ouid wrote: post #52

Earlier quoted context omitted.

Mechanistically, placebo can only work on psychosomatic symptoms. There isn't any magic going on. If the problem is in your head, then thoughts can maybe help.

Please reconsider after having a look on Joe Dispenza’s book. https://www.goodreads.com/book/show/18051504-you-are-the-pla... At least consider the possibility that maybe (maybe = 10-50% chance?) there can be magic in our heads & bodies.

no