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Post-SSRI sexual dysfunction

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Re: Post-SSRI sexual dysfunction

#231

Post by bongoman37 »

sizzle wrote: post #97
aserdf wrote: post #77

Earlier quoted context omitted.

(not op) for reference, 39g of oats contains 28g of carbohydrates. https://www.hsph.harvard.edu/nutritionsource/what-should-you... - The biggest influence on blood cholesterol level is the mix of fats and carbohydrates in your diet—not the amount of cholesterol you eat from food. - Although it remains important to limit the amount of cholesterol you eat, especially if you have diabetes, for most people dietary choles…

What’s up with the conflicting info on carbohydrates? Should I skip the bowl of oatmeal every morning?

Food science is highly politicised because of the massive amounts of lobbying involved. If you have the time and expertise, you should look at the actual paper, correlate it with things like sample size, age of participants, funders biases and then come up with your own conclusions. Also, research on oneself is great, vary something, measure whether it makes a positive difference, if yes, do more of it, if not, try something else. Lots of 'scientific' nutrition advice is outright wrong and harmful.

Re: Post-SSRI sexual dysfunction

#232

Post by notmymainlogin »

Jaruzel wrote: post #22

My personal anecdote: I'm on Venlafaxine which is an SNRI (also cited in the article), and I definitely suffer some of those side-effects. It sucks. At times it makes me want to shy away from sex completely. Other times I think I'm doing OK, only to find out I can't finish, or I finish weakly with no adrenalin rush. So my choices are, come off the pills, and emotionally go down a dark well I may not come out of, or k…

Wow! This was very educational to me. I'm also on venlafaxine, and have been off and on for more than 15 years. About 5 years ago I went on it more consistently, and at a higher dose.

I'm 38 years old. I... uh.... "concluded", based on my observations of myself that "I guess it's true, male sex drive must peak in the early 30s! Ah well, I had a good run, no regrets!"

Now I don't know what to think! Maybe it's the meds? Or age? Or both? Thanks for this! (meant in earnest, not sarcasm)

Re: Post-SSRI sexual dysfunction

#233

Post by notmymainlogin »

cobertos wrote: post #220
heavyset_go wrote: post #208

Earlier quoted context omitted.

There are two medications on the market that have FDA approval for the claim that they have lower incidences of sexual side effects than other similar medications. One is vortioxetine and the other is vilazodone. In addition to acting as SSRIs, they have high affinities for 5HT1A autoreceptors, activation of which disinhibits the release of neurotransmitters. SSRI sexual side effects are hypothesized to be the result…

Vortioxetine (Trintellix) is expensive as fuck, most insurance plans have it under multiple restrictions (step therapy (ST), prior auth (PA), others). They have a manufacturer discount card to take off $100 max but if your prescription benefits don't kick in until after you're deductible you will max out every year pretty quickly. I just paid $900 for a 3 month supply. But... Anecdotally, it does have less sexual sid…

Have you been on venlafaxine before? If so, how would you compare it to escitalopram, not in terms of sexual side effects but in terms of efficacy with anxiety.

Re: Post-SSRI sexual dysfunction

#234

Post by Osiris »

For someone that suffers from premature ejaculation, these medications are extremely helpful. The trick is to get the right dose that improves your sexual endurance but doesn't prevent orgasm.

Re: Post-SSRI sexual dysfunction

#235

Post by notmymainlogin »

gtirloni wrote: post #214
heavyset_go wrote: post #208

Earlier quoted context omitted.

There are two medications on the market that have FDA approval for the claim that they have lower incidences of sexual side effects than other similar medications. One is vortioxetine and the other is vilazodone. In addition to acting as SSRIs, they have high affinities for 5HT1A autoreceptors, activation of which disinhibits the release of neurotransmitters. SSRI sexual side effects are hypothesized to be the result…

Does it mean they don't also inhibit LSD effects like Venlafaxin does?

I can tell you from first hand experience that Venlafaxine does not inhibit the effects of LSD in all people. It might in some, but certainly not in all. I have one data point.

Also, it does limit, if not entirely mask, the effects of some common recreational dopamine reuptake inhibitors.

Re: Post-SSRI sexual dysfunction

#236

Post by notmymainlogin »

n8cpdx wrote: post #113

As someone dating in their 20s, it is getting hard to find people who aren’t having SSRI-related dysfunction. Recently met an older (early 30s guy) and it was seriously cool having a sexual experience that didn’t end with “don’t bother I’m just not going to finish no matter how long we go.” They really seem to be handing out these serious, almost-impossible-to-withdraw medications like candy on Halloween. They don’t…

I really appreciate your comment, and value honestly, but this:

> Recently met an older (early 30s guy) and it was seriously cool having a sexual experience that didn’t end with “don’t bother I’m just not going to finish no matter how long we go.”

Reading that was like reading that your worst nightmare is actually true. nervous laugh

As a guy in their 30s, on multiple occasions I've comforted myself with "self, it doesn't matter to them if we finish, they're probably so appreciative that we're more focused on them than ourselves. you're doing great, self." And your comment is just NOPE and slashes my self esteem to shreds!

And this too!: > by e.g. not smoking so much weed...

CUTS DOWN MY MENTAL SUPPORT FRAMEWORK LIKE A SCYTHE. :) I needed that solid slap across the face, I was in danger of becoming too comfortable with my sexuality, now I have the ammo to fuel my insecurity and shame, and push it back down where it belongs. A million thanks.

Re: Post-SSRI sexual dysfunction

#237

Post by anon-guy »

n8cpdx wrote: post #113

As someone dating in their 20s, it is getting hard to find people who aren’t having SSRI-related dysfunction. Recently met an older (early 30s guy) and it was seriously cool having a sexual experience that didn’t end with “don’t bother I’m just not going to finish no matter how long we go.” They really seem to be handing out these serious, almost-impossible-to-withdraw medications like candy on Halloween. They don’t…

SSRI withdrawals/side effects are the least worst out of medications like Xanax, beta blockers and other anxiety medicine. So… there are drugs with more devastating effects.

This problem isn’t just related to mental disorders. I think you are also undermining how difficult changing human behavior is, especially in relation to mental disorders and addictions. Ideally, SSRI’s are used to make behavioral changes easier.

Re: Post-SSRI sexual dysfunction

#238

Post by anon-guy »

jamal-kumar wrote: post #45

SSRIs need to be obsolesced already. Screw the sexual dysfunction, how about increaased risk of suicidal ideation? How about them taking two entire weeks to work? The thing is the rest of the world doesn't seem to feel the burning desire to get as many people on them as possible and even have alternatives which aren't as limited. Reversible MAOI drugs like moclobemide have been around since the 90s and while they hav…

http://www.nature.com/npp/journal/v20/n3/pdf/1395258a.pdf

You have to take pills more often (3x a day vs 1 a day) and only one potential benefit over SSRI which is less likelihood of sexual dysfunction.

Re: Post-SSRI sexual dysfunction

#239

Post by anon-guy »

wayoutthere wrote: post #137
iammisc wrote: post #125

Earlier quoted context omitted.

I am a straight man, so have no experience with other men obviously, but this is fascinating. How can it be that so many of us are on antidepressants? Something is surely wrong as you've said right? There may also be selection effects as men in their late 30s may not have 'paired up' so to speak due to depression. But still, I'm curious if anyone has stats on how many people are on these drugs.

About 15-20%. But that’s just the antidepressants; sexual dysfunction can also be caused by blood pressure medication, epilepsy meds, etc. Anecdotally I would say regular sexual dysfunction among men over 35 is probably closer to 50%. I don’t know how this compares to past eras though.

Just 200 years ago, that 35 year old man would probably be dead already. Medicine has given us a longer life span and evolution hasn’t caught up.

Re: Post-SSRI sexual dysfunction

#240

Post by anon-guy »

I wish this article referenced the data used in the sentence where it claims certain facts.

Such as the first sentence: “Close to 100% of people who take antidepressants experience some form of sexual side effects.”

Says who?

There are certain studies referenced but when other claims like the first sentence are made, I’d like to see where they got that conclusion.

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