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Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

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Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#231

Post by LinuxBender »

olva22 wrote: post #191
LinuxBender wrote: post #142

Earlier quoted context omitted.

Just anecdotal observation, I have been taking 40,000 IU D3, 800mcg K2, 400mg Magnesium among other things, daily for 3+ years, no issue. I had to work my way up to that. I've been reversing calcium buildup in my vascular system to lower my CaC score. I know of many people doing the same thing, some longer than I have been. We are all doing good. I also stay well hydrated.

Sorry a bit off-topic, but what form of K2 and magnesium do you take? Can you point me to your protocol to reverse calcium buildup?

I can point you to some of the studies on calcium removal. [1] They don't create a well defined protocol, though doctors have formed their own. I take 600mcg K2 MK-7 and 200mcg of K2 MK-4. I alternate between Magnesium-lysinate-glycinate-chelate (bound to L-Lysine and L-Glycine) and Magnesium Citrate. Since I am listing papers I have to point out that I am not a doctor and this is not medical advise. This method has been working slowly for me and faster for others, likely due to epigenetic and environment factors. I take these things with fatty meals to allow D3 binding and absorption.

[1] - https://www.google.com/search?hl=en&source=hp&biw=&bih=&q=si...

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#232

Post by spuz »

MiroF wrote: post #95
barbegal wrote: post #71

Earlier quoted context omitted.

I'm just slightly surprised that the study wasn't made randomized. I can't see any ethical reason why that couldn't have been done but maybe there were logistical reasons. Larger randomized trials are in progress [1][2] but the results won't be published until July. [1] https://clinicaltrials.gov/ct2/show/NCT04344041 [2] https://clinicaltrials.gov/ct2/show/NCT04351490 .

Because it's an observational study? It wasn't an experiment. They couldn't make it randomizes. This is often the first stage before an RCT. Don't see what's confusing about this.

The study authors decided to administer DMB to all patients who arrived for treatment at the hospital after a certain date - I don't see why they could not have decided to administer DMB to 50% of patients and turn the study from an observational study into an RCT.

> As the COVID-19 situation evolved, we decided from 6 April 2020, to start DMB on all COVID-19 patients above 50 years old upon hospitalization and before the onset of the primary outcome event. Patients admitted during this period who did not receive DMB before event onset were served as control. Therapy comprised a single daily oral dose of vitamin D3 1000 IU, magnesium 150mg and vitamin B12 500mcg for up to 14 days

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#233

Post by Nursie »

wegs wrote: post #230
Nursie wrote: post #29

Earlier quoted context omitted.

Many things are almost entirely harmless, but before recommending you do them anyway, you probably want to look at whether there's any point. Turning round in a circle three times before you leave the house is almost entirely harmless, and there's no evidence that doesn't stop you getting coronavirus...

This is a question of decision-making in the face of uncertainty. We have evidence this helps. It's not conclusive evidence. The odds of turning round in a circle three times helping are 0.000000001%. The odds of DMB helping are probably less than 50%, but more than 5% at this point. The cost is minimal. Generally, one does an ROI calculation. To mix units and otherwise have zero rigor: Return: P(treatment helps) * h…

The evidence is weak, they cost money.

AFAICT Vitamin D supplementation may well be snake oil, as low vitamin D levels may be symptomatic of another condition which supplementing won't help.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#234

Post by Vrondi »

pbhjpbhj wrote: post #37
Traubenfuchs wrote: post #19

Earlier quoted context omitted.

You are right and it is no secret: - 40% of US Americans are B12 deficient https://www.livekindly.co/b12-deficiency-genetic-makeup/#:~:... . - 42% are Vitamin D deficient: https://www.cantonmercy.org/healthchat/42-percent-of-america... . - up to 50% are Magnesium deficient: https://www.sciencedaily.com/releases/2018/02/180226122548.h... - 10 - 20% of women are iron deficient: https://www.aafp.org/afp/2007/0301/p671.h…

Presumably it's relatively easy for a lab to run a panel of tests on me and say "you're deficient in X, Y, Z; try eating more A B C; spend 30mins extra a week outside; drink less alcohol". How easy is it too get such tests (in UK), I'm surprised we don't seem to have anything like this as part of our health system. I've had blood pressure and height/weight taken a couple of times (I'm middle aged). But that's about a…

The medical school at the university nearest me offers a range of such tests on a walk-in basis for prices ranging from around $15-40 USD each. Obviously, YMMV, but inquire with any medical schools near you that have research hospitals or training clinics.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#235

Post by eridan2 »

valarauko wrote: post #123
cseleborg wrote: post #99

Earlier quoted context omitted.

I've always wondered about this deficiency thing. How is it defined, and does it make any sense to claim that such a large part of the population is deficient? Shouldn't that be considered "normal" (excluding the truly pathological cases), as opposed to "above-average"?

At least for Vit D and B12, the healthy levels were determined by establishing levels in "healthy" cohorts. Deficiency diseases for both of these vitamins are relatively rare, so it is easier to establish a wider "safe" range, rather than "deficiency" ranges. There's been a great deal of debate on safe Vit D levels, and the consensus (such as it is) is that a serum level of 30 ng/mL is likely optimal. Yet there are m…

there are recommended serum levels for B12: >200pg/mL for Europeans

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#236

Post by caleb-allen »

axegon_ wrote: post #210
caleb-allen wrote: post #169

Earlier quoted context omitted.

I recently started on a 250mg Magnesium Citrate supplement. I began taking it because I have been experiencing weakness in my hands, and after some research reasoned it probably wouldn't hurt to at least try the supplements. I also saw a study that said that 95% of children diagnosed with ADHD are magnesium deficient [0]! Another found a "significant decrease of hyperactivity" in children who were given oral magnesiu…

As far as the magnesium citrate goes, I don't see any reasons to stop taking it either. There have been cases when I've forgotten to take it for a day or two and I can feel the difference in the morning after a heavier workout. As for your hands, given that you are focusing on upper body workouts maybe one up your protein intake, see if that improves things. Unless you are a vegan, Icelandic yogurt(skyr) is a pretty…

That's probably a good idea! I've been looking for a good protein to add in to my diet, I'll need to take a look to see if my grocery store carries this once I can go again (closed due to the protests)

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#237

Post by LorenPechtel »

isoprophlex wrote: post #151
tootie wrote: post #89

Earlier quoted context omitted.

I wouldn't be surprised if quarantine is leading to an historic spike in D deficiency.

I haven't been this tan in years! It's been really easy to go outside for a walk, I hope to keep it up in the coming years...

We have been seeing a lot of that on the hiking trails around here. They're swamped, mask compliance is near zero and they're litterbugs. We are also getting undesirable elements out there--vandalism and things like snatching phones.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#238

Post by LorenPechtel »

jibbit wrote: post #158
cseleborg wrote: post #99

Earlier quoted context omitted.

I've always wondered about this deficiency thing. How is it defined, and does it make any sense to claim that such a large part of the population is deficient? Shouldn't that be considered "normal" (excluding the truly pathological cases), as opposed to "above-average"?

Similarly with drinking 3 litres of water a day, or you're dehydrated. How did our ancestors get 3 litres of water a day? Seems like the first person ever who wasn't dehydrated was born around 1985.

The research was seriously misreported--you don't actually need to drink anything like that much, the number is for total dietary intake in any form. With enough juicy food there's no need to actually drink anything. I'm reminded of one day my wife saying she was thirsty, please cut a slice of watermelon. At first I thought it was an English mistake (it's not her native language) but that's really what she meant.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#239

Post by partyboat1586 »

nradov wrote: post #86
partyboat1586 wrote: post #60

Earlier quoted context omitted.

Dr Rhonda Patrick was the guest if anyone is interested. Worth watching with paper and pen (or digital equivalent).

Show notes are here. https://www.foundmyfitness.com/episodes/jre-1474

Damn, I already took all my own notes! Thanks for this.

Re: Study of the effect of Vitamin D, Magnesium and Vitamin B12 on Covid-19 patients

#240

Post by aaron695 »

arghzzz wrote: post #22
barbegal wrote: post #15

The methodology mentions nothing about randomization so its unclear if there was any selection bias here. If you look a table 2, the control group was on average 6 years older and had more co-morbidities. This suggests that there was some selection bias and that other undocumented factors could have greatly affected this experiment. Doing multi-variate analysis with such a small sample size gives rise to huge uncerta…

However, taking 3 vitamins is almost entirely harmless.

No, if you take the wrong 3 vitamins then your just harmed yourself by not taking the correct 3 or 2 or 5.

Nicotine patches also have been said to help.

Every study like this distracts from other studies, so it needs to be pushing towards correct.

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