Adderall Addiction: The Last All-Nighter • Hacker News Board

Re: Adderall Addiction: The Last All-Nighter

#221

Post by throwaway04583 » Sat, Mar 09, 2013, 6:37 PM UTC

danneu wrote: post #213

throwaway04583 wrote: post #126

Earlier quoted context omitted.

I realize you're probably trolling, but just in case.. The 'high' of adderall is not even remotely similar to cocaine.

Cocaine and amphetamine result in the same flood of the same neurotransmitters. Cocaine has no surprises for anyone that's ever been cracked out on instant release speed. Except maybe making them go "...is this it?" Lots of overlap between the two, especially when comparing pharmacophores. For instance, the peptide transcript called the "cocaine- and amphetamine-regulated transcript (CART)"[1] might be a good example…

I have had substantial experience with both of them, and while the effect is similar, the feeling is not. In my experience, cocaine has a stronger euphoric component than d-amp. Adderall makes me logical and emotionally detached, while cocaine makes me feel like I'm on top of the world.

I think the reason for using the substance could be coloring my opinion of the experience, since I use adderall to get work done, and when I use cocaine (not often, maybe once or twice a year. I did a decent amount of blow when I was doing opiates heavily), it's almost always in a social setting.

I will grant that the pharmacological effects are very similar.

Re: Adderall Addiction: The Last All-Nighter

#222

Post by kragen » Tue, Mar 12, 2013, 7:25 PM UTC

throwaway54-762 wrote: post #220

kragen wrote: post #219

Earlier quoted context omitted.

> I don't even try to use amphetamines for productivity anymore because they don't clear from my system fast enough to avoid interfering with my sleep. Some people have told me that they prefer cocaine to amphetamine specifically for this reason: its metabolic half-life is something like two hours, if I recall. Have you tried using cocaine instead? I'm not sure if the toxic side effects are more or less severe; maybe…

I wouldn't want to try and use cocaine to focus. While I've tried it once, I don't like the typical routes of administration, the lack of quality control, and financially, supporting the drug cartels. The only drug I use regularly is caffeine, also (coffee) =).

Hmm, I think most people who take cocaine just chew coca leaf, which eliminates all three of your concerns. There may not be any people taking cocaine by that route anywhere near you, though.

Re: Adderall Addiction: The Last All-Nighter

#223

Post by throwaway54-762 » Tue, Mar 12, 2013, 10:17 PM UTC

kragen wrote: post #222

throwaway54-762 wrote: post #220

Earlier quoted context omitted.

I wouldn't want to try and use cocaine to focus. While I've tried it once, I don't like the typical routes of administration, the lack of quality control, and financially, supporting the drug cartels. The only drug I use regularly is caffeine, also (coffee) =).

Hmm, I think most people who take cocaine just chew coca leaf, which eliminates all three of your concerns. There may not be any people taking cocaine by that route anywhere near you, though.

Yeah, I live in the PNW of the US, not South America. Coca leaves are basically unavailable.