Cuba is making progress in this space. Good thing the US has been doing everything in its power to destroy the country
https://www.bellyofthebeastcuba.com/us-citizens-in-cuba-for-...
Why has there been so little progress on Alzheimer's disease?
221–230 of 355 posts
Re: Why has there been so little progress on Alzheimer's disease?
#222Re: Why has there been so little progress on Alzheimer's disease?
#223Earlier quoted context omitted.
> Autopsies of brains of Alzheimer's patients were rife with amyloid Do you want think carefully about how this can possibly suggest this is a causal link? > People with mutations that caused amyloid got Alzheimer's earlier than others. People with mutations in those genes got a particular type of inherited alzheimers early, this says nothing about the cause of general Alzheimers.
This comment is so needlessly aggressive and argumentative. I hate this about HN
It’s the way one talks to an LLM which has made a mistake.
Re: Why has there been so little progress on Alzheimer's disease?
#224They had a biological model. They had multiple drugs that were showed activity against that model, and effectiveness in humans. Problem was, the model was wrong. Pharma’s burned billions chasing this as it’s possibly the biggest market imaginable. Whether it was fraudulent or just incorrect is a different question. We don’t know all of the details of human biology. We don’t even know what all we don’t know. Most gues…
> Problem was, the model was wrong. I thought despite the fraud, it's still the best model we have[1]? The fact there was fraud doesn't mean the model is immediately incorrect. At best, it means its foundations are shakier than we thought, but it's not a slam dunk repudiation. [1] https://www.astralcodexten.com/p/in-defense-of-the-amyloid-h...
the model is wrong, but the amyloid is still sitting there, staring at you, asking you what are you going to do about it?
Re: Why has there been so little progress on Alzheimer's disease?
#225Earlier quoted context omitted.
> It's much like climate science today: any dissent at all, even just questioning the predictions of catastrophe, immediately brands you as a heretic. I think this is not a great example, as there’s a huge group of people that, in fact, does not agree with the consensus and would happily fund research that (tries to) prove otherwise. I fully agree with your point, though, just not the example.
Over the past decades the group that are not happy with the AGW consensus in the hard earth sciences crowd have principally funded FUD via think tanks, ala the pro-tobacco lobby back in the day, rather than research. The few examples of research driven from the skeptic PoV (eg: urban heat skewing, etc) have landed on the side of the AGW consensus.
And when they funded research, it confirmed the known science.
https://www.scientificamerican.com/article/exxon-knew-about-...
If anything the current consensus on the scientific front lines is that the alarmism is understated, and the real orthodoxy is astroturfed denial of the facts.
The global fossil industry is worth around $11 trillion a year. It supports some of the worst regimes in the world.
Of course they're going to try to FUD away the science, with the usual copy-paste narratives about how it's really scientists and academics who are corrupt.
It's all about money, power, and entitlement. Not about truth or responsibility.
But no amount of PR nonsense, astroturfing, and false accusation is going to make the slightest difference to climate reality.
Re: Why has there been so little progress on Alzheimer's disease?
#226Cuba is making progress in this space. Good thing the US has been doing everything in its power to destroy the country https://www.bellyofthebeastcuba.com/us-citizens-in-cuba-for-...
Surprised to see anyone mentioning this here, NeuralCIM has been talked about for years behind the iron curtain. They also developed their own COVID vaccine and send hundreds of thousands of doctors to countries in the global south but even rich nations when they need help dealing with natural disasters. The US is viciously targeting them doing incredible harm nobody ever talks about.
https://venezuelanalysis.com/news/us-hardens-sanctions-targe...
Re: Why has there been so little progress on Alzheimer's disease?
#227Well apparently you can be a president while suffering it.
Re: Why has there been so little progress on Alzheimer's disease?
#228Re: Why has there been so little progress on Alzheimer's disease?
#229"Do not attribute to malice what can be attributed to incompetence" and all of that, but... Alzheimer's (like a gazillion other diseases) is a product of senescence, and senescence is a subject that faces strong ideological headwinds. That leaves the medical system in a situation where they want to treat the symptoms (the diseases) instead of the root cause, and treating the set of symptoms that we call Alzheimer's i…
As a society we are so used to seeing our grandparents and parents die that thinking otherwise is near impossible. I wish we saw ageing as a disease it is, instead of a "natural therefore good" thing.
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Re: Why has there been so little progress on Alzheimer's disease?
#230I'll say that I know nothing about this, but just commenting on the economics of it all: Cancer and HIV have been at the forefront of disease research, in terms of public interest and financial investment, and cancer is more like an umbrella of similar diseases than a single disorder. HIV is manageable these days, and cancer research is slowly seeing leaps in progress. Alzheimer is very important, and affects a very…
The potential profits from an Alzheimer’s treatment are extremely high, I doubt it’s being overlooked. > and it's hard to think our older loved ones might be affected A large proportion of people don’t need to think about it because they have witnessed the horrific effects on loved ones first hand.
but not as much as cancer or hiv