221–230 of 276 posts
I can't think of anything in the world I would enjoy doing less than completing "a simple auditory–visual matching task" while in an MRI scanner on shrooms.
Haha I wouldn't. People have made such a big deal out of this drug requiring set and setting but I've swum in the ocean, played soccer, watched movies and TV, played board games and all with great fun. Indoors and outdoors. It's fantastic.
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Psilocybin and LSD are both psychedelics and 5-HT2A agonists. Even though the study uses psilocybin, the findings should apply to LSD too.
Not really. Two ligands of the same receptor can have very different effects. There are 5ht2a agonists who don’t even cause perceptual effects. Besides, LSD has activities at several other receptors as well, which contributes to its effect. Extrapolation of biological effect based on the receptor affinity of a ligand is a pretty crude hypotheses.
> To determine whether this reflects a common effect of psilocybin that generalizes across datasets and psychedelics, we calculated dimension 1 scores for extant datasets from participants receiving intravenous (i.v.) psilocybin55 and lysergic acid diethylamide (LSD)56. Psychedelic treatment increased dimension 1 in nearly every participant in the psilocybin and LSD datasets (Fig. 2c), suggesting that this is a common effect across psychedelic drugs and individuals.
incredibly powerful drug. we should be training a legion of mystics using psilocybin instead of criminalizing it and obfuscating the implications of its use
> training a legion of mystics Oh yeah! But what does that mean?
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Feeling "it is just a feeling" is also just a feeling.
Not really, have you ever tried to articulate one of your "big epiphanies" while on hallucinogens? In my experience (and experience of people I'm with) it inevitably comes out as babble. Maybe that's just because the insight is too profound to capture with language but somehow I doubt it
I have never taken hallucinogens, but I suspect I have undiagnosed narcolepsy, which causes me to occasionally experience normally unconscious sleep states in more conscious way: lucid dreams, sleep paralysis, and (the weirdest of all) being conscious of falling asleep.
My experience with the latter sounds a lot like what some people are reporting in this thread. When I am in this state where I am falling asleep, but still fully conscious, I start thinking complete nonsense — sort of like wooliness is profoundly connected the concept of leftness or like ovals are one of the primary colors (but honestly much less coherent than that).
My suspicion is that it's caused by various neurons firing stochastically as part of the process of falling asleep, and it gives me the sensation that these unrelated concepts are connected to each other. I think we are supposed to be unconscious when this happens so we don't inadvertently take meaning from what is essentially random noise.
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> I don't believe there are any known pharmacological effects from psilocybin or psilocin that would cause any of that What are your qualifications to make a claim like that? There hasn't been much clinical research in humans using psilocybin until very recently [1], and they certainly do not cover the range of different species of mushrooms that contain the alkaloids [2]. 1. https://www.ncbi.nlm.nih.gov/pmc/articles…
My qualifications for saying "I don't believe there are any known effects that match that" is... reading quite a lot of clinical research on their usage, and not having seen anything that would match those effects. You'll notice I qualified that statement in two ways - both that it is limited to my personal understanding and that of 'known' effects. I'm not really sure what you're arguing - neither of these links ind…
> neither of these links indicate otherwise
The articles I provided were to back my own statements that I made, not to refute yours, and I am not sure how that wasn't clear.
> I'm not really sure what you're arguing
I am saying that there really isn't a large enough body of scientific evidence yet to conclude definitively that there are no possible mechanisms that could cause this effect, as you stated. Humans aren't uniform systems.
> Are you familiar with the null hypothesis?
Yeah.
> it's the first I've ever encountered that sort of story about persistent headaches for multiple weeks following their usage.
HPPD comes to mind, serotonin syndrome, all sorts of possibilities that do not necessitate it being caused by another substance.
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> Feeling "I solved the world, everybody listen to me" is... not. Does this apply to the preceding paragraph in your comment? How about to science, and various other The Way's currently popular bordering on mandatory (if you want to be respected at least) in this era, culture, geographical region?
Science is all about removing feelings, accepting that it isn’t possible to not feel and channel that into constantly doubting. Feeling doubtful is fundamentally different than feeling enlightened.
Lots of people have a lot of negative stuff to say, but my take is: if you do psychedelics, you need to do the work and you need a firm ground before that. We have research that it might help with PTSD, depression, etc. but it's not like you just take it and you're done. It's a powerful substance and with power comes responsibility. I like to think of it more as an enhancer as to what's inside your head anyways. If t…
Psychedelics weaken your emotional associations. Which can be helpful and/or unhelpful. It's not a matter of more work. Whatever feeling you had about this chair has changed. It use to represent a memory or a feeling from childhood. That's changed or is gone for better or worse. That's how to perceive how it works. If you are 'fucked' because you can't move on it will help. If you feel a lack of connections to things…
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The amount of antivax shit that floats around in a supposedly well informed community such as this is nauseating. Makes me lose my faith in humanity a bit every time I read it.
It's just orange reddit
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The amount of antivax shit that floats around in a supposedly well informed community such as this is nauseating. Makes me lose my faith in humanity a bit every time I read it.