> Vertex set the price of Casgevy at $2.2 million > Patients must spend weeks, even months, in the hospital before and after the therapy is administered. Yoiks. So how many actual people are going to be able to get this treatment?
FDA approves a CRISPR-based medicine for treatment of sickle cell disease
221–228 of 228 posts
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#222Ohalo (the company Dave Friedberg is now CEO of) recently got approval for a potato edited by CRISPR: > Ohalo had two RSRs under consideration this year for its potato, one which focuses on higher concentrations of beta carotene – enhancing the overall health and nutrition value of the potato – and another which results in reduced glucose and fructose content in the potato, which, according to Ohalo, will reduce the…
>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame instead of sugars!
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#223Earlier quoted context omitted.
Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.
Decades of research have found rare, but still very mildly negative health results from aspartame, and an overwhelming flood of direct evidence for strong negative health effects from sugar. Back up what you are saying with some studies. Because what you are claiming is going against a LOT of modern medical knowledge.
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#224Earlier quoted context omitted.
Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.
Extraordinary claims require extraordinary evidence. Can you back any of this up, or provide a reason I should believe what you’re saying? Because it directly contradicts decades of research on what is perhaps the most scrutinised and studied dietary supplement in the world. Aspartame is safe, and very well tolerated. You’re spreading misinformation.
Here, have a read. I have more if you would like them.
https://journals.plos.org/plosmedicine/article?id=10.1371/jo...
https://www.sciencedaily.com/releases/2022/03/220324143800.h...
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0...
http://www.mpwhi.com/soffritti_2010_20896_fta.pdf
https://ehjournal.biomedcentral.com/articles/10.1186/s12940-...
https://annalsofglobalhealth.org/articles/10.5334/aogh.4163
http://ajcn.nutrition.org/content/96/6/1419.long
https://www.ncbi.nlm.nih.gov/pubmed/24436139
https://www.pnas.org/doi/10.1073/pnas.2213120119
https://news.fsu.edu/news/university-news/2022/12/08/fsu-res...
https://www.nature.com/articles/s41598-023-41213-2
https://www.ncbi.nlm.nih.gov/pubmed/8939194
https://www.youtube.com/watch?v=yCoBuTr0Or0
http://www.cmaj.ca/content/189/28/E929
https://www.statnews.com/2017/07/17/artificial-sweeteners-we...
https://blogs.wsj.com/experts/2017/09/14/why-one-cardiologis...
https://www.philly.com/philly/health/this-cardiologist-wants...
https://www.ncbi.nlm.nih.gov/pubmed/27129676
http://stroke.ahajournals.org/content/early/2017/04/20/STROK...
https://www.bumc.bu.edu/busm/2017/04/20/daily-consumption-of...
https://www.washingtonpost.com/news/morning-mix/wp/2017/04/2...
https://www.ncbi.nlm.nih.gov/pubmed/24787915
https://www.ncbi.nlm.nih.gov/pubmed/24787917
https://www.ncbi.nlm.nih.gov/pubmed/1579221
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1474447/pdf/env...
https://www.ncbi.nlm.nih.gov/pubmed/28198207
https://www.ncbi.nlm.nih.gov/pubmed/28049023
https://www.ncbi.nlm.nih.gov/pubmed/17684524
http://www.sciencedirect.com/science/article/pii/S1043661805...
https://diabetesjournals.org/care/article/doi/10.2337/dc23-0...
https://www.ncbi.nlm.nih.gov/pubmed/27997218
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#225Earlier quoted context omitted.
>and another which results in reduced glucose and fructose content in the potato, That's pretty amazing. Imagine if we can change apples to produce Aspartame instead of sugars!
Unless you are diabetic, aspartame is much worse for you than sugar. It causes metabolic issues, such as reduced metabolism (leading to more weight gain than a subjectively equivalent amount of sugar), migraines in some people, interacts with drugs, is bad for your digestive tract, and probably has other side effects. Even if you are diabetic, you can already eat apples. They have a low glycemic index.
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#226Earlier quoted context omitted.
Extraordinary claims require extraordinary evidence. Can you back any of this up, or provide a reason I should believe what you’re saying? Because it directly contradicts decades of research on what is perhaps the most scrutinised and studied dietary supplement in the world. Aspartame is safe, and very well tolerated. You’re spreading misinformation.
You are the one spreading misinformation. Aspartame is horrible for you. Here, have a read. I have more if you would like them. https://journals.plos.org/plosmedicine/article?id=10.1371/jo... https://www.sciencedaily.com/releases/2022/03/220324143800.h... https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1392232/ http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1964906/pdf/ehp0... http://www.mpwhi.com/soffritti_2010_20896_fta.…
For the author, try reading some of these papers. Also don't bother linking to press releases or newspaper articles, you're just wasting other people's time. You probably want to skip the animal studies too. Go for no more than three links, preferably meta-studies -- at least if your intention is to be taken for something other than a crank.
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#227Earlier quoted context omitted.
1. Soy, brown rice, pea, corn, and potato all hit their EAA/total protein cut-off. 2. I don't see how amino acid % of total protein is a useful way to gauge a food's protein especially in this context. Wouldn't you want to look at protein per calorie or EAA per calorie? For example the paper's chart might make you think that you should eat potatoes and corn if you want to maximize plant-based protein, but that's not…
Don't compare whole potato, it should be to potato protein extract.
But your comment on the EAA/totalProtein ratio (when potatoes are very low in protein) possibly being responsible for why potatoes taste good made me chime in for clarification.
Re: FDA approves a CRISPR-based medicine for treatment of sickle cell disease
#228Earlier quoted context omitted.
1. Soy, brown rice, pea, corn, and potato all hit their EAA/total protein cut-off. 2. I don't see how amino acid % of total protein is a useful way to gauge a food's protein especially in this context. Wouldn't you want to look at protein per calorie or EAA per calorie? For example the paper's chart might make you think that you should eat potatoes and corn if you want to maximize plant-based protein, but that's not…
> Wouldn't you want to look at protein per calorie or EAA per calorie? PDCAAS is a reasonable standard to use, pro-rated against total calories. https://en.m.wikipedia.org/wiki/Protein_Digestibility_Correc...
A food with 1000x the EAAs per calorie of every other food, but 0 of one EAA would score below the other foods even though you could get the day's worth of EAA on 1/1000 the calories + one serving of an additional food that can give you the missing EAA (i.e. eat more than one food every day).