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GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

fiercebiotech.com

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Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#221

Post by crb002 »

breck wrote: post #43
dayvid wrote: post #24

I asked 23andMe if there was any way to delete my genetic data from their site after the Equifax hack news. From their response: "23andMe and our third party genotyping laboratory will retain Genetic Information, date of birth, and sex as required for compliance with applicable legal obligations, including the U.S. Federal Clinical Laboratory Improvement Amendments of 1988 (CLIA), California Business and Professional…

I believe there are services that will do whole genome seq for you for under $10k(and I assume won’t keep your data). You could then use Promethease for analysis. I’m unaware of any way you could do self-DNA testing at home unless you wanted to spend $100k+ on equipment, reagents, etc. The Nanopore might be relevant but I haven’t looked into it much.

You could do it at Stanford or Iowa State for like $3k ? You would still have to prep the samples.

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#222

Post by cncrnd »

berberous wrote: post #220
cncrnd wrote: post #218

Earlier quoted context omitted.

What'd you use to analyze your genome, promethease? I think that increased risks of x,y,z would be good to be aware of.

Yes, promethease. Have you done 23andme? It also gives you increased risks, but usually none that are helpful. For example, if it says that you have some Snaps that increase your risks of prostate cancer from 1 in 100 to 2in 100, what do you do with that? 2 in 100 is still so low (even though double baseline population risk), that it's not going to effect my decisions. That's also assuming it's accurate -- other SNPs…

I haven't done it because of privacy concerns, but I am considering WGS through a lab then promethease instead.

I don't think understanding risk would affect my decisions much either, but I'd probably get familiar with the symptoms of things I have a higher chance of to be able to recognize issues earlier. If there are screenings available, maybe I'd start doing them a little earlier or more frequently than prescribed.

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#223

Post by jghn »

jklehm wrote: post #76
breck wrote: post #43

Earlier quoted context omitted.

I believe there are services that will do whole genome seq for you for under $10k(and I assume won’t keep your data). You could then use Promethease for analysis. I’m unaware of any way you could do self-DNA testing at home unless you wanted to spend $100k+ on equipment, reagents, etc. The Nanopore might be relevant but I haven’t looked into it much.

$1000 for the Minion and 2 flow cells. $900 per flow cell after that[0]. For 30x coverage (standard) takes about 15 flow cells[1]. So looking at $12700 to DIY. [0] https://store.nanoporetech.com/flowcells.html [1] https://nanoporetech.com/about-us/news/human-genome-minion

It’s also extremely easy to introduce human error into this process unless you’ve had a lot of practice.

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#224

Post by jghn »

antpls wrote: post #87
jklehm wrote: post #76

Earlier quoted context omitted.

$1000 for the Minion and 2 flow cells. $900 per flow cell after that[0]. For 30x coverage (standard) takes about 15 flow cells[1]. So looking at $12700 to DIY. [0] https://store.nanoporetech.com/flowcells.html [1] https://nanoporetech.com/about-us/news/human-genome-minion

I asked myself the same question some weeks ago, and I did a bit of basic research. I didn't keep the sources, but I found there are 2 types of sequencing : "draft" and "full". From what I found, prices are quickly dropping over the past years, and the "draft" sequencing is becoming more complete. Most likely, 23andMe does a "draft" sequencing. Also I also read the value of $1000 for a draft sequencing. I wonder, giv…

You’ll see 3 things in general:

Genotyping: this is what 23andMe does. Here they’re looking at a few million locations on your genome to see what specific letter you have. These are the locations which are most typically different in humans

Whole Exome Sequenckng (WES): full sequencing of your Exome. this is an oversimplification but the Exome has historically been viewed as where the “useful” DNA

Whole Genome Sequencing (WGS): what the name implies. Can be quite useful in cancer and rare disease research, and were increasingly realizing how much of an oversimplification my explanation of WES is

Almost all commercial “sequencing” that you see advertised is genotyping. And in the real sequencing world WES dominates WGS. In both cases it is due to cost. There are also a ton of options on all of these, such as how many SNPs are on the SNP chip in the genotyping case, or depth of coverage for WES/WGS

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#225

Post by ryanisnan »

toomuchtodo wrote: post #91
ryanisnan wrote: post #47

Earlier quoted context omitted.

Oh come on, don't straw man the actual issues. Nobody is worried about GSK getting rich, but are worried about actual issues like insurance discrimination, loss of privacy, loss of control, etc. I think few people would argue against the benefits of genetic testing, but just because it's a great thing doesn't mean that being complacent around adjacent shady business transactions is the right approach. You can be for…

If I cared about privacy I wouldn’t have had 23andme and the Personal Genome Project do my genotyping. While it may affect me negatively in the future, the net positive (in aggregate with all participants) will exceed that negative value. I’m dead in the long run regardless, and would rather find every way I can be impactful with the time I have left, even in these small ways.

The two things should not be mutually exclusive (privacy and technological advancement). Why do you lay over and just accept that it has to be that way?

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#226

Post by toomuchtodo »

ryanisnan wrote: post #225
toomuchtodo wrote: post #91

Earlier quoted context omitted.

If I cared about privacy I wouldn’t have had 23andme and the Personal Genome Project do my genotyping. While it may affect me negatively in the future, the net positive (in aggregate with all participants) will exceed that negative value. I’m dead in the long run regardless, and would rather find every way I can be impactful with the time I have left, even in these small ways.

The two things should not be mutually exclusive (privacy and technological advancement). Why do you lay over and just accept that it has to be that way?

Because I don’t feel my genome data needs to be private, or that there is value in keeping it private.

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#227

Post by mcculley »

jnurmine wrote: post #214
mcculley wrote: post #187

Earlier quoted context omitted.

How long do you think you will be able to keep your genome private?

Given that it is immaterial property which belongs to me, I should be able to hold on to it as long as I want?

How do you avoid leaving physical copies of it when you go out in public? Do you think there will not be technology to easily collect it?

Re: GlaxoSmithKline makes $300M investment in 23andMe, forms 50-50 R&D pact

#228

Post by citochrome »

According to the National Institute of Health, Many drugs that are currently available are “one size fits all,” but they don't work the same way for everyone. It can be difficult to predict who will benefit from a medication, who will not respond at all, and who will experience negative side effects (called adverse drug reactions). Adverse drug reactions are a significant cause of hospitalizations and deaths in the United States. With the knowledge gained from the Human Genome Project, researchers are learning how inherited differences in genes affect the body’s response to medications. These genetic differences will be used to predict whether a medication will be effective for a particular person and to help prevent adverse drug reactions.
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